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Targeting Mitochondrial Dynamics Proteins for the Development of Therapies for Cardiovascular Diseases

Cardiovascular diseases are one of the leading causes of death worldwide. The identification of new pathogenetic targets contributes to more efficient development of new types of drugs for the treatment of cardiovascular diseases. This review highlights the problem of mitochondrial dynamics disorder...

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Autores principales: Blagov, Alexander V., Kozlov, Sergey, Blokhina, Tatiana, Sukhorukov, Vasily N., Orekhov, Aleksander N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736032/
https://www.ncbi.nlm.nih.gov/pubmed/36499064
http://dx.doi.org/10.3390/ijms232314741
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author Blagov, Alexander V.
Kozlov, Sergey
Blokhina, Tatiana
Sukhorukov, Vasily N.
Orekhov, Aleksander N.
author_facet Blagov, Alexander V.
Kozlov, Sergey
Blokhina, Tatiana
Sukhorukov, Vasily N.
Orekhov, Aleksander N.
author_sort Blagov, Alexander V.
collection PubMed
description Cardiovascular diseases are one of the leading causes of death worldwide. The identification of new pathogenetic targets contributes to more efficient development of new types of drugs for the treatment of cardiovascular diseases. This review highlights the problem of mitochondrial dynamics disorders, in the context of cardiovascular diseases. A change in the normal function of mitochondrial dynamics proteins is one of the reasons for the development of the pathological state of cardiomyocytes. Based on this, therapeutic targeting of these proteins may be a promising strategy in the development of cardiac drugs. Here we will consider changes for each process of mitochondrial dynamics in cardiovascular diseases: fission and fusion of mitochondria, mitophagy, mitochondrial transport and biogenesis, and also analyze the prospects of the considered protein targets based on existing drug developments.
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spelling pubmed-97360322022-12-11 Targeting Mitochondrial Dynamics Proteins for the Development of Therapies for Cardiovascular Diseases Blagov, Alexander V. Kozlov, Sergey Blokhina, Tatiana Sukhorukov, Vasily N. Orekhov, Aleksander N. Int J Mol Sci Review Cardiovascular diseases are one of the leading causes of death worldwide. The identification of new pathogenetic targets contributes to more efficient development of new types of drugs for the treatment of cardiovascular diseases. This review highlights the problem of mitochondrial dynamics disorders, in the context of cardiovascular diseases. A change in the normal function of mitochondrial dynamics proteins is one of the reasons for the development of the pathological state of cardiomyocytes. Based on this, therapeutic targeting of these proteins may be a promising strategy in the development of cardiac drugs. Here we will consider changes for each process of mitochondrial dynamics in cardiovascular diseases: fission and fusion of mitochondria, mitophagy, mitochondrial transport and biogenesis, and also analyze the prospects of the considered protein targets based on existing drug developments. MDPI 2022-11-25 /pmc/articles/PMC9736032/ /pubmed/36499064 http://dx.doi.org/10.3390/ijms232314741 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Blagov, Alexander V.
Kozlov, Sergey
Blokhina, Tatiana
Sukhorukov, Vasily N.
Orekhov, Aleksander N.
Targeting Mitochondrial Dynamics Proteins for the Development of Therapies for Cardiovascular Diseases
title Targeting Mitochondrial Dynamics Proteins for the Development of Therapies for Cardiovascular Diseases
title_full Targeting Mitochondrial Dynamics Proteins for the Development of Therapies for Cardiovascular Diseases
title_fullStr Targeting Mitochondrial Dynamics Proteins for the Development of Therapies for Cardiovascular Diseases
title_full_unstemmed Targeting Mitochondrial Dynamics Proteins for the Development of Therapies for Cardiovascular Diseases
title_short Targeting Mitochondrial Dynamics Proteins for the Development of Therapies for Cardiovascular Diseases
title_sort targeting mitochondrial dynamics proteins for the development of therapies for cardiovascular diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736032/
https://www.ncbi.nlm.nih.gov/pubmed/36499064
http://dx.doi.org/10.3390/ijms232314741
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