Cargando…

Estimating the Mass of Food Components Necessary for the Utilization of Free Radical Particles in the Human Body

The article proposes an algorithm for an approximate assessment of the molar volume of free radicals generated in the human body per day. It takes into account the act of breathing, physical activity, food consumption, the influence of unfavorable environmental conditions, exposure to xenobiotics, a...

Descripción completa

Detalles Bibliográficos
Autores principales: Gorbachev, Victor, Nikulchev, Evgeny, Kosenkov, Alexander N., Sokolov, Andrey, Zavalishin, Igor, Nikitin, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737927/
https://www.ncbi.nlm.nih.gov/pubmed/36497648
http://dx.doi.org/10.3390/ijerph192315574
_version_ 1784847410793545728
author Gorbachev, Victor
Nikulchev, Evgeny
Kosenkov, Alexander N.
Sokolov, Andrey
Zavalishin, Igor
Nikitin, Igor
author_facet Gorbachev, Victor
Nikulchev, Evgeny
Kosenkov, Alexander N.
Sokolov, Andrey
Zavalishin, Igor
Nikitin, Igor
author_sort Gorbachev, Victor
collection PubMed
description The article proposes an algorithm for an approximate assessment of the molar volume of free radicals generated in the human body per day. It takes into account the act of breathing, physical activity, food consumption, the influence of unfavorable environmental conditions, exposure to xenobiotics, as well as bad habits (alcohol and tobacco smoking). A calculation of the required set of the most commonly used food products for the disposal of free radicals was made. The calculation is a structure of four blocks with the possibility of adding optional data from human population genetic studies, environmental conditions, etc. In the proposed algorithm, the results of antiradical activity (ARA) of food products are used as input, including the results of predicting antiradical activity using artificial neural networks (ANN), which we published earlier. Based on the accepted values of one equivalent (in terms of the activity of 1 μmol of ascorbic acid), it was shown (for our data) that for the utilization of all free radicals produced in the human body per day, it will take an average of ≈260 to ≈540 g of food components in terms of dry mass (including proteins, fats, carbohydrates, etc.). At the same time, for the utilization of consumed xenobiotics, from 220 mg (in terms of vitamin C) to 260 mg (in terms of acetylcysteine -NAC) of additional plastic components or 11.5–13.0 g of essential amino acids will be required, which must be taken into account when calculating diets. This approach will be useful in the development of new functional foods, as well as in assessing the possible impact of diets on human health. Another applied point of this study is related to the possibility of using these data for better detailing and selection of food products for people working in conditions of increased radiation (in space conditions), in contact with harmful substances (chemical synthesis and production), for people practicing increased physical activity (bodybuilding and sports), and for the purposes of medical nutritional therapy.
format Online
Article
Text
id pubmed-9737927
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97379272022-12-11 Estimating the Mass of Food Components Necessary for the Utilization of Free Radical Particles in the Human Body Gorbachev, Victor Nikulchev, Evgeny Kosenkov, Alexander N. Sokolov, Andrey Zavalishin, Igor Nikitin, Igor Int J Environ Res Public Health Article The article proposes an algorithm for an approximate assessment of the molar volume of free radicals generated in the human body per day. It takes into account the act of breathing, physical activity, food consumption, the influence of unfavorable environmental conditions, exposure to xenobiotics, as well as bad habits (alcohol and tobacco smoking). A calculation of the required set of the most commonly used food products for the disposal of free radicals was made. The calculation is a structure of four blocks with the possibility of adding optional data from human population genetic studies, environmental conditions, etc. In the proposed algorithm, the results of antiradical activity (ARA) of food products are used as input, including the results of predicting antiradical activity using artificial neural networks (ANN), which we published earlier. Based on the accepted values of one equivalent (in terms of the activity of 1 μmol of ascorbic acid), it was shown (for our data) that for the utilization of all free radicals produced in the human body per day, it will take an average of ≈260 to ≈540 g of food components in terms of dry mass (including proteins, fats, carbohydrates, etc.). At the same time, for the utilization of consumed xenobiotics, from 220 mg (in terms of vitamin C) to 260 mg (in terms of acetylcysteine -NAC) of additional plastic components or 11.5–13.0 g of essential amino acids will be required, which must be taken into account when calculating diets. This approach will be useful in the development of new functional foods, as well as in assessing the possible impact of diets on human health. Another applied point of this study is related to the possibility of using these data for better detailing and selection of food products for people working in conditions of increased radiation (in space conditions), in contact with harmful substances (chemical synthesis and production), for people practicing increased physical activity (bodybuilding and sports), and for the purposes of medical nutritional therapy. MDPI 2022-11-23 /pmc/articles/PMC9737927/ /pubmed/36497648 http://dx.doi.org/10.3390/ijerph192315574 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gorbachev, Victor
Nikulchev, Evgeny
Kosenkov, Alexander N.
Sokolov, Andrey
Zavalishin, Igor
Nikitin, Igor
Estimating the Mass of Food Components Necessary for the Utilization of Free Radical Particles in the Human Body
title Estimating the Mass of Food Components Necessary for the Utilization of Free Radical Particles in the Human Body
title_full Estimating the Mass of Food Components Necessary for the Utilization of Free Radical Particles in the Human Body
title_fullStr Estimating the Mass of Food Components Necessary for the Utilization of Free Radical Particles in the Human Body
title_full_unstemmed Estimating the Mass of Food Components Necessary for the Utilization of Free Radical Particles in the Human Body
title_short Estimating the Mass of Food Components Necessary for the Utilization of Free Radical Particles in the Human Body
title_sort estimating the mass of food components necessary for the utilization of free radical particles in the human body
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737927/
https://www.ncbi.nlm.nih.gov/pubmed/36497648
http://dx.doi.org/10.3390/ijerph192315574
work_keys_str_mv AT gorbachevvictor estimatingthemassoffoodcomponentsnecessaryfortheutilizationoffreeradicalparticlesinthehumanbody
AT nikulchevevgeny estimatingthemassoffoodcomponentsnecessaryfortheutilizationoffreeradicalparticlesinthehumanbody
AT kosenkovalexandern estimatingthemassoffoodcomponentsnecessaryfortheutilizationoffreeradicalparticlesinthehumanbody
AT sokolovandrey estimatingthemassoffoodcomponentsnecessaryfortheutilizationoffreeradicalparticlesinthehumanbody
AT zavalishinigor estimatingthemassoffoodcomponentsnecessaryfortheutilizationoffreeradicalparticlesinthehumanbody
AT nikitinigor estimatingthemassoffoodcomponentsnecessaryfortheutilizationoffreeradicalparticlesinthehumanbody