Cargando…
Non-Invasive Tear Break-Up Detection with the Kowa DR-1α and Its Relationship to Dry Eye Clinical Severity
The purpose of this study is to compare visual versus software detection of non-invasive tear break-up with the KOWA DR-1α tear interferometer and investigate the relationship between non-invasive tear break-up time (NIBUT) and dry eye clinical severity. Tear interferometry with the KOWA DR-1α, toge...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737539/ https://www.ncbi.nlm.nih.gov/pubmed/36499103 http://dx.doi.org/10.3390/ijms232314774 |
_version_ | 1784847315143491584 |
---|---|
author | Pflugfelder, Stephen Nakhleh, Lauren Kikukawa, Yasushi Tanaka, Shin Kosugi, Takuya |
author_facet | Pflugfelder, Stephen Nakhleh, Lauren Kikukawa, Yasushi Tanaka, Shin Kosugi, Takuya |
author_sort | Pflugfelder, Stephen |
collection | PubMed |
description | The purpose of this study is to compare visual versus software detection of non-invasive tear break-up with the KOWA DR-1α tear interferometer and investigate the relationship between non-invasive tear break-up time (NIBUT) and dry eye clinical severity. Tear interferometry with the KOWA DR-1α, together with a standardized comprehensive ocular surface/tear evaluation, was performed on 348 consecutive eyes. Investigator visually detected or software detected non-invasive tear break-up and NIBUT were measured and compared on a subset of these examinations. The relationship between software-detected NIBUT and categorical dry eye severity based on irritation symptoms and corneal and conjunctival dye staining scores was determined. The sensitivity of visual (frame-by-frame) or software detected non-invasive tear break-up in eyes with tear instability (FBUT < 10) was similar (range 63–69%). NIBUT, measured visually or by software, had a correlation coefficient of 0.87. NIBUT was significantly lower in severity levels 2 and 3 compared to levels 0 + 1, and level 3 was significantly lower than level 2. In conclusion, there is a good correlation between investigator visually detected and software-detected tear break-up and tear break-up time in the KOWA DR-1α interferometric fringe images. Software-detected NIBUT is a clinically relevant measure of dry eye clinical severity. |
format | Online Article Text |
id | pubmed-9737539 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97375392022-12-11 Non-Invasive Tear Break-Up Detection with the Kowa DR-1α and Its Relationship to Dry Eye Clinical Severity Pflugfelder, Stephen Nakhleh, Lauren Kikukawa, Yasushi Tanaka, Shin Kosugi, Takuya Int J Mol Sci Article The purpose of this study is to compare visual versus software detection of non-invasive tear break-up with the KOWA DR-1α tear interferometer and investigate the relationship between non-invasive tear break-up time (NIBUT) and dry eye clinical severity. Tear interferometry with the KOWA DR-1α, together with a standardized comprehensive ocular surface/tear evaluation, was performed on 348 consecutive eyes. Investigator visually detected or software detected non-invasive tear break-up and NIBUT were measured and compared on a subset of these examinations. The relationship between software-detected NIBUT and categorical dry eye severity based on irritation symptoms and corneal and conjunctival dye staining scores was determined. The sensitivity of visual (frame-by-frame) or software detected non-invasive tear break-up in eyes with tear instability (FBUT < 10) was similar (range 63–69%). NIBUT, measured visually or by software, had a correlation coefficient of 0.87. NIBUT was significantly lower in severity levels 2 and 3 compared to levels 0 + 1, and level 3 was significantly lower than level 2. In conclusion, there is a good correlation between investigator visually detected and software-detected tear break-up and tear break-up time in the KOWA DR-1α interferometric fringe images. Software-detected NIBUT is a clinically relevant measure of dry eye clinical severity. MDPI 2022-11-25 /pmc/articles/PMC9737539/ /pubmed/36499103 http://dx.doi.org/10.3390/ijms232314774 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pflugfelder, Stephen Nakhleh, Lauren Kikukawa, Yasushi Tanaka, Shin Kosugi, Takuya Non-Invasive Tear Break-Up Detection with the Kowa DR-1α and Its Relationship to Dry Eye Clinical Severity |
title | Non-Invasive Tear Break-Up Detection with the Kowa DR-1α and Its Relationship to Dry Eye Clinical Severity |
title_full | Non-Invasive Tear Break-Up Detection with the Kowa DR-1α and Its Relationship to Dry Eye Clinical Severity |
title_fullStr | Non-Invasive Tear Break-Up Detection with the Kowa DR-1α and Its Relationship to Dry Eye Clinical Severity |
title_full_unstemmed | Non-Invasive Tear Break-Up Detection with the Kowa DR-1α and Its Relationship to Dry Eye Clinical Severity |
title_short | Non-Invasive Tear Break-Up Detection with the Kowa DR-1α and Its Relationship to Dry Eye Clinical Severity |
title_sort | non-invasive tear break-up detection with the kowa dr-1α and its relationship to dry eye clinical severity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737539/ https://www.ncbi.nlm.nih.gov/pubmed/36499103 http://dx.doi.org/10.3390/ijms232314774 |
work_keys_str_mv | AT pflugfelderstephen noninvasivetearbreakupdetectionwiththekowadr1aanditsrelationshiptodryeyeclinicalseverity AT nakhlehlauren noninvasivetearbreakupdetectionwiththekowadr1aanditsrelationshiptodryeyeclinicalseverity AT kikukawayasushi noninvasivetearbreakupdetectionwiththekowadr1aanditsrelationshiptodryeyeclinicalseverity AT tanakashin noninvasivetearbreakupdetectionwiththekowadr1aanditsrelationshiptodryeyeclinicalseverity AT kosugitakuya noninvasivetearbreakupdetectionwiththekowadr1aanditsrelationshiptodryeyeclinicalseverity |