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Oncolytic Viruses for the Treatment of Bladder Cancer: Advances, Challenges, and Prospects
Bladder cancer is one of the most prevalent cancers. Despite recent advancements in bladder cancer therapy, new strategies are still required for improving patient outcomes, particularly for those who experienced Bacille Calmette–Guerin failure and those with locally advanced or metastatic bladder c...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738443/ https://www.ncbi.nlm.nih.gov/pubmed/36498574 http://dx.doi.org/10.3390/jcm11236997 |
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author | Hu, Henglong Xia, Qidong Hu, Jia Wang, Shaogang |
author_facet | Hu, Henglong Xia, Qidong Hu, Jia Wang, Shaogang |
author_sort | Hu, Henglong |
collection | PubMed |
description | Bladder cancer is one of the most prevalent cancers. Despite recent advancements in bladder cancer therapy, new strategies are still required for improving patient outcomes, particularly for those who experienced Bacille Calmette–Guerin failure and those with locally advanced or metastatic bladder cancer. Oncolytic viruses are either naturally occurring or purposefully engineered viruses that have the ability to selectively infect and lyse tumor cells while avoiding harming healthy cells. In light of this, oncolytic viruses serve as a novel and promising immunotherapeutic strategy for bladder cancer. A wide diversity of viruses, including adenoviruses, herpes simplex virus, coxsackievirus, Newcastle disease virus, vesicular stomatitis virus, alphavirus, and vaccinia virus, have been studied in many preclinical and clinical studies for their potential as oncolytic agents for bladder cancer. This review aims to provide an overview of the advances in oncolytic viruses for the treatment of bladder cancer and highlights the challenges and research directions for the future. |
format | Online Article Text |
id | pubmed-9738443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97384432022-12-11 Oncolytic Viruses for the Treatment of Bladder Cancer: Advances, Challenges, and Prospects Hu, Henglong Xia, Qidong Hu, Jia Wang, Shaogang J Clin Med Review Bladder cancer is one of the most prevalent cancers. Despite recent advancements in bladder cancer therapy, new strategies are still required for improving patient outcomes, particularly for those who experienced Bacille Calmette–Guerin failure and those with locally advanced or metastatic bladder cancer. Oncolytic viruses are either naturally occurring or purposefully engineered viruses that have the ability to selectively infect and lyse tumor cells while avoiding harming healthy cells. In light of this, oncolytic viruses serve as a novel and promising immunotherapeutic strategy for bladder cancer. A wide diversity of viruses, including adenoviruses, herpes simplex virus, coxsackievirus, Newcastle disease virus, vesicular stomatitis virus, alphavirus, and vaccinia virus, have been studied in many preclinical and clinical studies for their potential as oncolytic agents for bladder cancer. This review aims to provide an overview of the advances in oncolytic viruses for the treatment of bladder cancer and highlights the challenges and research directions for the future. MDPI 2022-11-26 /pmc/articles/PMC9738443/ /pubmed/36498574 http://dx.doi.org/10.3390/jcm11236997 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hu, Henglong Xia, Qidong Hu, Jia Wang, Shaogang Oncolytic Viruses for the Treatment of Bladder Cancer: Advances, Challenges, and Prospects |
title | Oncolytic Viruses for the Treatment of Bladder Cancer: Advances, Challenges, and Prospects |
title_full | Oncolytic Viruses for the Treatment of Bladder Cancer: Advances, Challenges, and Prospects |
title_fullStr | Oncolytic Viruses for the Treatment of Bladder Cancer: Advances, Challenges, and Prospects |
title_full_unstemmed | Oncolytic Viruses for the Treatment of Bladder Cancer: Advances, Challenges, and Prospects |
title_short | Oncolytic Viruses for the Treatment of Bladder Cancer: Advances, Challenges, and Prospects |
title_sort | oncolytic viruses for the treatment of bladder cancer: advances, challenges, and prospects |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738443/ https://www.ncbi.nlm.nih.gov/pubmed/36498574 http://dx.doi.org/10.3390/jcm11236997 |
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