Cargando…

Synthetic, Cell-Derived, Brain-Derived, and Recombinant β-Amyloid: Modelling Alzheimer’s Disease for Research and Drug Development

Alzheimer’s disease (AD) is the most common cause of dementia in the elderly, characterised by the accumulation of senile plaques and tau tangles, neurodegeneration, and neuroinflammation in the brain. The development of AD is a pathological cascade starting according to the amyloid hypothesis with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Varshavskaya, Kseniya B., Mitkevich, Vladimir A., Makarov, Alexander A., Barykin, Evgeny P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738609/ https://www.ncbi.nlm.nih.gov/pubmed/36499362 http://dx.doi.org/10.3390/ijms232315036

Ejemplares similares

Amyloid β Modification: A Key to the Sporadic Alzheimer's Disease?
por: Barykin, Evgeny P., et al.
Publicado: (2017)

Phosphorylation and Dephosphorylation of Beta-Amyloid Peptide in Model Cell Cultures: The Role of Cellular Protein Kinases and Phosphatases
por: Barykin, Evgeny P., et al.
Publicado: (2023)

Distinct Effects of Beta-Amyloid, Its Isomerized and Phosphorylated Forms on the Redox Status and Mitochondrial Functioning of the Blood–Brain Barrier Endothelium
por: Petrovskaya, Aleksandra V., et al.
Publicado: (2022)

Intravenously Injected Amyloid-β Peptide With Isomerized Asp7 and Phosphorylated Ser8 Residues Inhibits Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice Model of Alzheimer’s Disease
por: Kozin, Sergey A., et al.
Publicado: (2018)

Zn-dependent β-amyloid Aggregation and its Reversal by the Tetrapeptide HAEE
por: Mitkevich, Vladimir A, et al.
Publicado: (2023)

The Dynamics of β-Amyloid Proteoforms Accumulation in the Brain of a 5xFAD Mouse Model of Alzheimer’s Disease
por: Bugrova, Anna E., et al.
Publicado: (2021)

Phosphorylation of the Amyloid-Beta Peptide Inhibits Zinc-Dependent Aggregation, Prevents Na,K-ATPase Inhibition, and Reduces Cerebral Plaque Deposition
por: Barykin, Evgeny P., et al.
Publicado: (2018)

Extracellular GAPDH Promotes Alzheimer Disease Progression by Enhancing Amyloid-β Aggregation and Cytotoxicity
por: Lazarev, Vladimir F, et al.
Publicado: (2021)

The English (H6R) Mutation of the Alzheimer’s Disease Amyloid-β Peptide Modulates Its Zinc-Induced Aggregation
por: Radko, Sergey P., et al.
Publicado: (2020)

Molecular Mechanism of Zinc-Dependent Oligomerization of Alzheimer’s Amyloid-β with Taiwan (D7H) Mutation
por: Kechko, Olga I., et al.
Publicado: (2023)

Na,K-ATPase Acts as a Beta-Amyloid Receptor Triggering Src Kinase Activation
por: Petrushanko, Irina Yu., et al.
Publicado: (2022)

Anionic Oligothiophenes Compete for Binding of X‐34 but not PIB to Recombinant Aβ Amyloid Fibrils and Alzheimer's Disease Brain‐Derived Aβ
por: Bäck, Marcus, et al.
Publicado: (2016)

Isomerization of Asp7 in Beta-Amyloid Enhances Inhibition of the α7 Nicotinic Receptor and Promotes Neurotoxicity
por: Barykin, Evgeny P., et al.
Publicado: (2019)

Structural Insight into an Alzheimer’s Brain-Derived Spherical Assembly of Amyloid β by Solid-State NMR
por: Parthasarathy, Sudhakar, et al.
Publicado: (2015)

Amyloid-β peptides slightly affect lifespan or antimicrobial peptide gene expression in Drosophila melanogaster
por: Shaposhnikov, Mikhail V., et al.
Publicado: (2020)

Derivation of cutoffs for the Elecsys(®) amyloid β (1–42) assay in Alzheimer's disease
por: Shaw, Leslie M., et al.
Publicado: (2018)

Gut-derived β-amyloid: Likely a centerpiece of the gut–brain axis contributing to Alzheimer’s pathogenesis
por: Jin, Jinghua, et al.
Publicado: (2023)

MRAβ: A multimodal MRI‐derived amyloid‐β biomarker for Alzheimer's disease
por: Zhang, Yu, et al.
Publicado: (2023)

Docking and Molecular Dynamics-Based Identification of Interaction between Various Beta-Amyloid Isoforms and RAGE Receptor
por: Tolstova, Anna P., et al.
Publicado: (2022)

Structural polymorphism and cytotoxicity of brain‐derived β‐amyloid extracts
por: Al Adem, Kenana, et al.
Publicado: (2023)

Amyloid-β with isomerized Asp7 cytotoxicity is coupled to protein phosphorylation
por: Zatsepina, O. G., et al.
Publicado: (2018)

Isomerization of Asp7 leads to increased toxic effect of amyloid-β42 on human neuronal cells
por: Mitkevich, V A, et al.
Publicado: (2013)

HSP70 protects human neuroblastoma cells from apoptosis and oxidative stress induced by amyloid peptide isoAsp7-Aβ(1–42)
por: Yurinskaya, M M, et al.
Publicado: (2015)

Dual-target ligand discovery for Alzheimer’s disease: triphenylphosphoranylidene derivatives as inhibitors of acetylcholinesterase and β-amyloid aggregation
por: El-Hussieny, Marwa, et al.
Publicado: (2023)

Alzheimer's disease-related amyloid-β induces synaptotoxicity in human iPS cell-derived neurons
por: Nieweg, K, et al.
Publicado: (2015)

Pharmacokinetics and Molecular Modeling Indicate nAChRα4-Derived Peptide HAEE Goes through the Blood–Brain Barrier
por: Zolotarev, Yurii A., et al.
Publicado: (2021)

Modulation of Amyloid-β and Tau in Alzheimer’s Disease Plasma Neuronal-Derived Extracellular Vesicles by Cerebrolysin® and Donepezil
por: Alvarez, X. Anton, et al.
Publicado: (2022)

Natural and Synthetic Derivatives of Hydroxycinnamic Acid Modulating the Pathological Transformation of Amyloidogenic Proteins
por: Muronetz, Vladimir I., et al.
Publicado: (2020)

Synthetic Optimizations for Gram-Scale Preparation of 1-O-Methyl d-Glycero-α-d-gluco-heptoside 7-Phosphate from d-Glucose
por: Potapov, Konstantin V., et al.
Publicado: (2022)

Food protein-derived amyloids do not accelerate amyloid β aggregation
por: Rahman, M. Mahafuzur, et al.
Publicado: (2023)

Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer’s disease
por: Lee, Ming-Che, et al.
Publicado: (2018)

Brain amyloid β protein and memory disruption in Alzheimer’s disease
por: Xia, Weiming
Publicado: (2010)

Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus
por: Muñoz-Castro, Clara, et al.
Publicado: (2023)

Synthetic amyloid-β oligomers drive early pathological progression of Alzheimer’s disease in nonhuman primates
por: Yue, Feng, et al.
Publicado: (2021)

Beta-amyloid induces apoptosis of neuronal cells by inhibition of the Arg/N-end rule pathway proteolytic activity
por: Kechko, Olga I., et al.
Publicado: (2019)

Fluselenamyl: A Novel Benzoselenazole Derivative for PET Detection of Amyloid Plaques (Aβ) in Alzheimer’s Disease
por: Sundaram, G. S. M., et al.
Publicado: (2016)

Immunization with Small Amyloid-β-derived Cyclopeptide Conjugates Diminishes Amyloid-β-Induced Neurodegeneration in Mice
por: Mulder, Cornelis K., et al.
Publicado: (2016)

Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model
por: Kim, DaWon, et al.
Publicado: (2020)

Amyloid-β-Derived Peptidomimetics Inhibits Tau Aggregation
por: Gorantla, Nalini V., et al.
Publicado: (2021)

Alzheimer's Disease Amyloid-β Links Lens and Brain Pathology in Down Syndrome
por: Moncaster, Juliet A., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_cg4eqn1sdsp4bca9m9dhmm9gbn