Cargando…

A Polyoxometalate-Encapsulated Metal–Organic Framework Nanoplatform for Synergistic Photothermal–Chemotherapy and Anti-Inflammation of Ovarian Cancer

Photothermal therapy (PTT), as a noninvasive and local treatment, has emerged as a promising anti-tumor strategy with minimal damage to normal tissue under spatiotemporally controllable irradiation. However, the necrosis of cancer cells during PTT will induce an inflammatory reaction, which may moti...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Diqing, Wang, Yuqi, Zhang, Xinyu, Lv, Qian, Ma, Guiqi, Gao, Yuan, Liu, Shuangqing, Wang, Chenyu, Li, Changzhong, Sun, Xiao, Wan, Jipeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738349/
https://www.ncbi.nlm.nih.gov/pubmed/36500444
http://dx.doi.org/10.3390/molecules27238350
_version_ 1784847519032803328
author Wang, Diqing
Wang, Yuqi
Zhang, Xinyu
Lv, Qian
Ma, Guiqi
Gao, Yuan
Liu, Shuangqing
Wang, Chenyu
Li, Changzhong
Sun, Xiao
Wan, Jipeng
author_facet Wang, Diqing
Wang, Yuqi
Zhang, Xinyu
Lv, Qian
Ma, Guiqi
Gao, Yuan
Liu, Shuangqing
Wang, Chenyu
Li, Changzhong
Sun, Xiao
Wan, Jipeng
author_sort Wang, Diqing
collection PubMed
description Photothermal therapy (PTT), as a noninvasive and local treatment, has emerged as a promising anti-tumor strategy with minimal damage to normal tissue under spatiotemporally controllable irradiation. However, the necrosis of cancer cells during PTT will induce an inflammatory reaction, which may motivate tumor regeneration and resistance to therapy. In this study, polyoxometalates and a chloroquine diphosphate (CQ) co-loaded metal–organic framework nanoplatform with hyaluronic acid coating was constructed for efficient ovarian cancer therapy and anti-inflammation. Our results demonstrated that this nanoplatform not only displayed considerable photothermal therapeutic capacity under 808 nm near-infrared laser, but also had an impressive anti-inflammatory capacity by scavenging reactive oxygen species in the tumor microenvironment. CQ with pH dependence was used for the deacidification of lysosomes and the inhibition of autophagy, cutting off a self-protection pathway induced by cell necrosis–autophagy, and achieving the synergistic treatment of tumors. Therefore, we combined the excellent properties of these materials to synthesize a nanoplatform and explored its therapeutic effects in various aspects. This work provides a promising novel prospect for PTT/anti-inflammation/anti-autophagy combinations for efficient ovarian cancer treatment through the fine tuning of material design.
format Online
Article
Text
id pubmed-9738349
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97383492022-12-11 A Polyoxometalate-Encapsulated Metal–Organic Framework Nanoplatform for Synergistic Photothermal–Chemotherapy and Anti-Inflammation of Ovarian Cancer Wang, Diqing Wang, Yuqi Zhang, Xinyu Lv, Qian Ma, Guiqi Gao, Yuan Liu, Shuangqing Wang, Chenyu Li, Changzhong Sun, Xiao Wan, Jipeng Molecules Article Photothermal therapy (PTT), as a noninvasive and local treatment, has emerged as a promising anti-tumor strategy with minimal damage to normal tissue under spatiotemporally controllable irradiation. However, the necrosis of cancer cells during PTT will induce an inflammatory reaction, which may motivate tumor regeneration and resistance to therapy. In this study, polyoxometalates and a chloroquine diphosphate (CQ) co-loaded metal–organic framework nanoplatform with hyaluronic acid coating was constructed for efficient ovarian cancer therapy and anti-inflammation. Our results demonstrated that this nanoplatform not only displayed considerable photothermal therapeutic capacity under 808 nm near-infrared laser, but also had an impressive anti-inflammatory capacity by scavenging reactive oxygen species in the tumor microenvironment. CQ with pH dependence was used for the deacidification of lysosomes and the inhibition of autophagy, cutting off a self-protection pathway induced by cell necrosis–autophagy, and achieving the synergistic treatment of tumors. Therefore, we combined the excellent properties of these materials to synthesize a nanoplatform and explored its therapeutic effects in various aspects. This work provides a promising novel prospect for PTT/anti-inflammation/anti-autophagy combinations for efficient ovarian cancer treatment through the fine tuning of material design. MDPI 2022-11-30 /pmc/articles/PMC9738349/ /pubmed/36500444 http://dx.doi.org/10.3390/molecules27238350 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Diqing
Wang, Yuqi
Zhang, Xinyu
Lv, Qian
Ma, Guiqi
Gao, Yuan
Liu, Shuangqing
Wang, Chenyu
Li, Changzhong
Sun, Xiao
Wan, Jipeng
A Polyoxometalate-Encapsulated Metal–Organic Framework Nanoplatform for Synergistic Photothermal–Chemotherapy and Anti-Inflammation of Ovarian Cancer
title A Polyoxometalate-Encapsulated Metal–Organic Framework Nanoplatform for Synergistic Photothermal–Chemotherapy and Anti-Inflammation of Ovarian Cancer
title_full A Polyoxometalate-Encapsulated Metal–Organic Framework Nanoplatform for Synergistic Photothermal–Chemotherapy and Anti-Inflammation of Ovarian Cancer
title_fullStr A Polyoxometalate-Encapsulated Metal–Organic Framework Nanoplatform for Synergistic Photothermal–Chemotherapy and Anti-Inflammation of Ovarian Cancer
title_full_unstemmed A Polyoxometalate-Encapsulated Metal–Organic Framework Nanoplatform for Synergistic Photothermal–Chemotherapy and Anti-Inflammation of Ovarian Cancer
title_short A Polyoxometalate-Encapsulated Metal–Organic Framework Nanoplatform for Synergistic Photothermal–Chemotherapy and Anti-Inflammation of Ovarian Cancer
title_sort polyoxometalate-encapsulated metal–organic framework nanoplatform for synergistic photothermal–chemotherapy and anti-inflammation of ovarian cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738349/
https://www.ncbi.nlm.nih.gov/pubmed/36500444
http://dx.doi.org/10.3390/molecules27238350
work_keys_str_mv AT wangdiqing apolyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer
AT wangyuqi apolyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer
AT zhangxinyu apolyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer
AT lvqian apolyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer
AT maguiqi apolyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer
AT gaoyuan apolyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer
AT liushuangqing apolyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer
AT wangchenyu apolyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer
AT lichangzhong apolyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer
AT sunxiao apolyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer
AT wanjipeng apolyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer
AT wangdiqing polyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer
AT wangyuqi polyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer
AT zhangxinyu polyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer
AT lvqian polyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer
AT maguiqi polyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer
AT gaoyuan polyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer
AT liushuangqing polyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer
AT wangchenyu polyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer
AT lichangzhong polyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer
AT sunxiao polyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer
AT wanjipeng polyoxometalateencapsulatedmetalorganicframeworknanoplatformforsynergisticphotothermalchemotherapyandantiinflammationofovariancancer