Impact of FLT3–ITD Mutation Status and Its Ratio in a Cohort of 2901 Patients Undergoing Upfront Intensive Chemotherapy: A PETHEMA Registry Study

SIMPLE SUMMARY: The prognostic impact of FLT3–ITD allele ratio (AR) is a matter of controversy. We analyzed 2901 AML patients with long-term follow-up treated with PETHEMA protocols in the pre-FLT3 inhibitors era, with 579 of them harboring the FLT3–ITD mutation. We found that FLT3–ITD AR > 0.5 w...

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Detalles Bibliográficos
Autores principales: Ayala, Rosa, Carreño-Tarragona, Gonzalo, Barragán, Eva, Boluda, Blanca, Larráyoz, María J., Chillón, María Carmen, Carrillo-Cruz, Estrella, Bilbao, Cristina, Sánchez-García, Joaquín, Bernal, Teresa, Martinez-Cuadron, David, Gil, Cristina, Serrano, Josefina, Rodriguez-Medina, Carlos, Bergua, Juan, Pérez-Simón, José A., Calbacho, María, Alonso-Domínguez, Juan M., Labrador, Jorge, Tormo, Mar, Amigo, Maria Luz, Herrera-Puente, Pilar, Rapado, Inmaculada, Sargas, Claudia, Vazquez, Iria, Calasanz, María J., Gomez-Casares, Teresa, García-Sanz, Ramón, Sanz, Miguel A., Martínez-López, Joaquín, Montesinos, Pau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737662/
https://www.ncbi.nlm.nih.gov/pubmed/36497281
http://dx.doi.org/10.3390/cancers14235799

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