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Microorganisms—An Effective Tool to Intensify the Utilization of Sulforaphane

Sulforaphane (SFN) was generated by the hydrolysis of glucoraphanin under the action of myrosinase. However, due to the instability of SFN, the bioavailability of SFN was limited. Meanwhile, the gut flora obtained the ability to synthesize myrosinase and glucoraphanin, which could be converted into...

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Detalles Bibliográficos
Autores principales: Li, Xiude, Wang, Yihan, Zhao, Guoping, Liu, Guangmin, Wang, Pengjie, Li, Jinwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737538/
https://www.ncbi.nlm.nih.gov/pubmed/36496582
http://dx.doi.org/10.3390/foods11233775
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author Li, Xiude
Wang, Yihan
Zhao, Guoping
Liu, Guangmin
Wang, Pengjie
Li, Jinwang
author_facet Li, Xiude
Wang, Yihan
Zhao, Guoping
Liu, Guangmin
Wang, Pengjie
Li, Jinwang
author_sort Li, Xiude
collection PubMed
description Sulforaphane (SFN) was generated by the hydrolysis of glucoraphanin under the action of myrosinase. However, due to the instability of SFN, the bioavailability of SFN was limited. Meanwhile, the gut flora obtained the ability to synthesize myrosinase and glucoraphanin, which could be converted into SFN in the intestine. However, the ability of microorganisms to synthesize myrosinase in the gut was limited. Therefore, microorganisms with myrosinase synthesis ability need to be supplemented. With the development of research, microorganisms with high levels of myrosinase synthesis could be obtained by artificial selection and gene modification. Researchers found the SFN production rate of the transformed microorganisms could be significantly improved. However, despite applying transformation technology and regulating nutrients to microorganisms, it still could not provide the best efficiency during generating SFN and could not accomplish colonization in the intestine. Due to the great effect of microencapsulation on improving the colonization ability of microorganisms, microencapsulation is currently an important way to deliver microorganisms into the gut. This article mainly analyzed the possibility of obtaining SFN-producing microorganisms through gene modification and delivering them to the gut via microencapsulation to improve the utilization rate of SFN. It could provide a theoretical basis for expanding the application scope of SFN.
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spelling pubmed-97375382022-12-11 Microorganisms—An Effective Tool to Intensify the Utilization of Sulforaphane Li, Xiude Wang, Yihan Zhao, Guoping Liu, Guangmin Wang, Pengjie Li, Jinwang Foods Review Sulforaphane (SFN) was generated by the hydrolysis of glucoraphanin under the action of myrosinase. However, due to the instability of SFN, the bioavailability of SFN was limited. Meanwhile, the gut flora obtained the ability to synthesize myrosinase and glucoraphanin, which could be converted into SFN in the intestine. However, the ability of microorganisms to synthesize myrosinase in the gut was limited. Therefore, microorganisms with myrosinase synthesis ability need to be supplemented. With the development of research, microorganisms with high levels of myrosinase synthesis could be obtained by artificial selection and gene modification. Researchers found the SFN production rate of the transformed microorganisms could be significantly improved. However, despite applying transformation technology and regulating nutrients to microorganisms, it still could not provide the best efficiency during generating SFN and could not accomplish colonization in the intestine. Due to the great effect of microencapsulation on improving the colonization ability of microorganisms, microencapsulation is currently an important way to deliver microorganisms into the gut. This article mainly analyzed the possibility of obtaining SFN-producing microorganisms through gene modification and delivering them to the gut via microencapsulation to improve the utilization rate of SFN. It could provide a theoretical basis for expanding the application scope of SFN. MDPI 2022-11-23 /pmc/articles/PMC9737538/ /pubmed/36496582 http://dx.doi.org/10.3390/foods11233775 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Xiude
Wang, Yihan
Zhao, Guoping
Liu, Guangmin
Wang, Pengjie
Li, Jinwang
Microorganisms—An Effective Tool to Intensify the Utilization of Sulforaphane
title Microorganisms—An Effective Tool to Intensify the Utilization of Sulforaphane
title_full Microorganisms—An Effective Tool to Intensify the Utilization of Sulforaphane
title_fullStr Microorganisms—An Effective Tool to Intensify the Utilization of Sulforaphane
title_full_unstemmed Microorganisms—An Effective Tool to Intensify the Utilization of Sulforaphane
title_short Microorganisms—An Effective Tool to Intensify the Utilization of Sulforaphane
title_sort microorganisms—an effective tool to intensify the utilization of sulforaphane
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737538/
https://www.ncbi.nlm.nih.gov/pubmed/36496582
http://dx.doi.org/10.3390/foods11233775
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