Mitochondrial Control in Inflammatory Gastrointestinal Diseases

Mitochondria play a central role in the pathophysiology of inflammatory bowel disease (IBD) and colorectal cancer (CRC). The maintenance of mitochondrial function is necessary for a stable immune system. Mitochondrial dysfunction in the gastrointestinal system leads to the excessive activation of mu...

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Detalles Bibliográficos
Autores principales: Sui, Guo-Yan, Wang, Feng, Lee, Jin, Roh, Yoon Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736936/
https://www.ncbi.nlm.nih.gov/pubmed/36499214
http://dx.doi.org/10.3390/ijms232314890
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author Sui, Guo-Yan
Wang, Feng
Lee, Jin
Roh, Yoon Seok
author_facet Sui, Guo-Yan
Wang, Feng
Lee, Jin
Roh, Yoon Seok
author_sort Sui, Guo-Yan
collection PubMed
description Mitochondria play a central role in the pathophysiology of inflammatory bowel disease (IBD) and colorectal cancer (CRC). The maintenance of mitochondrial function is necessary for a stable immune system. Mitochondrial dysfunction in the gastrointestinal system leads to the excessive activation of multiple inflammatory signaling pathways, leading to IBD and increased severity of CRC. In this review, we focus on the mitochondria and inflammatory signaling pathways and its related gastrointestinal diseases.
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spelling pubmed-97369362022-12-11 Mitochondrial Control in Inflammatory Gastrointestinal Diseases Sui, Guo-Yan Wang, Feng Lee, Jin Roh, Yoon Seok Int J Mol Sci Review Mitochondria play a central role in the pathophysiology of inflammatory bowel disease (IBD) and colorectal cancer (CRC). The maintenance of mitochondrial function is necessary for a stable immune system. Mitochondrial dysfunction in the gastrointestinal system leads to the excessive activation of multiple inflammatory signaling pathways, leading to IBD and increased severity of CRC. In this review, we focus on the mitochondria and inflammatory signaling pathways and its related gastrointestinal diseases. MDPI 2022-11-28 /pmc/articles/PMC9736936/ /pubmed/36499214 http://dx.doi.org/10.3390/ijms232314890 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sui, Guo-Yan
Wang, Feng
Lee, Jin
Roh, Yoon Seok
Mitochondrial Control in Inflammatory Gastrointestinal Diseases
title Mitochondrial Control in Inflammatory Gastrointestinal Diseases
title_full Mitochondrial Control in Inflammatory Gastrointestinal Diseases
title_fullStr Mitochondrial Control in Inflammatory Gastrointestinal Diseases
title_full_unstemmed Mitochondrial Control in Inflammatory Gastrointestinal Diseases
title_short Mitochondrial Control in Inflammatory Gastrointestinal Diseases
title_sort mitochondrial control in inflammatory gastrointestinal diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736936/
https://www.ncbi.nlm.nih.gov/pubmed/36499214
http://dx.doi.org/10.3390/ijms232314890
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