The Metabolic Role of Ketogenic Diets in Treating Epilepsy

Epilepsy is a long-term neurological condition that results in recurrent seizures. Approximately 30% of patients with epilepsy have drug-resistant epilepsy (DRE). The ketogenic diet (KD) is considered an effective alternative treatment for epileptic patients. The aim of this study was to identify th...

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Autores principales: Imdad, Kaleem, Abualait, Turki, Kanwal, Ammara, AlGhannam, Ziyad Tareq, Bashir, Shahab, Farrukh, Anum, Khattak, Sahir Hameed, Albaradie, Raidah, Bashir, Shahid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738161/
https://www.ncbi.nlm.nih.gov/pubmed/36501104
http://dx.doi.org/10.3390/nu14235074
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author Imdad, Kaleem
Abualait, Turki
Kanwal, Ammara
AlGhannam, Ziyad Tareq
Bashir, Shahab
Farrukh, Anum
Khattak, Sahir Hameed
Albaradie, Raidah
Bashir, Shahid
author_facet Imdad, Kaleem
Abualait, Turki
Kanwal, Ammara
AlGhannam, Ziyad Tareq
Bashir, Shahab
Farrukh, Anum
Khattak, Sahir Hameed
Albaradie, Raidah
Bashir, Shahid
author_sort Imdad, Kaleem
collection PubMed
description Epilepsy is a long-term neurological condition that results in recurrent seizures. Approximately 30% of patients with epilepsy have drug-resistant epilepsy (DRE). The ketogenic diet (KD) is considered an effective alternative treatment for epileptic patients. The aim of this study was to identify the metabolic role of the KD in epilepsy. Ketone bodies induce chemical messengers and alterations in neuronal metabolic activities to regulate neuroprotective mechanisms towards oxidative damage to decrease seizure rate. Here, we discuss the role of KD on epilepsy and related metabolic disorders, focusing on its mechanism of action, favorable effects, and limitations. We describe the significant role of the KD in managing epilepsy disorders.
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spelling pubmed-97381612022-12-11 The Metabolic Role of Ketogenic Diets in Treating Epilepsy Imdad, Kaleem Abualait, Turki Kanwal, Ammara AlGhannam, Ziyad Tareq Bashir, Shahab Farrukh, Anum Khattak, Sahir Hameed Albaradie, Raidah Bashir, Shahid Nutrients Review Epilepsy is a long-term neurological condition that results in recurrent seizures. Approximately 30% of patients with epilepsy have drug-resistant epilepsy (DRE). The ketogenic diet (KD) is considered an effective alternative treatment for epileptic patients. The aim of this study was to identify the metabolic role of the KD in epilepsy. Ketone bodies induce chemical messengers and alterations in neuronal metabolic activities to regulate neuroprotective mechanisms towards oxidative damage to decrease seizure rate. Here, we discuss the role of KD on epilepsy and related metabolic disorders, focusing on its mechanism of action, favorable effects, and limitations. We describe the significant role of the KD in managing epilepsy disorders. MDPI 2022-11-29 /pmc/articles/PMC9738161/ /pubmed/36501104 http://dx.doi.org/10.3390/nu14235074 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Imdad, Kaleem
Abualait, Turki
Kanwal, Ammara
AlGhannam, Ziyad Tareq
Bashir, Shahab
Farrukh, Anum
Khattak, Sahir Hameed
Albaradie, Raidah
Bashir, Shahid
The Metabolic Role of Ketogenic Diets in Treating Epilepsy
title The Metabolic Role of Ketogenic Diets in Treating Epilepsy
title_full The Metabolic Role of Ketogenic Diets in Treating Epilepsy
title_fullStr The Metabolic Role of Ketogenic Diets in Treating Epilepsy
title_full_unstemmed The Metabolic Role of Ketogenic Diets in Treating Epilepsy
title_short The Metabolic Role of Ketogenic Diets in Treating Epilepsy
title_sort metabolic role of ketogenic diets in treating epilepsy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738161/
https://www.ncbi.nlm.nih.gov/pubmed/36501104
http://dx.doi.org/10.3390/nu14235074
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