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Efficacy of the PRESERFLO MicroShunt and a Meta-Analysis of the Literature

Background: Recent studies on the PRESERFLO MicroShunt suggest that it may be effective in lowering intraocular pressure (IOP); however, the number of studies on this device remains limited. Therefore, we assessed the efficacy of the PRESERFLO MicroShunt in patients with glaucoma and performed a met...

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Autores principales: Pawiroredjo, Shigeo S. M., Bramer, Wichor M., Pawiroredjo, Noemi D., Pals, Jan, Poelman, Huub J., de Vries, Victor A., Wolfs, Roger C. W., Ramdas, Wishal D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738249/
https://www.ncbi.nlm.nih.gov/pubmed/36498729
http://dx.doi.org/10.3390/jcm11237149
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author Pawiroredjo, Shigeo S. M.
Bramer, Wichor M.
Pawiroredjo, Noemi D.
Pals, Jan
Poelman, Huub J.
de Vries, Victor A.
Wolfs, Roger C. W.
Ramdas, Wishal D.
author_facet Pawiroredjo, Shigeo S. M.
Bramer, Wichor M.
Pawiroredjo, Noemi D.
Pals, Jan
Poelman, Huub J.
de Vries, Victor A.
Wolfs, Roger C. W.
Ramdas, Wishal D.
author_sort Pawiroredjo, Shigeo S. M.
collection PubMed
description Background: Recent studies on the PRESERFLO MicroShunt suggest that it may be effective in lowering intraocular pressure (IOP); however, the number of studies on this device remains limited. Therefore, we assessed the efficacy of the PRESERFLO MicroShunt in patients with glaucoma and performed a meta-analysis of published results. Methods: Prospective study including all patients that underwent PRESERFLO MicroShunt surgery from 2018 onwards. Sub-analyses were performed for cataract-combined procedures. To compare our results, we performed a systematic review and meta-analysis. IOP, IOP-lowering medication and surgical complications reported in the retrieved studies were assessed. Results: A total of 72 eyes underwent PRESERFLO-implant surgery (59 as standalone procedure and 13 as cataract-combined procedure). No significant differences were found in IOP and IOP-lowering medication between both groups. The mean ± standard deviation IOP and IOP-lowering medications of both groups taken together declined from 21.72 ± 8.35 to 15.92 ± 8.54 mmHg (p < 0.001, 26.7% reduction) and 3.40 to 0.93 (p < 0.001, 72.6% reduction) at 1 year follow-up, respectively. Secondary surgeries were required in 19.4% of eyes, the majority (71.4%) within 6 months. The meta-analysis including 14 studies (totaling 1213 PRESERFLO MicroShunt surgeries) from the systematic review showed a mean preoperative IOP and IOP-lowering medication of 22.28 ± 5.38 and 2.97 ± 1.07, respectively. The three-years postoperative pooled mean was (weighted mean difference, 95% CI) 11.07 (10.27 [8.23–12.32], p < 0.001) mmHg and 0.91 (1.77 [1.26–2.28], p < 0.001) for IOP and IOP-lowering medication, respectively. The most common reported complication was hypotony (2–39%). Conclusion: The PRESERFLO MicroShunt is effective and safe in lowering IOP and the number of IOP-lowering medications.
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spelling pubmed-97382492022-12-11 Efficacy of the PRESERFLO MicroShunt and a Meta-Analysis of the Literature Pawiroredjo, Shigeo S. M. Bramer, Wichor M. Pawiroredjo, Noemi D. Pals, Jan Poelman, Huub J. de Vries, Victor A. Wolfs, Roger C. W. Ramdas, Wishal D. J Clin Med Article Background: Recent studies on the PRESERFLO MicroShunt suggest that it may be effective in lowering intraocular pressure (IOP); however, the number of studies on this device remains limited. Therefore, we assessed the efficacy of the PRESERFLO MicroShunt in patients with glaucoma and performed a meta-analysis of published results. Methods: Prospective study including all patients that underwent PRESERFLO MicroShunt surgery from 2018 onwards. Sub-analyses were performed for cataract-combined procedures. To compare our results, we performed a systematic review and meta-analysis. IOP, IOP-lowering medication and surgical complications reported in the retrieved studies were assessed. Results: A total of 72 eyes underwent PRESERFLO-implant surgery (59 as standalone procedure and 13 as cataract-combined procedure). No significant differences were found in IOP and IOP-lowering medication between both groups. The mean ± standard deviation IOP and IOP-lowering medications of both groups taken together declined from 21.72 ± 8.35 to 15.92 ± 8.54 mmHg (p < 0.001, 26.7% reduction) and 3.40 to 0.93 (p < 0.001, 72.6% reduction) at 1 year follow-up, respectively. Secondary surgeries were required in 19.4% of eyes, the majority (71.4%) within 6 months. The meta-analysis including 14 studies (totaling 1213 PRESERFLO MicroShunt surgeries) from the systematic review showed a mean preoperative IOP and IOP-lowering medication of 22.28 ± 5.38 and 2.97 ± 1.07, respectively. The three-years postoperative pooled mean was (weighted mean difference, 95% CI) 11.07 (10.27 [8.23–12.32], p < 0.001) mmHg and 0.91 (1.77 [1.26–2.28], p < 0.001) for IOP and IOP-lowering medication, respectively. The most common reported complication was hypotony (2–39%). Conclusion: The PRESERFLO MicroShunt is effective and safe in lowering IOP and the number of IOP-lowering medications. MDPI 2022-12-01 /pmc/articles/PMC9738249/ /pubmed/36498729 http://dx.doi.org/10.3390/jcm11237149 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pawiroredjo, Shigeo S. M.
Bramer, Wichor M.
Pawiroredjo, Noemi D.
Pals, Jan
Poelman, Huub J.
de Vries, Victor A.
Wolfs, Roger C. W.
Ramdas, Wishal D.
Efficacy of the PRESERFLO MicroShunt and a Meta-Analysis of the Literature
title Efficacy of the PRESERFLO MicroShunt and a Meta-Analysis of the Literature
title_full Efficacy of the PRESERFLO MicroShunt and a Meta-Analysis of the Literature
title_fullStr Efficacy of the PRESERFLO MicroShunt and a Meta-Analysis of the Literature
title_full_unstemmed Efficacy of the PRESERFLO MicroShunt and a Meta-Analysis of the Literature
title_short Efficacy of the PRESERFLO MicroShunt and a Meta-Analysis of the Literature
title_sort efficacy of the preserflo microshunt and a meta-analysis of the literature
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738249/
https://www.ncbi.nlm.nih.gov/pubmed/36498729
http://dx.doi.org/10.3390/jcm11237149
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