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Electrocardiographic Parameters Associated with Adverse Outcomes in Children with Cardiomyopathies
Cardiomyopathies have a low prevalence in children and thus may lead to malignant ventricular arrhythmias or the progression of heart failure, resulting in death. In adults, the QRS-T angle derived from ECG has been associated with adverse outcomes in patients with hypertrophic and dilated cardiomyo...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738383/ https://www.ncbi.nlm.nih.gov/pubmed/36498505 http://dx.doi.org/10.3390/jcm11236930 |
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author | Luczak-Wozniak, Katarzyna Obsznajczyk, Klaudia Niszczota, Cezary Werner, Bożena |
author_facet | Luczak-Wozniak, Katarzyna Obsznajczyk, Klaudia Niszczota, Cezary Werner, Bożena |
author_sort | Luczak-Wozniak, Katarzyna |
collection | PubMed |
description | Cardiomyopathies have a low prevalence in children and thus may lead to malignant ventricular arrhythmias or the progression of heart failure, resulting in death. In adults, the QRS-T angle derived from ECG has been associated with adverse outcomes in patients with hypertrophic and dilated cardiomyopathies. We aimed to assess the electrocardiographic parameters, including QRS-T angle, associated with adverse cardiac events in children with cardiomyopathies. Forty-two children with cardiomyopathies were included in this study: 19 with dilated cardiomyopathy, 17 with hypertrophic cardiomyopathy, and 6 with left ventricular non-compaction. Additionally, 19 control subjects were recruited. In terms of ECG parameters, the QRS-T angle was significantly greater among patients with adverse outcomes compared to patients without the end points of the study (133° vs. 65°, p < 0.001). On Kaplan–Meier survival curves, QRS-T angle > 120°, increased serum concentrations of NT-proBNP and troponin I levels as well as greater NYHA or Ross scale were associated with the greatest risk of unfavorable outcome. The QRS-T angle appears to be a valuable component of 12-lead ECG interpretation, and might be helpful in outlining patients with the greatest cardiovascular risk. Additionally, serum biomarkers such as NT-proBNP (p = 0.003) and troponin (p < 0.001) are useful in outlining patients with the worst survival. |
format | Online Article Text |
id | pubmed-9738383 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97383832022-12-11 Electrocardiographic Parameters Associated with Adverse Outcomes in Children with Cardiomyopathies Luczak-Wozniak, Katarzyna Obsznajczyk, Klaudia Niszczota, Cezary Werner, Bożena J Clin Med Article Cardiomyopathies have a low prevalence in children and thus may lead to malignant ventricular arrhythmias or the progression of heart failure, resulting in death. In adults, the QRS-T angle derived from ECG has been associated with adverse outcomes in patients with hypertrophic and dilated cardiomyopathies. We aimed to assess the electrocardiographic parameters, including QRS-T angle, associated with adverse cardiac events in children with cardiomyopathies. Forty-two children with cardiomyopathies were included in this study: 19 with dilated cardiomyopathy, 17 with hypertrophic cardiomyopathy, and 6 with left ventricular non-compaction. Additionally, 19 control subjects were recruited. In terms of ECG parameters, the QRS-T angle was significantly greater among patients with adverse outcomes compared to patients without the end points of the study (133° vs. 65°, p < 0.001). On Kaplan–Meier survival curves, QRS-T angle > 120°, increased serum concentrations of NT-proBNP and troponin I levels as well as greater NYHA or Ross scale were associated with the greatest risk of unfavorable outcome. The QRS-T angle appears to be a valuable component of 12-lead ECG interpretation, and might be helpful in outlining patients with the greatest cardiovascular risk. Additionally, serum biomarkers such as NT-proBNP (p = 0.003) and troponin (p < 0.001) are useful in outlining patients with the worst survival. MDPI 2022-11-24 /pmc/articles/PMC9738383/ /pubmed/36498505 http://dx.doi.org/10.3390/jcm11236930 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Luczak-Wozniak, Katarzyna Obsznajczyk, Klaudia Niszczota, Cezary Werner, Bożena Electrocardiographic Parameters Associated with Adverse Outcomes in Children with Cardiomyopathies |
title | Electrocardiographic Parameters Associated with Adverse Outcomes in Children with Cardiomyopathies |
title_full | Electrocardiographic Parameters Associated with Adverse Outcomes in Children with Cardiomyopathies |
title_fullStr | Electrocardiographic Parameters Associated with Adverse Outcomes in Children with Cardiomyopathies |
title_full_unstemmed | Electrocardiographic Parameters Associated with Adverse Outcomes in Children with Cardiomyopathies |
title_short | Electrocardiographic Parameters Associated with Adverse Outcomes in Children with Cardiomyopathies |
title_sort | electrocardiographic parameters associated with adverse outcomes in children with cardiomyopathies |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738383/ https://www.ncbi.nlm.nih.gov/pubmed/36498505 http://dx.doi.org/10.3390/jcm11236930 |
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