Cargando…

Dual LSD1 and HDAC6 Inhibition Induces Doxorubicin Sensitivity in Acute Myeloid Leukemia Cells

SIMPLE SUMMARY: GSK2879552 is a LSD1 inhibitor in clinical development. By structural modification, we obtained an analogue that is a potent and selective dual inhibitor of HDAC6 and LSD1 (IC(50) 110 and 540 nM, respectively). The dual targeting agent was superior to GSK2879552 in the growth inhibit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bulut, Ipek, Lee, Adam, Cevatemre, Buse, Ruzic, Dusan, Belle, Roman, Kawamura, Akane, Gul, Sheraz, Nikolic, Katarina, Ganesan, A., Acilan, Ceyda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737972/ https://www.ncbi.nlm.nih.gov/pubmed/36497494 http://dx.doi.org/10.3390/cancers14236014

Ejemplares similares

Pyruvate Dehydrogenase Contributes to Drug Resistance of Lung Cancer Cells Through Epithelial Mesenchymal Transition
por: Cevatemre, Buse, et al.
Publicado: (2022)

Validation data supporting the characterization of novel copper complexes as anticancer agents
por: Acilan, Ceyda, et al.
Publicado: (2016)

Discovery of 1-Benzhydryl-Piperazine-Based HDAC Inhibitors with Anti-Breast Cancer Activity: Synthesis, Molecular Modeling, In Vitro and In Vivo Biological Evaluation
por: Ruzic, Dusan, et al.
Publicado: (2022)

Correlating Basal Gene Expression across Chemical Sensitivity Data to Screen for Novel Synergistic Interactors of HDAC Inhibitors in Pancreatic Carcinoma
por: Djokovic, Nemanja, et al.
Publicado: (2023)

Understanding the Potential In Vitro Modes of Action of Bis(β‐diketonato) Oxovanadium(IV) Complexes
por: Sergi, Baris, et al.
Publicado: (2021)

Novel dual LSD1/HDAC6 inhibitor for the treatment of cancer
por: Gajendran, Chandru, et al.
Publicado: (2023)

In silico Methods for Design of Kinase Inhibitors as Anticancer Drugs
por: Gagic, Zarko, et al.
Publicado: (2020)

Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties
por: Matos, Cristina P., et al.
Publicado: (2019)

Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells
por: Haydn, Tinka, et al.
Publicado: (2017)

Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex
por: Song, Yun, et al.
Publicado: (2020)

LSD1 inhibition modulates transcription factor networks in myeloid malignancies
por: Hartung, Emily E., et al.
Publicado: (2023)

HDAC1‐mediated deacetylation of LSD1 regulates vascular calcification by promoting autophagy in chronic renal failure
por: Zhou, Jiajun, et al.
Publicado: (2020)

DIPG-26. Targeted Protein Degradation of LSD1 synergizes with HDAC inhibitors in Diffuse Intrinsic Pontine Glioma
por: Groves, Andrew, et al.
Publicado: (2022)

Promising anticancer agents based on 8-hydroxyquinoline hydrazone copper(II) complexes
por: Ribeiro, Nádia, et al.
Publicado: (2023)

Targeting Histone Deacetylases: Opportunities for Cancer Treatment and Chemoprevention
por: Ruzic, Dusan, et al.
Publicado: (2022)

HDAC Inhibitors in Acute Myeloid Leukemia
por: San José-Enériz, Edurne, et al.
Publicado: (2019)

C-Abl is not actıvated in DNA damage-induced and Tap63-mediated oocyte apoptosıs in human ovary
por: Bildik, Gamze, et al.
Publicado: (2018)

Identification of LSD analogs, 1cP-AL-LAD, 1cP-MIPLA, 1V-LSD and LSZ in sheet products
por: Tanaka, Rie, et al.
Publicado: (2023)

The Role of LSD1 and LSD2 in Cancers of the Gastrointestinal System: An Update
por: Malagraba, Gianluca, et al.
Publicado: (2022)

Targeting Histone Deacetylases 6 in Dual-Target Therapy of Cancer
por: Beljkas, Milan, et al.
Publicado: (2023)

Data for a proteomic analysis of p53-independent induction of apoptosis by bortezomib
por: Yerlikaya, Azmi, et al.
Publicado: (2014)

ZNF198 Stabilizes the LSD1–CoREST–HDAC1 Complex on Chromatin through Its MYM-Type Zinc Fingers
por: Gocke, Christian B., et al.
Publicado: (2008)

Decreased Expression of CoREST1 and CoREST2 Together with LSD1 and HDAC1/2 during Neuronal Differentiation
por: Sáez, Julián Esteban, et al.
Publicado: (2015)

Functional Interaction of Histone Deacetylase 5 (HDAC5) and Lysine-specific Demethylase 1 (LSD1) Promotes Breast Cancer Progression
por: Cao, Chunyu, et al.
Publicado: (2016)

CD13 promotes hepatocellular carcinogenesis and sorafenib resistance by activating HDAC5‐LSD1‐NF‐κB oncogenic signaling
por: Hu, Bo, et al.
Publicado: (2020)

DIPG-53. LSD1 DEGRADATION SYNERGIZES WITH HDAC INHIBITION IN PEDIATRIC H3K27M DIFFUSE MIDLINE GLIOMA
por: Haase, Rebecca, et al.
Publicado: (2023)

Synergistic effect of HDAC inhibitor Chidamide with Cladribine on cell cycle arrest and apoptosis by targeting HDAC2/c-Myc/RCC1 axis in acute myeloid leukemia
por: Gu, Siyu, et al.
Publicado: (2023)

Keep Calm and Carry on with Extra Centrosomes
por: Kalkan, Batuhan Mert, et al.
Publicado: (2022)

Pegylated liposomal doxorubicin for myeloid neoplasms
por: Zhang, Cheng, et al.
Publicado: (2019)

Correction: Decreased Expression of CoREST1 and CoREST2 Together with LSD1 and HDAC1/2 during Neuronal Differentiation
Publicado: (2015)

The dual role of LSD1 and HDAC3 in STAT5-dependent transcription is determined by protein interactions, binding affinities, motifs and genomic positions
por: Nanou, Aikaterini, et al.
Publicado: (2017)

Small molecule inhibition of lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) alone and in combination in Ewing sarcoma cell lines
por: Welch, Darcy, et al.
Publicado: (2019)

Pilocarpine-induced seizures associate with modifications of LSD1/CoREST/HDAC1/2 epigenetic complex and repressive chromatin in mice hippocampus
por: Noches, Verónica, et al.
Publicado: (2020)

Tuning mTORC1 activity dictates the response of acute myeloid leukemia to LSD1 inhibition
por: Abdel-Aziz, Amal Kamal, et al.
Publicado: (2020)

Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1 oncogenic functions in AML
por: Nicosia, Luciano, et al.
Publicado: (2021)

LSD: individuo y sociedad
Publicado: (1970)

Modern Clinical Research on LSD
por: Liechti, Matthias E
Publicado: (2017)

Artificial hallucination: GPT on LSD?
por: Beutel, Gernot, et al.
Publicado: (2023)

High Level Constitutive Expression of Luciferase Reporter by lsd90 Promoter in Fission Yeast
por: Verma, Hemant Kumar, et al.
Publicado: (2014)

LSD : cómo descubrí el ácido y qué pasó después en el mundo
por: Hofmann, Albert
Publicado: (1997)

Cannot write session to /tmp/vufind_sessions/sess_lol4nmdinnuc4o5c9nlmmn2qgk