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Bone Metastasis of Breast Cancer: Molecular Mechanisms and Therapeutic Strategies
SIMPLE SUMMARY: In this review, we present knowledge of the molecular mechanisms and therapeutic strategies of bone metastasis of breast cancer, particularly the interaction between metastatic breast cancer cells and the bone microenvironment in promoting the development of bone metastasis in breast...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738274/ https://www.ncbi.nlm.nih.gov/pubmed/36497209 http://dx.doi.org/10.3390/cancers14235727 |
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author | Pang, Lulian Gan, Chen Xu, Jian Jia, Yingxue Chai, Jiaying Huang, Runze Li, Anlong Ge, Han Yu, Sheng Cheng, Huaidong |
author_facet | Pang, Lulian Gan, Chen Xu, Jian Jia, Yingxue Chai, Jiaying Huang, Runze Li, Anlong Ge, Han Yu, Sheng Cheng, Huaidong |
author_sort | Pang, Lulian |
collection | PubMed |
description | SIMPLE SUMMARY: In this review, we present knowledge of the molecular mechanisms and therapeutic strategies of bone metastasis of breast cancer, particularly the interaction between metastatic breast cancer cells and the bone microenvironment in promoting the development of bone metastasis in breast cancer patients, with the aim of improving the quality of life and prognosis of breast cancer patients and providing a reference for future research directions. ABSTRACT: Bone metastasis is a common complication of many types of advanced cancer, including breast cancer. Bone metastasis may cause severe pain, fractures, and hypercalcemia, rendering clinical management challenging and substantially reducing the quality of life and overall survival (OS) time of breast cancer patients. Studies have revealed that bone metastasis is related to interactions between tumor cells and the bone microenvironment, and involves complex molecular biological mechanisms, including colonization, osteolytic destruction, and an immunosuppressive bone microenvironment. Agents inhibiting bone metastasis (such as bisphosphate and denosumab) alleviate bone destruction and improve the quality of life of breast cancer patients with bone metastasis. However, the prognosis of these patients remains poor, and the specific biological mechanism of bone metastasis is incompletely understood. Additional basic and clinical studies are urgently needed, to further explore the mechanism of bone metastasis and develop new therapeutic drugs. This review presents a summary of the molecular mechanisms and therapeutic strategies of bone metastasis of breast cancer, aiming to improve the quality of life and prognosis of breast cancer patients and provide a reference for future research directions. |
format | Online Article Text |
id | pubmed-9738274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97382742022-12-11 Bone Metastasis of Breast Cancer: Molecular Mechanisms and Therapeutic Strategies Pang, Lulian Gan, Chen Xu, Jian Jia, Yingxue Chai, Jiaying Huang, Runze Li, Anlong Ge, Han Yu, Sheng Cheng, Huaidong Cancers (Basel) Review SIMPLE SUMMARY: In this review, we present knowledge of the molecular mechanisms and therapeutic strategies of bone metastasis of breast cancer, particularly the interaction between metastatic breast cancer cells and the bone microenvironment in promoting the development of bone metastasis in breast cancer patients, with the aim of improving the quality of life and prognosis of breast cancer patients and providing a reference for future research directions. ABSTRACT: Bone metastasis is a common complication of many types of advanced cancer, including breast cancer. Bone metastasis may cause severe pain, fractures, and hypercalcemia, rendering clinical management challenging and substantially reducing the quality of life and overall survival (OS) time of breast cancer patients. Studies have revealed that bone metastasis is related to interactions between tumor cells and the bone microenvironment, and involves complex molecular biological mechanisms, including colonization, osteolytic destruction, and an immunosuppressive bone microenvironment. Agents inhibiting bone metastasis (such as bisphosphate and denosumab) alleviate bone destruction and improve the quality of life of breast cancer patients with bone metastasis. However, the prognosis of these patients remains poor, and the specific biological mechanism of bone metastasis is incompletely understood. Additional basic and clinical studies are urgently needed, to further explore the mechanism of bone metastasis and develop new therapeutic drugs. This review presents a summary of the molecular mechanisms and therapeutic strategies of bone metastasis of breast cancer, aiming to improve the quality of life and prognosis of breast cancer patients and provide a reference for future research directions. MDPI 2022-11-22 /pmc/articles/PMC9738274/ /pubmed/36497209 http://dx.doi.org/10.3390/cancers14235727 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pang, Lulian Gan, Chen Xu, Jian Jia, Yingxue Chai, Jiaying Huang, Runze Li, Anlong Ge, Han Yu, Sheng Cheng, Huaidong Bone Metastasis of Breast Cancer: Molecular Mechanisms and Therapeutic Strategies |
title | Bone Metastasis of Breast Cancer: Molecular Mechanisms and Therapeutic Strategies |
title_full | Bone Metastasis of Breast Cancer: Molecular Mechanisms and Therapeutic Strategies |
title_fullStr | Bone Metastasis of Breast Cancer: Molecular Mechanisms and Therapeutic Strategies |
title_full_unstemmed | Bone Metastasis of Breast Cancer: Molecular Mechanisms and Therapeutic Strategies |
title_short | Bone Metastasis of Breast Cancer: Molecular Mechanisms and Therapeutic Strategies |
title_sort | bone metastasis of breast cancer: molecular mechanisms and therapeutic strategies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738274/ https://www.ncbi.nlm.nih.gov/pubmed/36497209 http://dx.doi.org/10.3390/cancers14235727 |
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