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A Review on Autophagy in Orofacial Neuropathic Pain
Orofacial neuropathic pain indicates pain caused by a lesion or diseases of the somatosensory nervous system. It is challenging for the clinician to diagnose and manage orofacial neuropathic pain conditions due to the considerable variability between individual clinical presentations and a lack of u...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735968/ https://www.ncbi.nlm.nih.gov/pubmed/36497100 http://dx.doi.org/10.3390/cells11233842 |
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author | Shrivastava, Mayank Ye, Liang |
author_facet | Shrivastava, Mayank Ye, Liang |
author_sort | Shrivastava, Mayank |
collection | PubMed |
description | Orofacial neuropathic pain indicates pain caused by a lesion or diseases of the somatosensory nervous system. It is challenging for the clinician to diagnose and manage orofacial neuropathic pain conditions due to the considerable variability between individual clinical presentations and a lack of understanding of the mechanisms underlying the etiology and pathogenesis. In the last few decades, researchers have developed diagnostic criteria, questionnaires, and clinical assessment methods for the diagnosis of orofacial neuropathic pain. Recently, researchers have observed the role of autophagy in neuronal dysfunction as well as in the modulation of neuropathic pain. On this basis, in the present review, we highlight the characteristics, classification, and clinical assessment of orofacial neuropathic pain. Additionally, we introduce autophagy and its potential role in the modulation of orofacial neuropathic pain, along with a brief overview of the pathogenesis, which in future may reveal new possible targets for treating this condition. |
format | Online Article Text |
id | pubmed-9735968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97359682022-12-11 A Review on Autophagy in Orofacial Neuropathic Pain Shrivastava, Mayank Ye, Liang Cells Review Orofacial neuropathic pain indicates pain caused by a lesion or diseases of the somatosensory nervous system. It is challenging for the clinician to diagnose and manage orofacial neuropathic pain conditions due to the considerable variability between individual clinical presentations and a lack of understanding of the mechanisms underlying the etiology and pathogenesis. In the last few decades, researchers have developed diagnostic criteria, questionnaires, and clinical assessment methods for the diagnosis of orofacial neuropathic pain. Recently, researchers have observed the role of autophagy in neuronal dysfunction as well as in the modulation of neuropathic pain. On this basis, in the present review, we highlight the characteristics, classification, and clinical assessment of orofacial neuropathic pain. Additionally, we introduce autophagy and its potential role in the modulation of orofacial neuropathic pain, along with a brief overview of the pathogenesis, which in future may reveal new possible targets for treating this condition. MDPI 2022-11-30 /pmc/articles/PMC9735968/ /pubmed/36497100 http://dx.doi.org/10.3390/cells11233842 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Shrivastava, Mayank Ye, Liang A Review on Autophagy in Orofacial Neuropathic Pain |
title | A Review on Autophagy in Orofacial Neuropathic Pain |
title_full | A Review on Autophagy in Orofacial Neuropathic Pain |
title_fullStr | A Review on Autophagy in Orofacial Neuropathic Pain |
title_full_unstemmed | A Review on Autophagy in Orofacial Neuropathic Pain |
title_short | A Review on Autophagy in Orofacial Neuropathic Pain |
title_sort | review on autophagy in orofacial neuropathic pain |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735968/ https://www.ncbi.nlm.nih.gov/pubmed/36497100 http://dx.doi.org/10.3390/cells11233842 |
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