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Enhanced Acetaminophen Electrochemical Sensing Based on Nitrogen-Doped Graphene
Because of the widespread acetaminophen usage and the danger of harmful overdosing effects, developing appropriate procedures for its quantitative and qualitative assay has always been an intriguing and fascinating problem. A quick, inexpensive, and environmentally friendly approach based on direct...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737486/ https://www.ncbi.nlm.nih.gov/pubmed/36499193 http://dx.doi.org/10.3390/ijms232314866 |
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author | Magerusan, Lidia Pogacean, Florina Pruneanu, Stela |
author_facet | Magerusan, Lidia Pogacean, Florina Pruneanu, Stela |
author_sort | Magerusan, Lidia |
collection | PubMed |
description | Because of the widespread acetaminophen usage and the danger of harmful overdosing effects, developing appropriate procedures for its quantitative and qualitative assay has always been an intriguing and fascinating problem. A quick, inexpensive, and environmentally friendly approach based on direct voltage anodic graphite rod exfoliation in the presence of inorganic salt aqueous solution ((NH(4))(2)SO(4)–0.3 M) has been established for the preparation of nitrogen-doped graphene (exf-NGr). The XRD analysis shows that the working material appears as a mixture of few (76.43%) and multi-layers (23.57%) of N-doped graphenes. From XPS, the C/O ratio was calculated to be 0.39, indicating a significant number of structural defects and the existence of multiple oxygen-containing groups at the surface of graphene sheets caused by heteroatom doping. Furthermore, the electrochemical performances of glassy carbon electrodes (GCEs) modified with exf-NGr for acetaminophen (AMP) detection and quantification have been assessed. The exf-NGr/GCE-modified electrode shows excellent reproducibility, stability, and anti-interfering characteristics with improved electrocatalytic activity over a wide detection range (0.1–100 µM), with a low limit for AMP detection (LOD = 3.03 nM). In addition, the developed sensor has been successfully applied in real sample analysis for the AMP quantification from different commercially available pharmaceutical formulations. |
format | Online Article Text |
id | pubmed-9737486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97374862022-12-11 Enhanced Acetaminophen Electrochemical Sensing Based on Nitrogen-Doped Graphene Magerusan, Lidia Pogacean, Florina Pruneanu, Stela Int J Mol Sci Article Because of the widespread acetaminophen usage and the danger of harmful overdosing effects, developing appropriate procedures for its quantitative and qualitative assay has always been an intriguing and fascinating problem. A quick, inexpensive, and environmentally friendly approach based on direct voltage anodic graphite rod exfoliation in the presence of inorganic salt aqueous solution ((NH(4))(2)SO(4)–0.3 M) has been established for the preparation of nitrogen-doped graphene (exf-NGr). The XRD analysis shows that the working material appears as a mixture of few (76.43%) and multi-layers (23.57%) of N-doped graphenes. From XPS, the C/O ratio was calculated to be 0.39, indicating a significant number of structural defects and the existence of multiple oxygen-containing groups at the surface of graphene sheets caused by heteroatom doping. Furthermore, the electrochemical performances of glassy carbon electrodes (GCEs) modified with exf-NGr for acetaminophen (AMP) detection and quantification have been assessed. The exf-NGr/GCE-modified electrode shows excellent reproducibility, stability, and anti-interfering characteristics with improved electrocatalytic activity over a wide detection range (0.1–100 µM), with a low limit for AMP detection (LOD = 3.03 nM). In addition, the developed sensor has been successfully applied in real sample analysis for the AMP quantification from different commercially available pharmaceutical formulations. MDPI 2022-11-28 /pmc/articles/PMC9737486/ /pubmed/36499193 http://dx.doi.org/10.3390/ijms232314866 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Magerusan, Lidia Pogacean, Florina Pruneanu, Stela Enhanced Acetaminophen Electrochemical Sensing Based on Nitrogen-Doped Graphene |
title | Enhanced Acetaminophen Electrochemical Sensing Based on Nitrogen-Doped Graphene |
title_full | Enhanced Acetaminophen Electrochemical Sensing Based on Nitrogen-Doped Graphene |
title_fullStr | Enhanced Acetaminophen Electrochemical Sensing Based on Nitrogen-Doped Graphene |
title_full_unstemmed | Enhanced Acetaminophen Electrochemical Sensing Based on Nitrogen-Doped Graphene |
title_short | Enhanced Acetaminophen Electrochemical Sensing Based on Nitrogen-Doped Graphene |
title_sort | enhanced acetaminophen electrochemical sensing based on nitrogen-doped graphene |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737486/ https://www.ncbi.nlm.nih.gov/pubmed/36499193 http://dx.doi.org/10.3390/ijms232314866 |
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