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Longitudinal Associations of Adherence to the Dietary World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and Dutch Healthy Diet (DHD) Recommendations with Plasma Kynurenines in Colorectal Cancer Survivors after Treatment

The tryptophan-kynurenine pathway has been linked to cancer aetiology and survivorship, and diet potentially affects metabolites of this pathway, but evidence to date is scarce. Among 247 stage I-III CRC survivors, repeated measurements were performed at 6 weeks, 6 months, and 1 year post-treatment....

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Autores principales: Holthuijsen, Daniëlle D. B., Bours, Martijn J. L., van Roekel, Eline H., Breukink, Stéphanie O., Janssen-Heijnen, Maryska L. G., Keulen, Eric T. P., Ueland, Per M., Midttun, Øivind, Brezina, Stefanie, Gigic, Biljana, Gsur, Andrea, Kok, Dieuwertje E., Ose, Jennifer, Ulrich, Cornelia M., Weijenberg, Matty P., Eussen, Simone J. P. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738623/
https://www.ncbi.nlm.nih.gov/pubmed/36501181
http://dx.doi.org/10.3390/nu14235151
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author Holthuijsen, Daniëlle D. B.
Bours, Martijn J. L.
van Roekel, Eline H.
Breukink, Stéphanie O.
Janssen-Heijnen, Maryska L. G.
Keulen, Eric T. P.
Ueland, Per M.
Midttun, Øivind
Brezina, Stefanie
Gigic, Biljana
Gsur, Andrea
Kok, Dieuwertje E.
Ose, Jennifer
Ulrich, Cornelia M.
Weijenberg, Matty P.
Eussen, Simone J. P. M.
author_facet Holthuijsen, Daniëlle D. B.
Bours, Martijn J. L.
van Roekel, Eline H.
Breukink, Stéphanie O.
Janssen-Heijnen, Maryska L. G.
Keulen, Eric T. P.
Ueland, Per M.
Midttun, Øivind
Brezina, Stefanie
Gigic, Biljana
Gsur, Andrea
Kok, Dieuwertje E.
Ose, Jennifer
Ulrich, Cornelia M.
Weijenberg, Matty P.
Eussen, Simone J. P. M.
author_sort Holthuijsen, Daniëlle D. B.
collection PubMed
description The tryptophan-kynurenine pathway has been linked to cancer aetiology and survivorship, and diet potentially affects metabolites of this pathway, but evidence to date is scarce. Among 247 stage I-III CRC survivors, repeated measurements were performed at 6 weeks, 6 months, and 1 year post-treatment. Adherence to the World Cancer Research Fund/ American Institute for Cancer Research (WCRF) and Dutch Healthy Diet (DHD) recommendations was operationalized using seven-day dietary records. Plasma kynurenines of nine metabolites were analysed. Longitudinal associations of adherence to these dietary patterns and plasma kynurenines were analysed using confounder-adjusted linear mixed-models. In general, higher adherence to the dietary WCRF/AICR and DHD recommendations was associated with lower concentrations of kynurenines with pro-oxidative, pro-inflammatory, and neurotoxic properties (3-hydroxykynurenine (HK) and quinolinic acid (QA)), and higher concentrations of kynurenines with anti-oxidative, anti-inflammatory, and neuroprotective properties (kynurenic acid (KA) and picolinic acid (Pic)), but associations were weak and not statistically significant. Statistically significant positive associations between individual recommendations and kynurenines were observed for: nuts with kynurenic-acid-to-quinolinic-acid ratio (KA/QA); alcohol with KA/QA, KA, and xanthurenic acid (XA); red meat with XA; and cheese with XA. Statistically significant inverse associations were observed for: nuts with kynurenine-to-tryptophan ratio (KTR) and hydroxykynurenine ratio; alcohol with KTR; red meat with 3-hydroxyanthranilic-to-3-hydroxykynurenine ratio; ultra-processed foods with XA and KA/QA; and sweetened beverages with KA/QA. Our findings suggest that CRC survivors might benefit from adhering to the dietary WCRF and DHD recommendations in the first year after treatment, as higher adherence to these dietary patterns is generally, but weakly associated with more favourable concentrations of kynurenines and their ratios. These results need to be validated in other studies.
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spelling pubmed-97386232022-12-11 Longitudinal Associations of Adherence to the Dietary World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and Dutch Healthy Diet (DHD) Recommendations with Plasma Kynurenines in Colorectal Cancer Survivors after Treatment Holthuijsen, Daniëlle D. B. Bours, Martijn J. L. van Roekel, Eline H. Breukink, Stéphanie O. Janssen-Heijnen, Maryska L. G. Keulen, Eric T. P. Ueland, Per M. Midttun, Øivind Brezina, Stefanie Gigic, Biljana Gsur, Andrea Kok, Dieuwertje E. Ose, Jennifer Ulrich, Cornelia M. Weijenberg, Matty P. Eussen, Simone J. P. M. Nutrients Article The tryptophan-kynurenine pathway has been linked to cancer aetiology and survivorship, and diet potentially affects metabolites of this pathway, but evidence to date is scarce. Among 247 stage I-III CRC survivors, repeated measurements were performed at 6 weeks, 6 months, and 1 year post-treatment. Adherence to the World Cancer Research Fund/ American Institute for Cancer Research (WCRF) and Dutch Healthy Diet (DHD) recommendations was operationalized using seven-day dietary records. Plasma kynurenines of nine metabolites were analysed. Longitudinal associations of adherence to these dietary patterns and plasma kynurenines were analysed using confounder-adjusted linear mixed-models. In general, higher adherence to the dietary WCRF/AICR and DHD recommendations was associated with lower concentrations of kynurenines with pro-oxidative, pro-inflammatory, and neurotoxic properties (3-hydroxykynurenine (HK) and quinolinic acid (QA)), and higher concentrations of kynurenines with anti-oxidative, anti-inflammatory, and neuroprotective properties (kynurenic acid (KA) and picolinic acid (Pic)), but associations were weak and not statistically significant. Statistically significant positive associations between individual recommendations and kynurenines were observed for: nuts with kynurenic-acid-to-quinolinic-acid ratio (KA/QA); alcohol with KA/QA, KA, and xanthurenic acid (XA); red meat with XA; and cheese with XA. Statistically significant inverse associations were observed for: nuts with kynurenine-to-tryptophan ratio (KTR) and hydroxykynurenine ratio; alcohol with KTR; red meat with 3-hydroxyanthranilic-to-3-hydroxykynurenine ratio; ultra-processed foods with XA and KA/QA; and sweetened beverages with KA/QA. Our findings suggest that CRC survivors might benefit from adhering to the dietary WCRF and DHD recommendations in the first year after treatment, as higher adherence to these dietary patterns is generally, but weakly associated with more favourable concentrations of kynurenines and their ratios. These results need to be validated in other studies. MDPI 2022-12-03 /pmc/articles/PMC9738623/ /pubmed/36501181 http://dx.doi.org/10.3390/nu14235151 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Holthuijsen, Daniëlle D. B.
Bours, Martijn J. L.
van Roekel, Eline H.
Breukink, Stéphanie O.
Janssen-Heijnen, Maryska L. G.
Keulen, Eric T. P.
Ueland, Per M.
Midttun, Øivind
Brezina, Stefanie
Gigic, Biljana
Gsur, Andrea
Kok, Dieuwertje E.
Ose, Jennifer
Ulrich, Cornelia M.
Weijenberg, Matty P.
Eussen, Simone J. P. M.
Longitudinal Associations of Adherence to the Dietary World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and Dutch Healthy Diet (DHD) Recommendations with Plasma Kynurenines in Colorectal Cancer Survivors after Treatment
title Longitudinal Associations of Adherence to the Dietary World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and Dutch Healthy Diet (DHD) Recommendations with Plasma Kynurenines in Colorectal Cancer Survivors after Treatment
title_full Longitudinal Associations of Adherence to the Dietary World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and Dutch Healthy Diet (DHD) Recommendations with Plasma Kynurenines in Colorectal Cancer Survivors after Treatment
title_fullStr Longitudinal Associations of Adherence to the Dietary World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and Dutch Healthy Diet (DHD) Recommendations with Plasma Kynurenines in Colorectal Cancer Survivors after Treatment
title_full_unstemmed Longitudinal Associations of Adherence to the Dietary World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and Dutch Healthy Diet (DHD) Recommendations with Plasma Kynurenines in Colorectal Cancer Survivors after Treatment
title_short Longitudinal Associations of Adherence to the Dietary World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and Dutch Healthy Diet (DHD) Recommendations with Plasma Kynurenines in Colorectal Cancer Survivors after Treatment
title_sort longitudinal associations of adherence to the dietary world cancer research fund/american institute for cancer research (wcrf/aicr) and dutch healthy diet (dhd) recommendations with plasma kynurenines in colorectal cancer survivors after treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738623/
https://www.ncbi.nlm.nih.gov/pubmed/36501181
http://dx.doi.org/10.3390/nu14235151
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