Cargando…

A Review on Autophagy in Orofacial Neuropathic Pain

Orofacial neuropathic pain indicates pain caused by a lesion or diseases of the somatosensory nervous system. It is challenging for the clinician to diagnose and manage orofacial neuropathic pain conditions due to the considerable variability between individual clinical presentations and a lack of u...

Descripción completa

Detalles Bibliográficos
Autores principales: Shrivastava, Mayank, Ye, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735968/
https://www.ncbi.nlm.nih.gov/pubmed/36497100
http://dx.doi.org/10.3390/cells11233842
_version_ 1784846904760205312
author Shrivastava, Mayank
Ye, Liang
author_facet Shrivastava, Mayank
Ye, Liang
author_sort Shrivastava, Mayank
collection PubMed
description Orofacial neuropathic pain indicates pain caused by a lesion or diseases of the somatosensory nervous system. It is challenging for the clinician to diagnose and manage orofacial neuropathic pain conditions due to the considerable variability between individual clinical presentations and a lack of understanding of the mechanisms underlying the etiology and pathogenesis. In the last few decades, researchers have developed diagnostic criteria, questionnaires, and clinical assessment methods for the diagnosis of orofacial neuropathic pain. Recently, researchers have observed the role of autophagy in neuronal dysfunction as well as in the modulation of neuropathic pain. On this basis, in the present review, we highlight the characteristics, classification, and clinical assessment of orofacial neuropathic pain. Additionally, we introduce autophagy and its potential role in the modulation of orofacial neuropathic pain, along with a brief overview of the pathogenesis, which in future may reveal new possible targets for treating this condition.
format Online
Article
Text
id pubmed-9735968
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97359682022-12-11 A Review on Autophagy in Orofacial Neuropathic Pain Shrivastava, Mayank Ye, Liang Cells Review Orofacial neuropathic pain indicates pain caused by a lesion or diseases of the somatosensory nervous system. It is challenging for the clinician to diagnose and manage orofacial neuropathic pain conditions due to the considerable variability between individual clinical presentations and a lack of understanding of the mechanisms underlying the etiology and pathogenesis. In the last few decades, researchers have developed diagnostic criteria, questionnaires, and clinical assessment methods for the diagnosis of orofacial neuropathic pain. Recently, researchers have observed the role of autophagy in neuronal dysfunction as well as in the modulation of neuropathic pain. On this basis, in the present review, we highlight the characteristics, classification, and clinical assessment of orofacial neuropathic pain. Additionally, we introduce autophagy and its potential role in the modulation of orofacial neuropathic pain, along with a brief overview of the pathogenesis, which in future may reveal new possible targets for treating this condition. MDPI 2022-11-30 /pmc/articles/PMC9735968/ /pubmed/36497100 http://dx.doi.org/10.3390/cells11233842 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shrivastava, Mayank
Ye, Liang
A Review on Autophagy in Orofacial Neuropathic Pain
title A Review on Autophagy in Orofacial Neuropathic Pain
title_full A Review on Autophagy in Orofacial Neuropathic Pain
title_fullStr A Review on Autophagy in Orofacial Neuropathic Pain
title_full_unstemmed A Review on Autophagy in Orofacial Neuropathic Pain
title_short A Review on Autophagy in Orofacial Neuropathic Pain
title_sort review on autophagy in orofacial neuropathic pain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735968/
https://www.ncbi.nlm.nih.gov/pubmed/36497100
http://dx.doi.org/10.3390/cells11233842
work_keys_str_mv AT shrivastavamayank areviewonautophagyinorofacialneuropathicpain
AT yeliang areviewonautophagyinorofacialneuropathicpain
AT shrivastavamayank reviewonautophagyinorofacialneuropathicpain
AT yeliang reviewonautophagyinorofacialneuropathicpain