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The role of Mitochondrial Fission Proteins in Mitochondrial Dynamics in Kidney Disease
Mitochondria have many forms and can change their shape through fusion and fission of the outer and inner membranes, called “mitochondrial dynamics”. Mitochondrial outer membrane proteins, such as mitochondrial fission protein 1 (FIS1), mitochondrial fission factor (MFF), mitochondrial 98 dynamics p...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736104/ https://www.ncbi.nlm.nih.gov/pubmed/36499050 http://dx.doi.org/10.3390/ijms232314725 |
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author | Qin, Lingyu Xi, Shuhua |
author_facet | Qin, Lingyu Xi, Shuhua |
author_sort | Qin, Lingyu |
collection | PubMed |
description | Mitochondria have many forms and can change their shape through fusion and fission of the outer and inner membranes, called “mitochondrial dynamics”. Mitochondrial outer membrane proteins, such as mitochondrial fission protein 1 (FIS1), mitochondrial fission factor (MFF), mitochondrial 98 dynamics proteins of 49 kDa (MiD49), and mitochondrial dynamics proteins of 51 kDa (MiD51), can aggregate at the outer mitochondrial membrane and thus attract Dynamin-related protein 1 (DRP1) from the cytoplasm to the outer mitochondrial membrane, where DRP1 can perform a scissor-like function to cut a complete mitochondrion into two separate mitochondria. Other organelles can promote mitochondrial fission alongside mitochondria. FIS1 plays an important role in mitochondrial–lysosomal contacts, differentiating itself from other mitochondrial-fission-associated proteins. The contact between the two can also induce asymmetric mitochondrial fission. The kidney is a mitochondria-rich organ, requiring large amounts of mitochondria to produce energy for blood circulation and waste elimination. Pathological increases in mitochondrial fission can lead to kidney damage that can be ameliorated by suppressing their excessive fission. This article reviews the current knowledge on the key role of mitochondrial-fission-associated proteins in the pathogenesis of kidney injury and the role of their various post-translational modifications in activation or degradation of fission-associated proteins and targeted drug therapy. |
format | Online Article Text |
id | pubmed-9736104 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97361042022-12-11 The role of Mitochondrial Fission Proteins in Mitochondrial Dynamics in Kidney Disease Qin, Lingyu Xi, Shuhua Int J Mol Sci Review Mitochondria have many forms and can change their shape through fusion and fission of the outer and inner membranes, called “mitochondrial dynamics”. Mitochondrial outer membrane proteins, such as mitochondrial fission protein 1 (FIS1), mitochondrial fission factor (MFF), mitochondrial 98 dynamics proteins of 49 kDa (MiD49), and mitochondrial dynamics proteins of 51 kDa (MiD51), can aggregate at the outer mitochondrial membrane and thus attract Dynamin-related protein 1 (DRP1) from the cytoplasm to the outer mitochondrial membrane, where DRP1 can perform a scissor-like function to cut a complete mitochondrion into two separate mitochondria. Other organelles can promote mitochondrial fission alongside mitochondria. FIS1 plays an important role in mitochondrial–lysosomal contacts, differentiating itself from other mitochondrial-fission-associated proteins. The contact between the two can also induce asymmetric mitochondrial fission. The kidney is a mitochondria-rich organ, requiring large amounts of mitochondria to produce energy for blood circulation and waste elimination. Pathological increases in mitochondrial fission can lead to kidney damage that can be ameliorated by suppressing their excessive fission. This article reviews the current knowledge on the key role of mitochondrial-fission-associated proteins in the pathogenesis of kidney injury and the role of their various post-translational modifications in activation or degradation of fission-associated proteins and targeted drug therapy. MDPI 2022-11-25 /pmc/articles/PMC9736104/ /pubmed/36499050 http://dx.doi.org/10.3390/ijms232314725 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Qin, Lingyu Xi, Shuhua The role of Mitochondrial Fission Proteins in Mitochondrial Dynamics in Kidney Disease |
title | The role of Mitochondrial Fission Proteins in Mitochondrial Dynamics in Kidney Disease |
title_full | The role of Mitochondrial Fission Proteins in Mitochondrial Dynamics in Kidney Disease |
title_fullStr | The role of Mitochondrial Fission Proteins in Mitochondrial Dynamics in Kidney Disease |
title_full_unstemmed | The role of Mitochondrial Fission Proteins in Mitochondrial Dynamics in Kidney Disease |
title_short | The role of Mitochondrial Fission Proteins in Mitochondrial Dynamics in Kidney Disease |
title_sort | role of mitochondrial fission proteins in mitochondrial dynamics in kidney disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736104/ https://www.ncbi.nlm.nih.gov/pubmed/36499050 http://dx.doi.org/10.3390/ijms232314725 |
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