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Interaction of Depression and Unhealthy Diets on the Risk of Cardiovascular Diseases and All-Cause Mortality in the Chinese Population: A PURE Cohort Substudy

This study aimed to identify the interaction of depression and diets on cardiovascular diseases (CVD) incident and death in China and key subpopulations. We included 40,925 participants from the Prospective Urban Rural Epidemiology (PURE)-China cohort which recruited participants aged 35–70 years fr...

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Autores principales: Lang, Xinyue, Liu, Zhiguang, Islam, Shofiqul, Han, Guoliang, Rangarajan, Sumathy, Tse, Lap Ah, Mushtaha, Maha, Wang, Junying, Hu, Lihua, Qiang, Deren, Zhu, Yingxuan, Yusuf, Salim, Lin, Yang, Hu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736353/
https://www.ncbi.nlm.nih.gov/pubmed/36501202
http://dx.doi.org/10.3390/nu14235172
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author Lang, Xinyue
Liu, Zhiguang
Islam, Shofiqul
Han, Guoliang
Rangarajan, Sumathy
Tse, Lap Ah
Mushtaha, Maha
Wang, Junying
Hu, Lihua
Qiang, Deren
Zhu, Yingxuan
Yusuf, Salim
Lin, Yang
Hu, Bo
author_facet Lang, Xinyue
Liu, Zhiguang
Islam, Shofiqul
Han, Guoliang
Rangarajan, Sumathy
Tse, Lap Ah
Mushtaha, Maha
Wang, Junying
Hu, Lihua
Qiang, Deren
Zhu, Yingxuan
Yusuf, Salim
Lin, Yang
Hu, Bo
author_sort Lang, Xinyue
collection PubMed
description This study aimed to identify the interaction of depression and diets on cardiovascular diseases (CVD) incident and death in China and key subpopulations. We included 40,925 participants from the Prospective Urban Rural Epidemiology (PURE)-China cohort which recruited participants aged 35–70 years from 45 urban and 70 rural communities. Depression was measured by the adapted Short-Form (CIDI-SF). The unhealthy diet was considered when the score of Alternative Healthy Eating Index was below the lowest tertile. The primary outcome was a composite outcome of incident CVD and all-cause mortality. Cox frailty models were used to examine the associations. During a median follow-up of 11.9 years (IQR: 9.6–12.6 years), depression significantly increased the risk of the composite outcome (HR = 2.00; 95% CI, 1.16–3.27), major CVD (HR = 1.82; 95% CI, 1.48–2.23), and all-cause mortality (HR = 2.21; 95% CI, 1.51–3.24) for the unhealthy diet group, but not for the healthy diet group. The interaction between depression and diet for the composite outcome was statistically significant (RERI = 1.19; 95% CI, 0.66–1.72; AP = 0.42, 95% CI, 0.27–0.61; SI = 3.30, 95% CI, 1.42–7.66; multiplicative-scale = 1.74 95% CI, 1.27–2.39), even in the subgroup and sensitivity analyses. In addition, the intake of vegetable and polyunsaturated fatty acids contributed most to the interaction of diets and depression. Depressive participants should focus on healthy diets, especially vegetables and polyunsaturated fatty acids, to avoid premature death and CVD.
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spelling pubmed-97363532022-12-11 Interaction of Depression and Unhealthy Diets on the Risk of Cardiovascular Diseases and All-Cause Mortality in the Chinese Population: A PURE Cohort Substudy Lang, Xinyue Liu, Zhiguang Islam, Shofiqul Han, Guoliang Rangarajan, Sumathy Tse, Lap Ah Mushtaha, Maha Wang, Junying Hu, Lihua Qiang, Deren Zhu, Yingxuan Yusuf, Salim Lin, Yang Hu, Bo Nutrients Article This study aimed to identify the interaction of depression and diets on cardiovascular diseases (CVD) incident and death in China and key subpopulations. We included 40,925 participants from the Prospective Urban Rural Epidemiology (PURE)-China cohort which recruited participants aged 35–70 years from 45 urban and 70 rural communities. Depression was measured by the adapted Short-Form (CIDI-SF). The unhealthy diet was considered when the score of Alternative Healthy Eating Index was below the lowest tertile. The primary outcome was a composite outcome of incident CVD and all-cause mortality. Cox frailty models were used to examine the associations. During a median follow-up of 11.9 years (IQR: 9.6–12.6 years), depression significantly increased the risk of the composite outcome (HR = 2.00; 95% CI, 1.16–3.27), major CVD (HR = 1.82; 95% CI, 1.48–2.23), and all-cause mortality (HR = 2.21; 95% CI, 1.51–3.24) for the unhealthy diet group, but not for the healthy diet group. The interaction between depression and diet for the composite outcome was statistically significant (RERI = 1.19; 95% CI, 0.66–1.72; AP = 0.42, 95% CI, 0.27–0.61; SI = 3.30, 95% CI, 1.42–7.66; multiplicative-scale = 1.74 95% CI, 1.27–2.39), even in the subgroup and sensitivity analyses. In addition, the intake of vegetable and polyunsaturated fatty acids contributed most to the interaction of diets and depression. Depressive participants should focus on healthy diets, especially vegetables and polyunsaturated fatty acids, to avoid premature death and CVD. MDPI 2022-12-05 /pmc/articles/PMC9736353/ /pubmed/36501202 http://dx.doi.org/10.3390/nu14235172 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lang, Xinyue
Liu, Zhiguang
Islam, Shofiqul
Han, Guoliang
Rangarajan, Sumathy
Tse, Lap Ah
Mushtaha, Maha
Wang, Junying
Hu, Lihua
Qiang, Deren
Zhu, Yingxuan
Yusuf, Salim
Lin, Yang
Hu, Bo
Interaction of Depression and Unhealthy Diets on the Risk of Cardiovascular Diseases and All-Cause Mortality in the Chinese Population: A PURE Cohort Substudy
title Interaction of Depression and Unhealthy Diets on the Risk of Cardiovascular Diseases and All-Cause Mortality in the Chinese Population: A PURE Cohort Substudy
title_full Interaction of Depression and Unhealthy Diets on the Risk of Cardiovascular Diseases and All-Cause Mortality in the Chinese Population: A PURE Cohort Substudy
title_fullStr Interaction of Depression and Unhealthy Diets on the Risk of Cardiovascular Diseases and All-Cause Mortality in the Chinese Population: A PURE Cohort Substudy
title_full_unstemmed Interaction of Depression and Unhealthy Diets on the Risk of Cardiovascular Diseases and All-Cause Mortality in the Chinese Population: A PURE Cohort Substudy
title_short Interaction of Depression and Unhealthy Diets on the Risk of Cardiovascular Diseases and All-Cause Mortality in the Chinese Population: A PURE Cohort Substudy
title_sort interaction of depression and unhealthy diets on the risk of cardiovascular diseases and all-cause mortality in the chinese population: a pure cohort substudy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736353/
https://www.ncbi.nlm.nih.gov/pubmed/36501202
http://dx.doi.org/10.3390/nu14235172
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