Development of Phosphoramidite Reagents for the Synthesis of Base-Labile Oligonucleotides Modified with a Linear Aminoalkyl and Amino-PEG Linker at the 3′-End

Oligonucleotides with an amino linker at the 3′-end are useful for the preparation of conjugated oligonucleotides. However, chemically modified nucleosides, which are unstable under basic conditions, cannot be incorporated into oligonucleotides using the conventional method entailing the preparation...

Descripción completa

Detalles Bibliográficos
Autores principales: Osawa, Takashi, Ren, Qin, Obika, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736658/
https://www.ncbi.nlm.nih.gov/pubmed/36500594
http://dx.doi.org/10.3390/molecules27238501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736658/
https://www.ncbi.nlm.nih.gov/pubmed/36500594
http://dx.doi.org/10.3390/molecules27238501

Ejemplares similares