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Hippocampal parvalbumin interneurons play a critical role in memory development

Episodic memories formed in early childhood rapidly decay, but their latent traces remain stored long term. These memories require the dorsal hippocampus (dHPC) and seem to undergo a developmental critical period. It remains to be determined whether the maturation of parvalbumin interneurons (PVIs),...

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Autores principales: Miranda, Janelle M., Cruz, Emmanuel, Bessières, Benjamin, Alberini, Cristina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737056/
https://www.ncbi.nlm.nih.gov/pubmed/36384113
http://dx.doi.org/10.1016/j.celrep.2022.111643
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author Miranda, Janelle M.
Cruz, Emmanuel
Bessières, Benjamin
Alberini, Cristina M.
author_facet Miranda, Janelle M.
Cruz, Emmanuel
Bessières, Benjamin
Alberini, Cristina M.
author_sort Miranda, Janelle M.
collection PubMed
description Episodic memories formed in early childhood rapidly decay, but their latent traces remain stored long term. These memories require the dorsal hippocampus (dHPC) and seem to undergo a developmental critical period. It remains to be determined whether the maturation of parvalbumin interneurons (PVIs), a major mechanism of critical periods, contributes to memory development. Here, we show that episodic infantile learning significantly increases the levels of parvalbumin in the dHPC 48 h after training. Chemogenetic inhibition of PVIs before learning indicated that these neurons are required for infantile memory formation. A bilateral dHPC injection of the γ-aminobutyric acid type A receptor agonist diazepam after training elicited long-term memory expression in infant rats, although direct PVI chemogenetic activation had no effect. Finally, PVI activity was required for brain-derived neurotrophic factor (BDNF)-dependent maturation of memory competence, i.e., adult-like long-term memory expression. Thus, dHPC PVIs are critical for the formation of infantile memories and for memory development.
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spelling pubmed-97370562022-12-10 Hippocampal parvalbumin interneurons play a critical role in memory development Miranda, Janelle M. Cruz, Emmanuel Bessières, Benjamin Alberini, Cristina M. Cell Rep Article Episodic memories formed in early childhood rapidly decay, but their latent traces remain stored long term. These memories require the dorsal hippocampus (dHPC) and seem to undergo a developmental critical period. It remains to be determined whether the maturation of parvalbumin interneurons (PVIs), a major mechanism of critical periods, contributes to memory development. Here, we show that episodic infantile learning significantly increases the levels of parvalbumin in the dHPC 48 h after training. Chemogenetic inhibition of PVIs before learning indicated that these neurons are required for infantile memory formation. A bilateral dHPC injection of the γ-aminobutyric acid type A receptor agonist diazepam after training elicited long-term memory expression in infant rats, although direct PVI chemogenetic activation had no effect. Finally, PVI activity was required for brain-derived neurotrophic factor (BDNF)-dependent maturation of memory competence, i.e., adult-like long-term memory expression. Thus, dHPC PVIs are critical for the formation of infantile memories and for memory development. 2022-11-15 /pmc/articles/PMC9737056/ /pubmed/36384113 http://dx.doi.org/10.1016/j.celrep.2022.111643 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Miranda, Janelle M.
Cruz, Emmanuel
Bessières, Benjamin
Alberini, Cristina M.
Hippocampal parvalbumin interneurons play a critical role in memory development
title Hippocampal parvalbumin interneurons play a critical role in memory development
title_full Hippocampal parvalbumin interneurons play a critical role in memory development
title_fullStr Hippocampal parvalbumin interneurons play a critical role in memory development
title_full_unstemmed Hippocampal parvalbumin interneurons play a critical role in memory development
title_short Hippocampal parvalbumin interneurons play a critical role in memory development
title_sort hippocampal parvalbumin interneurons play a critical role in memory development
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737056/
https://www.ncbi.nlm.nih.gov/pubmed/36384113
http://dx.doi.org/10.1016/j.celrep.2022.111643
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