Integrating Pharmacogenomics Data-Driven Computational Drug Prediction with Single-Cell RNAseq to Demonstrate the Efficacy of a NAMPT Inhibitor against Aggressive, Taxane-Resistant, and Stem-like Cells in Lethal Prostate Cancer

SIMPLE SUMMARY: Prostate cancer (PCa) is the second most common cancer and the second leading cause of cancer deaths in US men. Resistance to standard medical castration and secondary taxane-based chemotherapy, the presence of cancer stem-like cells representing epithelial to mesenchymal transdiffer...

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Detalles Bibliográficos
Autores principales: Mazumder, Suman, Mitra Ghosh, Taraswi, Mukherjee, Ujjal K., Chakravarti, Sayak, Amiri, Farshad, Waliagha, Razan S., Hemmati, Farnaz, Mistriotis, Panagiotis, Ahmed, Salsabil, Elhussin, Isra, Salam, Ahmad-Bin, Dean-Colomb, Windy, Yates, Clayton, Arnold, Robert D., Mitra, Amit K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738762/
https://www.ncbi.nlm.nih.gov/pubmed/36497496
http://dx.doi.org/10.3390/cancers14236009

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