Structural Basis of Cysteine Ligase MshC Inhibition by Cysteinyl-Sulfonamides

Mycothiol (MSH), the major cellular thiol in Mycobacterium tuberculosis (Mtb), plays an essential role in the resistance of Mtb to various antibiotics and oxidative stresses. MshC catalyzes the ATP-dependent ligation of 1-O-(2-amino-2-deoxy-α-d-glucopyranosyl)-d-myo-inositol (GlcN-Ins) with l-cystei...

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Detalles Bibliográficos
Autores principales: Pang, Luping, Lenders, Stijn, Osipov, Evgenii M., Weeks, Stephen D., Rozenski, Jef, Piller, Tatiana, Cappoen, Davie, Strelkov, Sergei V., Van Aerschot, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736012/
https://www.ncbi.nlm.nih.gov/pubmed/36499418
http://dx.doi.org/10.3390/ijms232315095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736012/
https://www.ncbi.nlm.nih.gov/pubmed/36499418
http://dx.doi.org/10.3390/ijms232315095

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