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Natural Astaxanthin Is a Green Antioxidant Able to Counteract Lipid Peroxidation and Ferroptotic Cell Death
Astaxanthin is a red orange xanthophyll carotenoid produced mainly by microalgae but which can also be chemically synthesized. As demonstrated by several studies, this lipophilic molecule is endowed with potent antioxidant properties and is able to modulate biological functions. Unlike synthetic ast...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737268/ https://www.ncbi.nlm.nih.gov/pubmed/36499464 http://dx.doi.org/10.3390/ijms232315137 |
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author | Rizzardi, Nicola Pezzolesi, Laura Samorì, Chiara Senese, Federica Zalambani, Chiara Pitacco, Walter Calonghi, Natalia Bergamini, Christian Prata, Cecilia Fato, Romana |
author_facet | Rizzardi, Nicola Pezzolesi, Laura Samorì, Chiara Senese, Federica Zalambani, Chiara Pitacco, Walter Calonghi, Natalia Bergamini, Christian Prata, Cecilia Fato, Romana |
author_sort | Rizzardi, Nicola |
collection | PubMed |
description | Astaxanthin is a red orange xanthophyll carotenoid produced mainly by microalgae but which can also be chemically synthesized. As demonstrated by several studies, this lipophilic molecule is endowed with potent antioxidant properties and is able to modulate biological functions. Unlike synthetic astaxanthin, natural astaxanthin (NAst) is considered safe for human nutrition, and its production is considered eco-friendly. The antioxidant activity of astaxanthin depends on its bioavailability, which, in turn, is related to its hydrophobicity. In this study, we analyzed the water-solubility of NAst and assessed its protective effect against oxidative stress by means of different approaches using a neuroblastoma cell model. Moreover, due to its highly lipophilic nature, astaxanthin is particularly protective against lipid peroxidation; therefore, the role of NAst in counteracting ferroptosis was investigated. This recently discovered process of programmed cell death is indeed characterized by iron-dependent lipid peroxidation and seems to be linked to the onset and development of oxidative-stress-related diseases. The promising results of this study, together with the “green sources” from which astaxanthin could derive, suggest a potential role for NAst in the prevention and co-treatment of chronic degenerative diseases by means of a sustainable approach. |
format | Online Article Text |
id | pubmed-9737268 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97372682022-12-11 Natural Astaxanthin Is a Green Antioxidant Able to Counteract Lipid Peroxidation and Ferroptotic Cell Death Rizzardi, Nicola Pezzolesi, Laura Samorì, Chiara Senese, Federica Zalambani, Chiara Pitacco, Walter Calonghi, Natalia Bergamini, Christian Prata, Cecilia Fato, Romana Int J Mol Sci Article Astaxanthin is a red orange xanthophyll carotenoid produced mainly by microalgae but which can also be chemically synthesized. As demonstrated by several studies, this lipophilic molecule is endowed with potent antioxidant properties and is able to modulate biological functions. Unlike synthetic astaxanthin, natural astaxanthin (NAst) is considered safe for human nutrition, and its production is considered eco-friendly. The antioxidant activity of astaxanthin depends on its bioavailability, which, in turn, is related to its hydrophobicity. In this study, we analyzed the water-solubility of NAst and assessed its protective effect against oxidative stress by means of different approaches using a neuroblastoma cell model. Moreover, due to its highly lipophilic nature, astaxanthin is particularly protective against lipid peroxidation; therefore, the role of NAst in counteracting ferroptosis was investigated. This recently discovered process of programmed cell death is indeed characterized by iron-dependent lipid peroxidation and seems to be linked to the onset and development of oxidative-stress-related diseases. The promising results of this study, together with the “green sources” from which astaxanthin could derive, suggest a potential role for NAst in the prevention and co-treatment of chronic degenerative diseases by means of a sustainable approach. MDPI 2022-12-01 /pmc/articles/PMC9737268/ /pubmed/36499464 http://dx.doi.org/10.3390/ijms232315137 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rizzardi, Nicola Pezzolesi, Laura Samorì, Chiara Senese, Federica Zalambani, Chiara Pitacco, Walter Calonghi, Natalia Bergamini, Christian Prata, Cecilia Fato, Romana Natural Astaxanthin Is a Green Antioxidant Able to Counteract Lipid Peroxidation and Ferroptotic Cell Death |
title | Natural Astaxanthin Is a Green Antioxidant Able to Counteract Lipid Peroxidation and Ferroptotic Cell Death |
title_full | Natural Astaxanthin Is a Green Antioxidant Able to Counteract Lipid Peroxidation and Ferroptotic Cell Death |
title_fullStr | Natural Astaxanthin Is a Green Antioxidant Able to Counteract Lipid Peroxidation and Ferroptotic Cell Death |
title_full_unstemmed | Natural Astaxanthin Is a Green Antioxidant Able to Counteract Lipid Peroxidation and Ferroptotic Cell Death |
title_short | Natural Astaxanthin Is a Green Antioxidant Able to Counteract Lipid Peroxidation and Ferroptotic Cell Death |
title_sort | natural astaxanthin is a green antioxidant able to counteract lipid peroxidation and ferroptotic cell death |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737268/ https://www.ncbi.nlm.nih.gov/pubmed/36499464 http://dx.doi.org/10.3390/ijms232315137 |
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