Cargando…

Properties and Potential Antiproliferative Activity of Thrombin-Binding Aptamer (TBA) Derivatives with One or Two Additional G-Tetrads

In this paper, we study the biological properties of two TBA analogs containing one and two extra G-tetrads, namely TBAG3 and TBAG4, respectively, and two further derivatives in which one of the small loops at the bottom (TBAG41S) or the large loop at the top (TBAG4GS) of the TBAG4 structure has bee...

Descripción completa

Detalles Bibliográficos
Autores principales:	Benigno, Daniela, Virgilio, Antonella, Bello, Ivana, La Manna, Sara, Vellecco, Valentina, Bucci, Mariarosaria, Marasco, Daniela, Panza, Elisabetta, Esposito, Veronica, Galeone, Aldo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736779/ https://www.ncbi.nlm.nih.gov/pubmed/36499249 http://dx.doi.org/10.3390/ijms232314921

Ejemplares similares

Structural properties and anticoagulant/cytotoxic activities of heterochiral enantiomeric thrombin binding aptamer (TBA) derivatives
por: Virgilio, Antonella, et al.
Publicado: (2020)

Investigating the properties of TBA variants with twin thrombin binding domains
por: Amato, Teresa, et al.
Publicado: (2019)

Improving the Biological Properties of Thrombin-Binding Aptamer by Incorporation of 8-Bromo-2′-Deoxyguanosine and 2′-Substituted RNA Analogues
por: Virgilio, Antonella, et al.
Publicado: (2023)

Structural and Biological Features of G-Quadruplex Aptamers as Promising Inhibitors of the STAT3 Signaling Pathway
por: Esposito, Veronica, et al.
Publicado: (2023)

Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative
por: Scuotto, Maria, et al.
Publicado: (2015)

Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity
por: Virgilio, Antonella, et al.
Publicado: (2015)

Antiproliferative Effects of the Aptamer d(GGGT)(4) and Its Analogues with an Abasic-Site Mimic Loop on Different Cancer Cells
por: Virgilio, Antonella, et al.
Publicado: (2022)

Structural and Binding Effects of Chemical Modifications on Thrombin Binding Aptamer (TBA)
por: Valsangkar, Vibhav, et al.
Publicado: (2021)

uL3 Mediated Nucleolar Stress Pathway as a New Mechanism of Action of Antiproliferative G-quadruplex TBA Derivatives in Colon Cancer Cells
por: Pecoraro, Annalisa, et al.
Publicado: (2020)

A new modified thrombin binding aptamer containing a 5′–5′ inversion of polarity site
por: Martino, Luigi, et al.
Publicado: (2006)

TBA
por: Schuster, Stephan
Publicado: (2010)

TBA
por: Thompson, Craig
Publicado: (2010)

TBA
por: Clamp, Michele
Publicado: (2010)

Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative
por: Kotkowiak, Weronika, et al.
Publicado: (2017)

Exploring New Potential Anticancer Activities of the G-Quadruplexes Formed by [(GTG(2)T(G(3)T)(3)] and Its Derivatives with an Abasic Site Replacing Single Thymidine
por: Virgilio, Antonella, et al.
Publicado: (2021)

Probing the Importance of the G-Quadruplex Grooves for the Activity of the Anti-HIV-Integrase Aptamer T30923
por: Esposito, Veronica, et al.
Publicado: (2020)

Discovering New G-Quadruplex DNA Catalysts in Enantioselective Sulfoxidation Reaction
por: Festa, Carmen, et al.
Publicado: (2022)

Perthamide C Inhibits eNOS and iNOS Expression and Has Immunomodulating Activity In Vivo
por: Bucci, Mariarosaria, et al.
Publicado: (2013)

Study of Modified TBA Driver Scheme
por: Elzhov, A V, et al.
Publicado: (1999)

CLIC/RK-TBA Collaboration Meeting
Publicado: (1996)

A new chamber for beamline experiments (TBA)
por: Thiesbrummel, Jarla
Publicado: (2018)

Title TBA: Revising the Abstract Submission Process
por: Tibon, Roni, et al.
Publicado: (2018)

TBA-7 is not a microtubule-destabilizing tubulin
por: Lu, Yu-Ming, et al.
Publicado: (2021)

Aptamers Against the β-Conglutin Allergen: Insights into the Behavior of the Shortest Multimeric(Intra)Molecular DNA G-Quadruplex
por: O’ Sullivan, Ciara K., et al.
Publicado: (2021)

Follicular occlusion tetrad
por: Vasanth, Vani, et al.
Publicado: (2014)

Thrombin–aptamer recognition: a revealed ambiguity
por: Russo Krauss, Irene, et al.
Publicado: (2011)

Aptamer Based Microsphere Biosensor for Thrombin Detection
por: Zhu, Hongying, et al.
Publicado: (2006)

Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA)
por: Song, Ju Yeun, et al.
Publicado: (2020)

Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA)
por: Song, Ju Yeun, et al.
Publicado: (2020)

High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity
por: Russo Krauss, Irene, et al.
Publicado: (2012)

Traditional Birth Attendance (TBA) in a health system: what are the roles, benefits and challenges: A case study of incorporated TBA in Timor-Leste
por: Ribeiro Sarmento, Decio
Publicado: (2014)

Improvement of the activity of the anti-HIV-1 integrase aptamer T30175 by introducing a modified thymidine into the loops
por: Virgilio, Antonella, et al.
Publicado: (2018)

The tetrad frame constraint algebra
por: Clayton, M.A.
Publicado: (1996)

High-throughput Tetrad Analysis
por: Ludlow, Catherine L., et al.
Publicado: (2013)

Non-G Base Tetrads
por: Escaja, Núria, et al.
Publicado: (2022)

Development and Optimization of a Thrombin Sandwich Aptamer Microarray
por: Meneghello, Anna, et al.
Publicado: (2012)

Alpha-Deoxyguanosine to Reshape the Alpha-Thrombin Binding Aptamer
por: Kolganova, Natalia A., et al.
Publicado: (2023)

Conceptual design of a linear collider in the TBA/FEL regime
por: Hiramatsu, S, et al.
Publicado: (1990)

A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers
por: Troisi, Romualdo, et al.
Publicado: (2022)

Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity
por: Dolot, Rafal, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_a1due1qf6puig0i0uno67tcghh