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Psychiatric Symptoms in Patients with Cerebral Endometriosis: A Case Report and Literature Review

Endometriosis is a systemic medical condition characterized by endometrial tissue that is abnormally implanted in extrauterine sites, including the central nervous system. In this article, we reported the case of a patient with presumed cerebral endometriosis who was diagnosed with bipolar disorder...

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Autores principales: Elefante, Camilla, Brancati, Giulio Emilio, Oragvelidze, Elene, Lattanzi, Lorenzo, Maremmani, Icro, Perugi, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738496/
https://www.ncbi.nlm.nih.gov/pubmed/36498786
http://dx.doi.org/10.3390/jcm11237212
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author Elefante, Camilla
Brancati, Giulio Emilio
Oragvelidze, Elene
Lattanzi, Lorenzo
Maremmani, Icro
Perugi, Giulio
author_facet Elefante, Camilla
Brancati, Giulio Emilio
Oragvelidze, Elene
Lattanzi, Lorenzo
Maremmani, Icro
Perugi, Giulio
author_sort Elefante, Camilla
collection PubMed
description Endometriosis is a systemic medical condition characterized by endometrial tissue that is abnormally implanted in extrauterine sites, including the central nervous system. In this article, we reported the case of a patient with presumed cerebral endometriosis who was diagnosed with bipolar disorder and panic disorder and systematically reviewed the literature for previously reported neuropsychiatric symptoms in patients with cerebral and cerebellar endometriosis. The PubMed, Scopus, and Web of Science bibliographic databases were searched according to the PRISMA guidelines. Seven previous case reports were found and described. While neurological disturbances dominated the clinical picture in the cases retrieved from the literature, our patient represented the first case to show both neurological and psychiatric manifestations. Atypical features of bipolar disorder including chronic mood instability, mixed episodes, and excitatory interepisodic symptoms were highlighted. During the neuropsychological evaluation, a dysexecutive profile consistent with frontal lobe pathology was evidenced. We hypothesized that the course and features of the illness were largely influenced by the presence of documented brain lesions compatible with endometrial implants, especially in the frontal region. Accordingly, patients with endometriosis who exhibit neurological as well as mental symptoms should be investigated for cerebral lesions.
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spelling pubmed-97384962022-12-11 Psychiatric Symptoms in Patients with Cerebral Endometriosis: A Case Report and Literature Review Elefante, Camilla Brancati, Giulio Emilio Oragvelidze, Elene Lattanzi, Lorenzo Maremmani, Icro Perugi, Giulio J Clin Med Review Endometriosis is a systemic medical condition characterized by endometrial tissue that is abnormally implanted in extrauterine sites, including the central nervous system. In this article, we reported the case of a patient with presumed cerebral endometriosis who was diagnosed with bipolar disorder and panic disorder and systematically reviewed the literature for previously reported neuropsychiatric symptoms in patients with cerebral and cerebellar endometriosis. The PubMed, Scopus, and Web of Science bibliographic databases were searched according to the PRISMA guidelines. Seven previous case reports were found and described. While neurological disturbances dominated the clinical picture in the cases retrieved from the literature, our patient represented the first case to show both neurological and psychiatric manifestations. Atypical features of bipolar disorder including chronic mood instability, mixed episodes, and excitatory interepisodic symptoms were highlighted. During the neuropsychological evaluation, a dysexecutive profile consistent with frontal lobe pathology was evidenced. We hypothesized that the course and features of the illness were largely influenced by the presence of documented brain lesions compatible with endometrial implants, especially in the frontal region. Accordingly, patients with endometriosis who exhibit neurological as well as mental symptoms should be investigated for cerebral lesions. MDPI 2022-12-04 /pmc/articles/PMC9738496/ /pubmed/36498786 http://dx.doi.org/10.3390/jcm11237212 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Elefante, Camilla
Brancati, Giulio Emilio
Oragvelidze, Elene
Lattanzi, Lorenzo
Maremmani, Icro
Perugi, Giulio
Psychiatric Symptoms in Patients with Cerebral Endometriosis: A Case Report and Literature Review
title Psychiatric Symptoms in Patients with Cerebral Endometriosis: A Case Report and Literature Review
title_full Psychiatric Symptoms in Patients with Cerebral Endometriosis: A Case Report and Literature Review
title_fullStr Psychiatric Symptoms in Patients with Cerebral Endometriosis: A Case Report and Literature Review
title_full_unstemmed Psychiatric Symptoms in Patients with Cerebral Endometriosis: A Case Report and Literature Review
title_short Psychiatric Symptoms in Patients with Cerebral Endometriosis: A Case Report and Literature Review
title_sort psychiatric symptoms in patients with cerebral endometriosis: a case report and literature review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738496/
https://www.ncbi.nlm.nih.gov/pubmed/36498786
http://dx.doi.org/10.3390/jcm11237212
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