Empagliflozin and Dapagliflozin Increase Na(+) and Inward Rectifier K(+) Current Densities in Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells (hiPSC-CMs)

Dapagliflozin (dapa) and empagliflozin (empa) are sodium-glucose cotransporter-2 inhibitors (SGLT2is) that reduce morbidity and mortality in heart failure (HF) patients. Sodium and inward rectifier K(+) currents (I(Na) and I(K1)), carried by Nav1.5 and Kir2.1 channels, respectively, are responsible...

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Detalles Bibliográficos
Autores principales: Dago, María, Crespo-García, Teresa, Cámara-Checa, Anabel, Rapún, Josu, Rubio-Alarcón, Marcos, Marín, María, Tamargo, Juan, Caballero, Ricardo, Delpón, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738206/
https://www.ncbi.nlm.nih.gov/pubmed/36496967
http://dx.doi.org/10.3390/cells11233707

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