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Tellurium-Modified Nucleosides, Nucleotides, and Nucleic Acids with Potential Applications

Tellurium was successfully incorporated into proteins and applied to protein structure determination through X-ray crystallography. However, studies on tellurium modification of DNA and RNA are limited. This review highlights the recent development of Te-modified nucleosides, nucleotides, and nuclei...

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Autores principales: Chen, Cen, Huang, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737395/
https://www.ncbi.nlm.nih.gov/pubmed/36500495
http://dx.doi.org/10.3390/molecules27238379
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author Chen, Cen
Huang, Zhen
author_facet Chen, Cen
Huang, Zhen
author_sort Chen, Cen
collection PubMed
description Tellurium was successfully incorporated into proteins and applied to protein structure determination through X-ray crystallography. However, studies on tellurium modification of DNA and RNA are limited. This review highlights the recent development of Te-modified nucleosides, nucleotides, and nucleic acids, and summarizes the main synthetic approaches for the preparation of 5-PhTe, 2′-MeTe, and 2′-PhTe modifications. Those modifications are compatible with solid-phase synthesis and stable during Te-oligonucleotide purification. Moreover, the ideal electronic and atomic properties of tellurium for generating clear isomorphous signals give Te-modified DNA and RNA great potential applications in 3D crystal structure determination through X-ray diffraction. STM study also shows that Te-modified DNA has strong topographic and current peaks, which immediately suggests potential applications in nucleic acid direct imaging, nanomaterials, molecular electronics, and diagnostics. Theoretical studies indicate the potential application of Te-modified nucleosides in cancer therapy.
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spelling pubmed-97373952022-12-11 Tellurium-Modified Nucleosides, Nucleotides, and Nucleic Acids with Potential Applications Chen, Cen Huang, Zhen Molecules Perspective Tellurium was successfully incorporated into proteins and applied to protein structure determination through X-ray crystallography. However, studies on tellurium modification of DNA and RNA are limited. This review highlights the recent development of Te-modified nucleosides, nucleotides, and nucleic acids, and summarizes the main synthetic approaches for the preparation of 5-PhTe, 2′-MeTe, and 2′-PhTe modifications. Those modifications are compatible with solid-phase synthesis and stable during Te-oligonucleotide purification. Moreover, the ideal electronic and atomic properties of tellurium for generating clear isomorphous signals give Te-modified DNA and RNA great potential applications in 3D crystal structure determination through X-ray diffraction. STM study also shows that Te-modified DNA has strong topographic and current peaks, which immediately suggests potential applications in nucleic acid direct imaging, nanomaterials, molecular electronics, and diagnostics. Theoretical studies indicate the potential application of Te-modified nucleosides in cancer therapy. MDPI 2022-12-01 /pmc/articles/PMC9737395/ /pubmed/36500495 http://dx.doi.org/10.3390/molecules27238379 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Chen, Cen
Huang, Zhen
Tellurium-Modified Nucleosides, Nucleotides, and Nucleic Acids with Potential Applications
title Tellurium-Modified Nucleosides, Nucleotides, and Nucleic Acids with Potential Applications
title_full Tellurium-Modified Nucleosides, Nucleotides, and Nucleic Acids with Potential Applications
title_fullStr Tellurium-Modified Nucleosides, Nucleotides, and Nucleic Acids with Potential Applications
title_full_unstemmed Tellurium-Modified Nucleosides, Nucleotides, and Nucleic Acids with Potential Applications
title_short Tellurium-Modified Nucleosides, Nucleotides, and Nucleic Acids with Potential Applications
title_sort tellurium-modified nucleosides, nucleotides, and nucleic acids with potential applications
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737395/
https://www.ncbi.nlm.nih.gov/pubmed/36500495
http://dx.doi.org/10.3390/molecules27238379
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