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Antibacterial Activity of Two Zn-MOFs Containing a Tricarboxylate Linker

Metal–organic frameworks (MOFs) can be used as reservoirs of metal ions with relevant antibacterial effects. Here, two novel Zn-based MOFs with the formulas [Zn(4)(μ(4)-O)(μ-FA)L(2)] (GR-MOF-8) and [Zn(4)(μ(4)-O)L(2)(H(2)O)] (GR-MOF-9) (H(3)L: 5-((4-carboxyphenyl)ethynyl) in isophthalic acid and FA...

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Autores principales: Rojas, Sara, García-García, Amalia, Hidalgo, Tania, Rosales, María, Ruiz-Camino, Daniel, Salcedo-Abraira, Pablo, Montes-Andrés, Helena, Choquesillo-Lazarte, Duane, Rosal, Roberto, Horcajada, Patricia, Rodríguez-Diéguez, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736432/
https://www.ncbi.nlm.nih.gov/pubmed/36500760
http://dx.doi.org/10.3390/nano12234139
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author Rojas, Sara
García-García, Amalia
Hidalgo, Tania
Rosales, María
Ruiz-Camino, Daniel
Salcedo-Abraira, Pablo
Montes-Andrés, Helena
Choquesillo-Lazarte, Duane
Rosal, Roberto
Horcajada, Patricia
Rodríguez-Diéguez, Antonio
author_facet Rojas, Sara
García-García, Amalia
Hidalgo, Tania
Rosales, María
Ruiz-Camino, Daniel
Salcedo-Abraira, Pablo
Montes-Andrés, Helena
Choquesillo-Lazarte, Duane
Rosal, Roberto
Horcajada, Patricia
Rodríguez-Diéguez, Antonio
author_sort Rojas, Sara
collection PubMed
description Metal–organic frameworks (MOFs) can be used as reservoirs of metal ions with relevant antibacterial effects. Here, two novel Zn-based MOFs with the formulas [Zn(4)(μ(4)-O)(μ-FA)L(2)] (GR-MOF-8) and [Zn(4)(μ(4)-O)L(2)(H(2)O)] (GR-MOF-9) (H(3)L: 5-((4-carboxyphenyl)ethynyl) in isophthalic acid and FA (formate anion) were solvothermally synthetized and fully characterized. The antibacterial activity of GR-MOF-8 and 9 was investigated against Staphylococcus aureus (SA) and Escherichia Coli (EC) by the agar diffusion method. Both bacteria are among the most relevant human and animal pathogens, causing a wide variety of infections, and are often related with the development of antimicrobial resistances. While both Zn-based materials exhibited antibacterial activity against both strains, GR-MOF-8 showed the highest inhibitory action, likely due to a more progressive Zn release under the tested experimental conditions. This is particularly evidenced in the inhibition of SA, with an increasing effect of GR-MOF-8 with time, which is of great significance to ensure the disappearance of the microorganism.
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spelling pubmed-97364322022-12-11 Antibacterial Activity of Two Zn-MOFs Containing a Tricarboxylate Linker Rojas, Sara García-García, Amalia Hidalgo, Tania Rosales, María Ruiz-Camino, Daniel Salcedo-Abraira, Pablo Montes-Andrés, Helena Choquesillo-Lazarte, Duane Rosal, Roberto Horcajada, Patricia Rodríguez-Diéguez, Antonio Nanomaterials (Basel) Article Metal–organic frameworks (MOFs) can be used as reservoirs of metal ions with relevant antibacterial effects. Here, two novel Zn-based MOFs with the formulas [Zn(4)(μ(4)-O)(μ-FA)L(2)] (GR-MOF-8) and [Zn(4)(μ(4)-O)L(2)(H(2)O)] (GR-MOF-9) (H(3)L: 5-((4-carboxyphenyl)ethynyl) in isophthalic acid and FA (formate anion) were solvothermally synthetized and fully characterized. The antibacterial activity of GR-MOF-8 and 9 was investigated against Staphylococcus aureus (SA) and Escherichia Coli (EC) by the agar diffusion method. Both bacteria are among the most relevant human and animal pathogens, causing a wide variety of infections, and are often related with the development of antimicrobial resistances. While both Zn-based materials exhibited antibacterial activity against both strains, GR-MOF-8 showed the highest inhibitory action, likely due to a more progressive Zn release under the tested experimental conditions. This is particularly evidenced in the inhibition of SA, with an increasing effect of GR-MOF-8 with time, which is of great significance to ensure the disappearance of the microorganism. MDPI 2022-11-23 /pmc/articles/PMC9736432/ /pubmed/36500760 http://dx.doi.org/10.3390/nano12234139 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rojas, Sara
García-García, Amalia
Hidalgo, Tania
Rosales, María
Ruiz-Camino, Daniel
Salcedo-Abraira, Pablo
Montes-Andrés, Helena
Choquesillo-Lazarte, Duane
Rosal, Roberto
Horcajada, Patricia
Rodríguez-Diéguez, Antonio
Antibacterial Activity of Two Zn-MOFs Containing a Tricarboxylate Linker
title Antibacterial Activity of Two Zn-MOFs Containing a Tricarboxylate Linker
title_full Antibacterial Activity of Two Zn-MOFs Containing a Tricarboxylate Linker
title_fullStr Antibacterial Activity of Two Zn-MOFs Containing a Tricarboxylate Linker
title_full_unstemmed Antibacterial Activity of Two Zn-MOFs Containing a Tricarboxylate Linker
title_short Antibacterial Activity of Two Zn-MOFs Containing a Tricarboxylate Linker
title_sort antibacterial activity of two zn-mofs containing a tricarboxylate linker
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736432/
https://www.ncbi.nlm.nih.gov/pubmed/36500760
http://dx.doi.org/10.3390/nano12234139
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