Cargando…

Advances in the Understanding of Two-Pore Domain TASK Potassium Channels and Their Potential as Therapeutic Targets

TWIK-related acid-sensitive K(+) (TASK) channels, including TASK-1, TASK-3, and TASK-5, are important members of the two-pore domain potassium (K(2P)) channel family. TASK-5 is not functionally expressed in the recombinant system. TASK channels are very sensitive to changes in extracellular pH and a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fan, Xueming, Lu, Yongzhi, Du, Guizhi, Liu, Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736439/ https://www.ncbi.nlm.nih.gov/pubmed/36500386 http://dx.doi.org/10.3390/molecules27238296

Ejemplares similares

Two-pore Domain Potassium Channels in Astrocytes
por: Ryoo, Kanghyun, et al.
Publicado: (2016)

A Specific Two-pore Domain Potassium Channel Blocker Defines the Structure of the TASK-1 Open Pore
por: Streit, Anne K., et al.
Publicado: (2011)

Trafficking of Neuronal Two Pore Domain Potassium Channels
por: Mathie, Alistair, et al.
Publicado: (2010)

Two-pore domain potassium channels in the adrenal cortex
por: Bandulik, Sascha, et al.
Publicado: (2014)

Development of Non-opioid Analgesics Targeting Two-pore Domain Potassium Channels
por: Huang, Lu, et al.
Publicado: (2022)

Two-pore domain potassium channels enable action potential generation in the absence of voltage-gated potassium channels
por: MacKenzie, Georgina, et al.
Publicado: (2014)

Characterization and regulation of wild‐type and mutant TASK‐1 two pore domain potassium channels indicated in pulmonary arterial hypertension
por: Cunningham, Kevin P., et al.
Publicado: (2018)

The pungent substances piperine, capsaicin, 6-gingerol and polygodial inhibit the human two-pore domain potassium channels TASK-1, TASK-3 and TRESK
por: Beltrán, Leopoldo R., et al.
Publicado: (2013)

Altered Expression of Two-Pore Domain Potassium (K(2P)) Channels in Cancer
por: Williams, Sarah, et al.
Publicado: (2013)

Contribution of Neuronal and Glial Two-Pore-Domain Potassium Channels in Health and Neurological Disorders
por: Luo, Yuncheng, et al.
Publicado: (2021)

A “Target Class” Screen to Identify Activators of Two-Pore Domain Potassium (K2P) Channels
por: McCoull, David, et al.
Publicado: (2020)

Differential modulation of C. elegans motor behavior by NALCN and two-pore domain potassium channels
por: Zhou, Chuanman, et al.
Publicado: (2022)

Two pore domain potassium channels in cerebral ischemia: a focus on K(2P)9.1 (TASK3, KCNK9)
por: Ehling, Petra, et al.
Publicado: (2010)

Correction: Two pore domain potassium channels in cerebral ischemia: a focus on K2P9.1 (TASK3, KCNK9)
por: Ehling, Petra, et al.
Publicado: (2013)

Convergent effects of multiple modulators on two-pore-domain 'leak' potassium channels in respiratory-related neurons
por: Talley, EM, et al.
Publicado: (2001)

Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels
por: Ben Soussia, Ismail, et al.
Publicado: (2019)

Alkaline-sensitive two-pore domain potassium channels form functional heteromers in pancreatic β-cells
por: Khoubza, Lamyaa, et al.
Publicado: (2022)

The voltage-sensing domain of a phosphatase gates the pore of a potassium channel
por: Arrigoni, Cristina, et al.
Publicado: (2013)

Endocytosis as a mode to regulate functional expression of two-pore domain potassium (K(2P)) channels
por: O’Kelly, Ita
Publicado: (2014)

Regulation of the two-pore domain potassium channel, THIK-1 and THIK-2, by G protein coupled receptors
por: Tateyama, Michihiro, et al.
Publicado: (2023)

Electrostatics and the Gating Pore of Shaker Potassium Channels
por: Islas, Leon D., et al.
Publicado: (2001)

Pore size matters for potassium channel conductance
por: Naranjo, David, et al.
Publicado: (2016)

Expression and localisation of two-pore domain (K2P) background leak potassium ion channels in the mouse retina
por: Hughes, Steven, et al.
Publicado: (2017)

Two-Pore-Domain Potassium (K(2P)-) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes
por: Wiedmann, Felix, et al.
Publicado: (2021)

Domain assembly of NAADP-gated two-pore channels
por: Churamani, Dev, et al.
Publicado: (2011)

Evaluation of the Ion Channel Assembly in a Eukaryotic Cell-Free System Focusing on Two-Pore Domain Potassium Channels K(2P)
por: Ullrich, Jessica, et al.
Publicado: (2023)

Myometrial relaxation of mice via expression of two pore domain acid sensitive K(+) (TASK-2) channels
por: Kyeong, Kyu-Sang, et al.
Publicado: (2016)

Heterodimerization of two pore domain K(+) channel TASK1 and TALK2 in living heterologous expression systems
por: Suzuki, Yoshiaki, et al.
Publicado: (2017)

Long-pore Electrostatics in Inward-rectifier Potassium Channels
por: Robertson, Janice L., et al.
Publicado: (2008)

Potassium channels as multi-ion single-file pores
Publicado: (1978)

Tandem pore TWIK-related potassium channels and neuroprotection
por: Lamas, J. Antonio, et al.
Publicado: (2019)

Potassium-dependent Changes in the Conformation of the Kv2.1 Potassium Channel Pore
por: Immke, David, et al.
Publicado: (1999)

Intersubunit Concerted Cooperative and cis-Type Mechanisms Modulate Allosteric Gating in Two-Pore-Domain Potassium Channel TREK-2
por: Zhuo, Ren-Gong, et al.
Publicado: (2016)

Molecular Modeling of a Tandem Two Pore Domain Potassium Channel Reveals a Putative Binding Site for General Anesthetics
por: Bertaccini, Edward J., et al.
Publicado: (2014)

TREK-TRAAK two-pore domain potassium channels protect human retinal pigment epithelium cells from oxidative stress
por: Huang, Hao, et al.
Publicado: (2018)

Effect of 158 herbal remedies on human TRPV1 and the two-pore domain potassium channels KCNK2, 3 and 9
por: Herbrechter, Robin, et al.
Publicado: (2020)

Contribution of TRESK two-pore domain potassium channel to bone cancer-induced spontaneous pain and evoked cutaneous pain in rats
por: Liu, Jiang-Ping, et al.
Publicado: (2021)

Synergistic effects of agonists and two-pore-domain potassium channels on secretory responses of human pancreatic duct cells Capan-1
por: Sørensen, Christiane E., et al.
Publicado: (2022)

Expression of Stretch-Activated Two-Pore Potassium Channels in Human Myometrium in Pregnancy and Labor
por: Buxton, Iain L. O., et al.
Publicado: (2010)

The two pore potassium channel THIK‐1 regulates NLRP3 inflammasome activation
por: Drinkall, Samuel, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_dj8gnpgvdasavud2gd6jmadq6s