Cargando…

Acarbose Protects Glucolipotoxicity-Induced Diabetic Nephropathy by Inhibiting Ras Expression in High-Fat Diet-Fed db/db Mice

Diabetic nephropathy (DN) exacerbates renal tissue damage and is a major cause of end-stage renal disease. Reactive oxygen species play a vital role in hyperglycemia-induced renal injury. This study examined whether the oral hypoglycemic drug acarbose (Ab) could attenuate the progression of DN in ty...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hung, Tung-Wei, Yu, Meng-Hsun, Yang, Tsung-Yuan, Yang, Mon-Yuan, Chen, Jia-Yu, Chan, Kuei-Chuan, Wang, Chau-Jong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736061/ https://www.ncbi.nlm.nih.gov/pubmed/36499639 http://dx.doi.org/10.3390/ijms232315312

Ejemplares similares

Mulberry Leaf and Neochlorogenic Acid Alleviates Glucolipotoxicity-Induced Oxidative Stress and Inhibits Proliferation/Migration via Downregulating Ras and FAK Signaling Pathway in Vascular Smooth Muscle Cell
por: Yang, Tsung-Yuan, et al.
Publicado: (2022)

Acarbose Accelerates Wound Healing via Akt/eNOS Signaling in db/db Mice
por: Han, Xue, et al.
Publicado: (2017)

Acarbose ameliorates spontaneous type-2 diabetes in db/db mice by inhibiting PDX-1 methylation
por: Zhou, Diyi, et al.
Publicado: (2021)

Gallic Acid Improves Diabetic Steatosis by Downregulating MicroRNA-34a-5p through Targeting NFE2L2 Expression in High-Fat Diet-Fed db/db Mice
por: Lee, Ang-Tse, et al.
Publicado: (2021)

Acarbose attenuates migration/proliferation via targeting microRNA-143 in vascular smooth muscle cells under diabetic conditions
por: Chuang, Wei-Yuan, et al.
Publicado: (2020)

Mycophenolate Mofetil Ameliorates Diabetic Nephropathy in db/db Mice
por: Seo, Jung-Woo, et al.
Publicado: (2015)

Dietary Leucine Supplement Ameliorates Hepatic Steatosis and Diabetic Nephropathy in db/db Mice
por: Chen, Kuan-Hsing, et al.
Publicado: (2018)

Increased Oxidative Damage of RNA in Early-Stage Nephropathy in db/db Mice
por: Wang, Wan-Xia, et al.
Publicado: (2017)

NaoXinTong Capsules inhibit the development of diabetic nephropathy in db/db mice
por: Yang, Shu, et al.
Publicado: (2018)

Nelumbo nucifera leaves extract attenuate the pathological progression of diabetic nephropathy in high-fat diet-fed and streptozotocin-induced diabetic rats
por: Chen, Huan-Wei, et al.
Publicado: (2019)

Proteases in Plasma and Kidney of db/db Mice as Markers of Diabetes-Induced Nephropathy
por: Hadler-Olsen, E., et al.
Publicado: (2011)

Galantamine improves glycemic control and diabetic nephropathy in Lepr(db/db) mice
por: Meng, Qinghe, et al.
Publicado: (2023)

Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy
por: Liu, Mengyang, et al.
Publicado: (2015)

Adiponectin retards the progression of diabetic nephropathy in db/db mice by counteracting angiotensin II
por: Guo, Xiaohua, et al.
Publicado: (2014)

Astragalus–Saffron–Rhubarb Mixture Delays the Progress of Diabetic Nephropathy in db/db Mice
por: Zhou, Xiao-Chun, et al.
Publicado: (2021)

Clopidogrel delays and can reverse diabetic nephropathy pathogenesis in type 2 diabetic db/db mice
por: Li, Hong-Qin, et al.
Publicado: (2022)

Fluorofenidone Offers Improved Renoprotection at Early Interventions during the Course of Diabetic Nephropathy in db/db Mice via Multiple Pathways
por: Xiong, Xuan, et al.
Publicado: (2014)

Mulberry Leaf (Morus alba L.) Extracts and Its Chlorogenic Acid Isomer Component Improve Glucolipotoxicity-Induced Hepatic Lipid Accumulation via Downregulating miR-34a and Decreased Inflammation
por: Yang, Tsung-Yuan, et al.
Publicado: (2022)

Overexpression of lipoic acid synthase gene alleviates diabetic nephropathy of Lepr(db/db) mice
por: Zhao, Yingzheng, et al.
Publicado: (2021)

Astragaloside IV ameliorates diabetic nephropathy in db/db mice by inhibiting NLRP3 inflammasome-mediated inflammation
por: Feng, Hui, et al.
Publicado: (2021)

Retinal Neurodegeneration in db/db Mice at the Early Period of Diabetes
por: Yang, Qin, et al.
Publicado: (2015)

MiR‐30c protects diabetic nephropathy by suppressing epithelial‐to‐mesenchymal transition in db/db mice
por: Zhao, Yanru, et al.
Publicado: (2017)

Glycyrrhizic Acid Prevents Diabetic Nephropathy by Activating AMPK/SIRT1/PGC-1α Signaling in db/db Mice
por: Hou, Shaozhang, et al.
Publicado: (2017)

Anti-Diabetic Nephropathy Activities of Polysaccharides Obtained from Termitornyces albuminosus via Regulation of NF-κB Signaling in db/db Mice
por: Yang, Chang, et al.
Publicado: (2019)

Dendrobium Mixture Ameliorates Diabetic Nephropathy in db/db Mice by Regulating the TGF-β1/Smads Signaling Pathway
por: Chen, Yong, et al.
Publicado: (2021)

Improvement of endothelial nitric oxide synthase activity retards the progression of diabetic nephropathy in db/db mice
por: Cheng, Huifang, et al.
Publicado: (2012)

Therapeutic Effects of Tangshen Formula on Diabetic Nephropathy in db/db Mice Using Cytokine Antibody Array
por: Fan, Xue Mei, et al.
Publicado: (2018)

Impact of sex on diabetic nephropathy and the renal transcriptome in UNx db/db C57BLKS mice
por: Sembach, Frederikke E., et al.
Publicado: (2019)

EW-7197 Attenuates the Progression of Diabetic Nephropathy in db/db Mice through Suppression of Fibrogenesis and Inflammation
por: Ha, Kyung Bong, et al.
Publicado: (2022)

Amelioration of diabetic nephropathy in db/db mice treated with tibetan medicine formula Siwei Jianghuang Decoction Powder extract
por: Lai, Xianrong, et al.
Publicado: (2018)

Cosmos DB for MongoDB developers: migrating to Azure Cosmos DB and using the MongoDB API
por: Sharma, Manish
Publicado: (2018)

Inhibition of lymphatic proliferation by the selective VEGFR-3 inhibitor SAR131675 ameliorates diabetic nephropathy in db/db mice
por: Hwang, Seun Deuk, et al.
Publicado: (2019)

Protective Effects of Astragaloside IV on db/db Mice with Diabetic Retinopathy
por: Ding, Yuzhi, et al.
Publicado: (2014)

Potent long-acting rhFGF21 analog for treatment of diabetic nephropathy in db/db and DIO mice
por: Zhao, Longwei, et al.
Publicado: (2017)

Sarpogrelate hydrochloride ameliorates diabetic nephropathy associated with inhibition of macrophage activity and inflammatory reaction in db/db mice
por: Lee, Eun Soo, et al.
Publicado: (2017)

Zuogui Wan ameliorates high glucose-induced podocyte apoptosis and improves diabetic nephropathy in db/db mice
por: Zhu, Bingbing, et al.
Publicado: (2022)

Antidiabetic and Antiobesity Effects of Artemether in db/db Mice
por: Guo, Yu, et al.
Publicado: (2018)

Pleiotropic effects of acarbose on atherosclerosis development in rabbits are mediated via upregulating AMPK signals
por: Chan, Kuei-Chuan, et al.
Publicado: (2016)

Irbesartan Ameliorates Diabetic Nephropathy by Suppressing the RANKL-RANK-NF-κB Pathway in Type 2 Diabetic db/db Mice
por: Chen, Xiao-Wen, et al.
Publicado: (2016)

Lipoprotein Lipase Inhibitor, Nordihydroguaiaretic Acid, Aggravates Metabolic Phenotypes and Alters HDL Particle Size in the Western Diet-Fed db/db Mice
por: Kang, Inhae, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_82a9ur5cmb1vephttjhpupnsjk