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Associations between migraine and major cardiovascular events in type 2 diabetes mellitus

BACKGROUND: Migraine is one of the most common primary headache disorders and a well-known risk factor for cardiovascular disorders. We aimed to investigate the association between migraine and major cardiovascular outcomes, including myocardial infarction (MI), ischemic stroke (IS), and cardiovascu...

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Autores principales: Cheon, Dae Young, Han, Kyungdo, Yang, Ye Seul, Kim, Yerim, Lee, Sang-Hwa, Kim, Chulho, Sohn, Jong-Hee, Oh, Mi Sun, Lee, Byung-Chul, Lee, Minwoo, Yu, Kyung-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737987/
https://www.ncbi.nlm.nih.gov/pubmed/36494651
http://dx.doi.org/10.1186/s12933-022-01705-3
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author Cheon, Dae Young
Han, Kyungdo
Yang, Ye Seul
Kim, Yerim
Lee, Sang-Hwa
Kim, Chulho
Sohn, Jong-Hee
Oh, Mi Sun
Lee, Byung-Chul
Lee, Minwoo
Yu, Kyung-Ho
author_facet Cheon, Dae Young
Han, Kyungdo
Yang, Ye Seul
Kim, Yerim
Lee, Sang-Hwa
Kim, Chulho
Sohn, Jong-Hee
Oh, Mi Sun
Lee, Byung-Chul
Lee, Minwoo
Yu, Kyung-Ho
author_sort Cheon, Dae Young
collection PubMed
description BACKGROUND: Migraine is one of the most common primary headache disorders and a well-known risk factor for cardiovascular disorders. We aimed to investigate the association between migraine and major cardiovascular outcomes, including myocardial infarction (MI), ischemic stroke (IS), and cardiovascular death (CVD) in people with type 2 diabetes. RESEARCH DESIGN AND METHODS: A total of 2,229,598 people from the nationwide Korean National Health Insurance Service database with type 2 diabetes but without a previous history of MI and IS were included in this study. We identified patients over 20 years of age with migraine using the claim data of International Statistical Classification of Diseases Related Health Problems, Tenth Revision (ICD-10) code G43. The patients with migraine were divided according to their migraine aura status. RESULTS: Migraine was present in 6.3% of the study population. Cases observed for MI, IS, CVD, and all-cause death were 2.6%, 3.6%, 5.9%, and 7.9%, respectively. The diagnosis of migraine was significantly associated with an increased risk of MI, IS, and CVD. The results remained significant after adjusting for covariates, including age, sex, body mass index, alcohol intake, smoking habits, physical activity, economic status, hypertension history, dyslipidemia, and duration of type 2 diabetes (MI, adjusted hazard ratio [aHR]: 1.182, 95% confidence interval [CI]: 1.146–1.219; IS, aHR: 1.111, 95% CI 1.082–1.14; CVD, aHR: 1.143, 95% CI 1.12–1.167). In particular, the presence of aura was associated with a higher risk of MI development compared to the non-aura group. The difference became more prominent with progressing age. CONCLUSIONS: In this nationwide population-based study, people with type 2 diabetes and migraines were found to be at a significantly higher risk for major cardiovascular events, including MI, IS, and CVD. The risk of MI and CVD significantly increased with the presence of aura symptoms among patients with migraine. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12933-022-01705-3.
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spelling pubmed-97379872022-12-11 Associations between migraine and major cardiovascular events in type 2 diabetes mellitus Cheon, Dae Young Han, Kyungdo Yang, Ye Seul Kim, Yerim Lee, Sang-Hwa Kim, Chulho Sohn, Jong-Hee Oh, Mi Sun Lee, Byung-Chul Lee, Minwoo Yu, Kyung-Ho Cardiovasc Diabetol Research BACKGROUND: Migraine is one of the most common primary headache disorders and a well-known risk factor for cardiovascular disorders. We aimed to investigate the association between migraine and major cardiovascular outcomes, including myocardial infarction (MI), ischemic stroke (IS), and cardiovascular death (CVD) in people with type 2 diabetes. RESEARCH DESIGN AND METHODS: A total of 2,229,598 people from the nationwide Korean National Health Insurance Service database with type 2 diabetes but without a previous history of MI and IS were included in this study. We identified patients over 20 years of age with migraine using the claim data of International Statistical Classification of Diseases Related Health Problems, Tenth Revision (ICD-10) code G43. The patients with migraine were divided according to their migraine aura status. RESULTS: Migraine was present in 6.3% of the study population. Cases observed for MI, IS, CVD, and all-cause death were 2.6%, 3.6%, 5.9%, and 7.9%, respectively. The diagnosis of migraine was significantly associated with an increased risk of MI, IS, and CVD. The results remained significant after adjusting for covariates, including age, sex, body mass index, alcohol intake, smoking habits, physical activity, economic status, hypertension history, dyslipidemia, and duration of type 2 diabetes (MI, adjusted hazard ratio [aHR]: 1.182, 95% confidence interval [CI]: 1.146–1.219; IS, aHR: 1.111, 95% CI 1.082–1.14; CVD, aHR: 1.143, 95% CI 1.12–1.167). In particular, the presence of aura was associated with a higher risk of MI development compared to the non-aura group. The difference became more prominent with progressing age. CONCLUSIONS: In this nationwide population-based study, people with type 2 diabetes and migraines were found to be at a significantly higher risk for major cardiovascular events, including MI, IS, and CVD. The risk of MI and CVD significantly increased with the presence of aura symptoms among patients with migraine. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12933-022-01705-3. BioMed Central 2022-12-09 /pmc/articles/PMC9737987/ /pubmed/36494651 http://dx.doi.org/10.1186/s12933-022-01705-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Cheon, Dae Young
Han, Kyungdo
Yang, Ye Seul
Kim, Yerim
Lee, Sang-Hwa
Kim, Chulho
Sohn, Jong-Hee
Oh, Mi Sun
Lee, Byung-Chul
Lee, Minwoo
Yu, Kyung-Ho
Associations between migraine and major cardiovascular events in type 2 diabetes mellitus
title Associations between migraine and major cardiovascular events in type 2 diabetes mellitus
title_full Associations between migraine and major cardiovascular events in type 2 diabetes mellitus
title_fullStr Associations between migraine and major cardiovascular events in type 2 diabetes mellitus
title_full_unstemmed Associations between migraine and major cardiovascular events in type 2 diabetes mellitus
title_short Associations between migraine and major cardiovascular events in type 2 diabetes mellitus
title_sort associations between migraine and major cardiovascular events in type 2 diabetes mellitus
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737987/
https://www.ncbi.nlm.nih.gov/pubmed/36494651
http://dx.doi.org/10.1186/s12933-022-01705-3
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