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Oncolytic Viruses for the Treatment of Bladder Cancer: Advances, Challenges, and Prospects

Bladder cancer is one of the most prevalent cancers. Despite recent advancements in bladder cancer therapy, new strategies are still required for improving patient outcomes, particularly for those who experienced Bacille Calmette–Guerin failure and those with locally advanced or metastatic bladder c...

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Detalles Bibliográficos
Autores principales: Hu, Henglong, Xia, Qidong, Hu, Jia, Wang, Shaogang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738443/
https://www.ncbi.nlm.nih.gov/pubmed/36498574
http://dx.doi.org/10.3390/jcm11236997
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author Hu, Henglong
Xia, Qidong
Hu, Jia
Wang, Shaogang
author_facet Hu, Henglong
Xia, Qidong
Hu, Jia
Wang, Shaogang
author_sort Hu, Henglong
collection PubMed
description Bladder cancer is one of the most prevalent cancers. Despite recent advancements in bladder cancer therapy, new strategies are still required for improving patient outcomes, particularly for those who experienced Bacille Calmette–Guerin failure and those with locally advanced or metastatic bladder cancer. Oncolytic viruses are either naturally occurring or purposefully engineered viruses that have the ability to selectively infect and lyse tumor cells while avoiding harming healthy cells. In light of this, oncolytic viruses serve as a novel and promising immunotherapeutic strategy for bladder cancer. A wide diversity of viruses, including adenoviruses, herpes simplex virus, coxsackievirus, Newcastle disease virus, vesicular stomatitis virus, alphavirus, and vaccinia virus, have been studied in many preclinical and clinical studies for their potential as oncolytic agents for bladder cancer. This review aims to provide an overview of the advances in oncolytic viruses for the treatment of bladder cancer and highlights the challenges and research directions for the future.
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spelling pubmed-97384432022-12-11 Oncolytic Viruses for the Treatment of Bladder Cancer: Advances, Challenges, and Prospects Hu, Henglong Xia, Qidong Hu, Jia Wang, Shaogang J Clin Med Review Bladder cancer is one of the most prevalent cancers. Despite recent advancements in bladder cancer therapy, new strategies are still required for improving patient outcomes, particularly for those who experienced Bacille Calmette–Guerin failure and those with locally advanced or metastatic bladder cancer. Oncolytic viruses are either naturally occurring or purposefully engineered viruses that have the ability to selectively infect and lyse tumor cells while avoiding harming healthy cells. In light of this, oncolytic viruses serve as a novel and promising immunotherapeutic strategy for bladder cancer. A wide diversity of viruses, including adenoviruses, herpes simplex virus, coxsackievirus, Newcastle disease virus, vesicular stomatitis virus, alphavirus, and vaccinia virus, have been studied in many preclinical and clinical studies for their potential as oncolytic agents for bladder cancer. This review aims to provide an overview of the advances in oncolytic viruses for the treatment of bladder cancer and highlights the challenges and research directions for the future. MDPI 2022-11-26 /pmc/articles/PMC9738443/ /pubmed/36498574 http://dx.doi.org/10.3390/jcm11236997 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hu, Henglong
Xia, Qidong
Hu, Jia
Wang, Shaogang
Oncolytic Viruses for the Treatment of Bladder Cancer: Advances, Challenges, and Prospects
title Oncolytic Viruses for the Treatment of Bladder Cancer: Advances, Challenges, and Prospects
title_full Oncolytic Viruses for the Treatment of Bladder Cancer: Advances, Challenges, and Prospects
title_fullStr Oncolytic Viruses for the Treatment of Bladder Cancer: Advances, Challenges, and Prospects
title_full_unstemmed Oncolytic Viruses for the Treatment of Bladder Cancer: Advances, Challenges, and Prospects
title_short Oncolytic Viruses for the Treatment of Bladder Cancer: Advances, Challenges, and Prospects
title_sort oncolytic viruses for the treatment of bladder cancer: advances, challenges, and prospects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738443/
https://www.ncbi.nlm.nih.gov/pubmed/36498574
http://dx.doi.org/10.3390/jcm11236997
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