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Factors Associated with 30-Day in-Hospital Mortality Among Patients Admitted with Severe Covid-19 in Mbarara Regional Referral Hospital
BACKGROUND: COVID-19 has created a burden on the healthcare system globally. Severe COVID-19 is linked with high hospital mortality. Data regarding 30-day in-hospital mortality and its factors has not been explored in southwestern Uganda. METHODS: We carried out a retrospective, single-center cohort...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738092/ https://www.ncbi.nlm.nih.gov/pubmed/36510588 http://dx.doi.org/10.2147/IDR.S379443 |
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author | Mutekanga, Andrew Nuwagira, Edwin Kumbakumba, Elias Nyaiteera, Victoria Asiimwe, Stephen Gasumuni, Medal Wandera, Nelson Natumanya, Robert Akena, Denis Senoga, Siraje Kyobe Kiwanuka, Joseph Kateregga, George Munyarugero, Emmanuel Abeya, Fardous Charles Obwoya, Paul Stephen Ttendo, Stephen Muhindo, Rose |
author_facet | Mutekanga, Andrew Nuwagira, Edwin Kumbakumba, Elias Nyaiteera, Victoria Asiimwe, Stephen Gasumuni, Medal Wandera, Nelson Natumanya, Robert Akena, Denis Senoga, Siraje Kyobe Kiwanuka, Joseph Kateregga, George Munyarugero, Emmanuel Abeya, Fardous Charles Obwoya, Paul Stephen Ttendo, Stephen Muhindo, Rose |
author_sort | Mutekanga, Andrew |
collection | PubMed |
description | BACKGROUND: COVID-19 has created a burden on the healthcare system globally. Severe COVID-19 is linked with high hospital mortality. Data regarding 30-day in-hospital mortality and its factors has not been explored in southwestern Uganda. METHODS: We carried out a retrospective, single-center cohort study, and included all in-patients with laboratory-confirmed, radiological, or clinical severe COVID-19 admitted between April 2020 and September 2021 at Mbarara Regional Referral Hospital (MRRH). Demographic, laboratory, treatment, and clinical outcome data were extracted from patients’ files. These data were described comparing survivors and non-survivors. We used logistic regression to explore the factors associated with 30-day in-hospital mortality. RESULTS: Of the 283 patients with severe COVID-19 admitted at MRRH COVID-19 unit, 58.1% were male. The mean age ± standard deviation (SD) was 61±17.4 years; there were no differences in mean age between survivors and non-survivors (59 ± 17.2 versus 64.4 ±17.3, respectively, p=0.24) The median length of hospital stay was 7 (IQR 3–10) days (non-survivors had a shorter median length of stay 5 (IQR 2–9) days compared to the survivors; 8 (IQR 5–11) days, p<0.001. The most frequent comorbidities were hypertension (30.5%) and diabetes mellitus (30%). The overall 30-day in-hospital mortality was 134 of 279 (48%) mortality rate of 47,350×10(5) with a standard error of 2.99%. The factors associated with 30-day in-hospital mortality were age: 65 years and above (aOR, 3.88; 95% CI, 1.24–11.70; P =0.020) a neutrophil to lymphocyte ratio above 5 (aOR, 4.83; 95% CI, 1.53–15.28; P =0.007) and oxygen requirement ≥15L/min (aOR, 15.80; 95% CI, 5.17–48.25; P <0.001). CONCLUSION: We found a high 30-day in-hospital mortality among patients with severe forms of COVID-19. The identified factors could help clinicians to identify patients with poor prognosis at an early stage of admission. |
format | Online Article Text |
id | pubmed-9738092 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-97380922022-12-11 Factors Associated with 30-Day in-Hospital Mortality Among Patients Admitted with Severe Covid-19 in Mbarara Regional Referral Hospital Mutekanga, Andrew Nuwagira, Edwin Kumbakumba, Elias Nyaiteera, Victoria Asiimwe, Stephen Gasumuni, Medal Wandera, Nelson Natumanya, Robert Akena, Denis Senoga, Siraje Kyobe Kiwanuka, Joseph Kateregga, George Munyarugero, Emmanuel Abeya, Fardous Charles Obwoya, Paul Stephen Ttendo, Stephen Muhindo, Rose Infect Drug Resist Original Research BACKGROUND: COVID-19 has created a burden on the healthcare system globally. Severe COVID-19 is linked with high hospital mortality. Data regarding 30-day in-hospital mortality and its factors has not been explored in southwestern Uganda. METHODS: We carried out a retrospective, single-center cohort study, and included all in-patients with laboratory-confirmed, radiological, or clinical severe COVID-19 admitted between April 2020 and September 2021 at Mbarara Regional Referral Hospital (MRRH). Demographic, laboratory, treatment, and clinical outcome data were extracted from patients’ files. These data were described comparing survivors and non-survivors. We used logistic regression to explore the factors associated with 30-day in-hospital mortality. RESULTS: Of the 283 patients with severe COVID-19 admitted at MRRH COVID-19 unit, 58.1% were male. The mean age ± standard deviation (SD) was 61±17.4 years; there were no differences in mean age between survivors and non-survivors (59 ± 17.2 versus 64.4 ±17.3, respectively, p=0.24) The median length of hospital stay was 7 (IQR 3–10) days (non-survivors had a shorter median length of stay 5 (IQR 2–9) days compared to the survivors; 8 (IQR 5–11) days, p<0.001. The most frequent comorbidities were hypertension (30.5%) and diabetes mellitus (30%). The overall 30-day in-hospital mortality was 134 of 279 (48%) mortality rate of 47,350×10(5) with a standard error of 2.99%. The factors associated with 30-day in-hospital mortality were age: 65 years and above (aOR, 3.88; 95% CI, 1.24–11.70; P =0.020) a neutrophil to lymphocyte ratio above 5 (aOR, 4.83; 95% CI, 1.53–15.28; P =0.007) and oxygen requirement ≥15L/min (aOR, 15.80; 95% CI, 5.17–48.25; P <0.001). CONCLUSION: We found a high 30-day in-hospital mortality among patients with severe forms of COVID-19. The identified factors could help clinicians to identify patients with poor prognosis at an early stage of admission. Dove 2022-12-06 /pmc/articles/PMC9738092/ /pubmed/36510588 http://dx.doi.org/10.2147/IDR.S379443 Text en © 2022 Mutekanga et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Mutekanga, Andrew Nuwagira, Edwin Kumbakumba, Elias Nyaiteera, Victoria Asiimwe, Stephen Gasumuni, Medal Wandera, Nelson Natumanya, Robert Akena, Denis Senoga, Siraje Kyobe Kiwanuka, Joseph Kateregga, George Munyarugero, Emmanuel Abeya, Fardous Charles Obwoya, Paul Stephen Ttendo, Stephen Muhindo, Rose Factors Associated with 30-Day in-Hospital Mortality Among Patients Admitted with Severe Covid-19 in Mbarara Regional Referral Hospital |
title | Factors Associated with 30-Day in-Hospital Mortality Among Patients Admitted with Severe Covid-19 in Mbarara Regional Referral Hospital |
title_full | Factors Associated with 30-Day in-Hospital Mortality Among Patients Admitted with Severe Covid-19 in Mbarara Regional Referral Hospital |
title_fullStr | Factors Associated with 30-Day in-Hospital Mortality Among Patients Admitted with Severe Covid-19 in Mbarara Regional Referral Hospital |
title_full_unstemmed | Factors Associated with 30-Day in-Hospital Mortality Among Patients Admitted with Severe Covid-19 in Mbarara Regional Referral Hospital |
title_short | Factors Associated with 30-Day in-Hospital Mortality Among Patients Admitted with Severe Covid-19 in Mbarara Regional Referral Hospital |
title_sort | factors associated with 30-day in-hospital mortality among patients admitted with severe covid-19 in mbarara regional referral hospital |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738092/ https://www.ncbi.nlm.nih.gov/pubmed/36510588 http://dx.doi.org/10.2147/IDR.S379443 |
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