Pharmacophore Mapping Combined with dbCICA Reveal New Structural Features for the Development of Novel Ligands Targeting α4β2 and α7 Nicotinic Acetylcholine Receptors

The neuronal nicotinic acetylcholine receptors (nAChRs) belong to the ligand-gated ion channel (GLIC) group, presenting a crucial role in several biological processes and neuronal disorders. The α4β2 and α7 nAChRs are the most abundant in the central nervous system (CNS), being involved in challengi...

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Detalles Bibliográficos
Autores principales: Batista, Victor S., Gonçalves, Adriano Marques, Nascimento-Júnior, Nailton M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735964/
https://www.ncbi.nlm.nih.gov/pubmed/36500328
http://dx.doi.org/10.3390/molecules27238236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735964/
https://www.ncbi.nlm.nih.gov/pubmed/36500328
http://dx.doi.org/10.3390/molecules27238236

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