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Expression of c-MET in Estrogen Receptor Positive and HER2 Negative Resected Breast Cancer Correlated with a Poor Prognosis

Introduction: The mesenchymal-epithelial transition factor (c-MET) receptor is overexpressed in about 14–54% of invasive breast cancers, but its prognostic value in clinical practice is still unclear. Methods: In order to investigate the relationship between c-MET expression levels and prognosis, we...

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Autores principales: Iovino, Francesco, Diana, Anna, Carlino, Francesca, Ferraraccio, Franca, Antoniol, Giuliano, Fisone, Francesca, Perrone, Alessandra, Zito Marino, Federica, Panarese, Iacopo, Tathode, Madhura S., Caraglia, Michele, Gatta, Gianluca, Ruggiero, Roberto, Parisi, Simona, De Vita, Ferdinando, Ciardiello, Fortunato, Docimo, Ludovico, Orditura, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738605/
https://www.ncbi.nlm.nih.gov/pubmed/36498560
http://dx.doi.org/10.3390/jcm11236987
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author Iovino, Francesco
Diana, Anna
Carlino, Francesca
Ferraraccio, Franca
Antoniol, Giuliano
Fisone, Francesca
Perrone, Alessandra
Zito Marino, Federica
Panarese, Iacopo
Tathode, Madhura S.
Caraglia, Michele
Gatta, Gianluca
Ruggiero, Roberto
Parisi, Simona
De Vita, Ferdinando
Ciardiello, Fortunato
Docimo, Ludovico
Orditura, Michele
author_facet Iovino, Francesco
Diana, Anna
Carlino, Francesca
Ferraraccio, Franca
Antoniol, Giuliano
Fisone, Francesca
Perrone, Alessandra
Zito Marino, Federica
Panarese, Iacopo
Tathode, Madhura S.
Caraglia, Michele
Gatta, Gianluca
Ruggiero, Roberto
Parisi, Simona
De Vita, Ferdinando
Ciardiello, Fortunato
Docimo, Ludovico
Orditura, Michele
author_sort Iovino, Francesco
collection PubMed
description Introduction: The mesenchymal-epithelial transition factor (c-MET) receptor is overexpressed in about 14–54% of invasive breast cancers, but its prognostic value in clinical practice is still unclear. Methods: In order to investigate the relationship between c-MET expression levels and prognosis, we retrospectively reviewed the clinical features and outcomes of 105 women with estrogen receptor positive HER2 negative (ER+/HER2-) resected breast cancer. We used the Kaplan Meier method to estimate Disease Free Survival (DFS) and Breast Cancer Specific Survival (BCSS) in the subgroups of patients with high (≥50%) and low (<50%) c-MET expression. Univariate and multivariate Cox proportional regression models were performed to assess the prognostic impact of clinicopathological parameters for DFS an BCSS. Results: High c-MET values significantly correlated with tumor size, high Ki67 and low (<20%) progesterone receptor expression. At a median follow up of 60 months, patients with high c-MET tumor had significantly worse (p = 0.00026) and BCSS (p = 0.0013). Univariate analysis showed a significant association between large tumor size, elevated Ki67, c-MET values and increased risk of recurrence or death. The multivariate COX regression model showed that tumor size and high c-MET expression were independent predictors of DFS (p = 0.019 and p = 0.022). Moreover, large tumor size was associated with significantly higher risk of cancer related death at multivariate analysis (p = 0.017), while a trend towards a poorer survival was registered in the high c-MET levels cohort (p = 0.084). Conclusions: In our series, high c-MET expression correlated with poor survival outcomes. Further studies are warranted to validate the clinical relevance and applicability of c-MET as a prognostic factor in ER+/HER2- early BC.
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spelling pubmed-97386052022-12-11 Expression of c-MET in Estrogen Receptor Positive and HER2 Negative Resected Breast Cancer Correlated with a Poor Prognosis Iovino, Francesco Diana, Anna Carlino, Francesca Ferraraccio, Franca Antoniol, Giuliano Fisone, Francesca Perrone, Alessandra Zito Marino, Federica Panarese, Iacopo Tathode, Madhura S. Caraglia, Michele Gatta, Gianluca Ruggiero, Roberto Parisi, Simona De Vita, Ferdinando Ciardiello, Fortunato Docimo, Ludovico Orditura, Michele J Clin Med Article Introduction: The mesenchymal-epithelial transition factor (c-MET) receptor is overexpressed in about 14–54% of invasive breast cancers, but its prognostic value in clinical practice is still unclear. Methods: In order to investigate the relationship between c-MET expression levels and prognosis, we retrospectively reviewed the clinical features and outcomes of 105 women with estrogen receptor positive HER2 negative (ER+/HER2-) resected breast cancer. We used the Kaplan Meier method to estimate Disease Free Survival (DFS) and Breast Cancer Specific Survival (BCSS) in the subgroups of patients with high (≥50%) and low (<50%) c-MET expression. Univariate and multivariate Cox proportional regression models were performed to assess the prognostic impact of clinicopathological parameters for DFS an BCSS. Results: High c-MET values significantly correlated with tumor size, high Ki67 and low (<20%) progesterone receptor expression. At a median follow up of 60 months, patients with high c-MET tumor had significantly worse (p = 0.00026) and BCSS (p = 0.0013). Univariate analysis showed a significant association between large tumor size, elevated Ki67, c-MET values and increased risk of recurrence or death. The multivariate COX regression model showed that tumor size and high c-MET expression were independent predictors of DFS (p = 0.019 and p = 0.022). Moreover, large tumor size was associated with significantly higher risk of cancer related death at multivariate analysis (p = 0.017), while a trend towards a poorer survival was registered in the high c-MET levels cohort (p = 0.084). Conclusions: In our series, high c-MET expression correlated with poor survival outcomes. Further studies are warranted to validate the clinical relevance and applicability of c-MET as a prognostic factor in ER+/HER2- early BC. MDPI 2022-11-26 /pmc/articles/PMC9738605/ /pubmed/36498560 http://dx.doi.org/10.3390/jcm11236987 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Iovino, Francesco
Diana, Anna
Carlino, Francesca
Ferraraccio, Franca
Antoniol, Giuliano
Fisone, Francesca
Perrone, Alessandra
Zito Marino, Federica
Panarese, Iacopo
Tathode, Madhura S.
Caraglia, Michele
Gatta, Gianluca
Ruggiero, Roberto
Parisi, Simona
De Vita, Ferdinando
Ciardiello, Fortunato
Docimo, Ludovico
Orditura, Michele
Expression of c-MET in Estrogen Receptor Positive and HER2 Negative Resected Breast Cancer Correlated with a Poor Prognosis
title Expression of c-MET in Estrogen Receptor Positive and HER2 Negative Resected Breast Cancer Correlated with a Poor Prognosis
title_full Expression of c-MET in Estrogen Receptor Positive and HER2 Negative Resected Breast Cancer Correlated with a Poor Prognosis
title_fullStr Expression of c-MET in Estrogen Receptor Positive and HER2 Negative Resected Breast Cancer Correlated with a Poor Prognosis
title_full_unstemmed Expression of c-MET in Estrogen Receptor Positive and HER2 Negative Resected Breast Cancer Correlated with a Poor Prognosis
title_short Expression of c-MET in Estrogen Receptor Positive and HER2 Negative Resected Breast Cancer Correlated with a Poor Prognosis
title_sort expression of c-met in estrogen receptor positive and her2 negative resected breast cancer correlated with a poor prognosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738605/
https://www.ncbi.nlm.nih.gov/pubmed/36498560
http://dx.doi.org/10.3390/jcm11236987
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