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Systematic Investigation of the Diagnostic and Prognostic Impact of LINC01087 in Human Cancers

SIMPLE SUMMARY: LINC01087 is a recently described long non-coding RNA. Its potential implication within oncology is being increasingly acknowledged. Here, we explored the clinical interest of LINC01087 in the diagnosis and prognostication of multiple cancer types. A series of in-depth in silico anal...

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Autores principales: De Palma, Fatima Domenica Elisa, Carbonnier, Vincent, Salvatore, Francesco, Kroemer, Guido, Pol, Jonathan G., Maiuri, Maria Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738797/
https://www.ncbi.nlm.nih.gov/pubmed/36497462
http://dx.doi.org/10.3390/cancers14235980
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author De Palma, Fatima Domenica Elisa
Carbonnier, Vincent
Salvatore, Francesco
Kroemer, Guido
Pol, Jonathan G.
Maiuri, Maria Chiara
author_facet De Palma, Fatima Domenica Elisa
Carbonnier, Vincent
Salvatore, Francesco
Kroemer, Guido
Pol, Jonathan G.
Maiuri, Maria Chiara
author_sort De Palma, Fatima Domenica Elisa
collection PubMed
description SIMPLE SUMMARY: LINC01087 is a recently described long non-coding RNA. Its potential implication within oncology is being increasingly acknowledged. Here, we explored the clinical interest of LINC01087 in the diagnosis and prognostication of multiple cancer types. A series of in-depth in silico analyses revealed LINC01087 as a potential diagnostic indicator of some hormone-related tumors, including breast cancer (BC), ovarian carcinoma, and testicular germ cell tumors, as well as other cancer histotypes, such as esophageal and stomach cancers. Moreover, LINC01087 appears as a prognostic indicator in BC and renal papillary cell carcinoma. Therefore, the quantitation of LINC01087 in tissue specimens might have a clinical utility to improve the management of these pathologies in the future. ABSTRACT: (1) Background: Long non-coding RNAs may constitute epigenetic biomarkers for the diagnosis, prognosis, and therapeutic response of a variety of tumors. In this context, we aimed at assessing the diagnostic and prognostic value of the recently described long intergenic non-coding RNA 01087 (LINC01087) in human cancers. (2) Methods: We studied the expression of LINC01087 across 30 oncological indications by interrogating public resources. Data extracted from the TCGA and GTEx databases were exploited to plot receiver operating characteristic curves (ROC) and determine the diagnostic performance of LINC01087. Survival data from TCGA and KM-Plotter directories allowed us to graph Kaplan–Meier curves and evaluate the prognostic value of LINC01087. To investigate the function of LINC01087, gene ontology (GO) annotation and Kyoto Encyclopedia of Gene and Genomes (KEGG) enrichment analyses were performed. Furthermore, interactions between LINC01087 and both miRNA and mRNA were studied by means of bioinformatics tools. (3) Results: LINC01087 was significantly deregulated in 7 out of 30 cancers, showing a predominant upregulation. Notably, it was overexpressed in breast (BC), esophageal (ESCA), and ovarian (OV) cancers, as well as lung squamous cell carcinoma (LUSC), stomach adenocarcinoma (STAD), and uterine carcinosarcoma (UCS). By contrast, LINC01087 displayed downregulation in testicular germ cell tumors (TGCT). ROC curve analyses identified LINC01087 as a potential diagnostic indicator in BC, ESCA, OV, STAD, and TGCT. Moreover, high and low expression of LINC01087 predicted a favorable prognosis in BC and papillary cell carcinoma, respectively. In silico analyses indicated that deregulation of LINC01087 in cancer was associated with a modulation of genes related to ion channel, transporter, and peptide receptor activity. (4) Conclusions: the quantification of an altered abundance of LINC01087 in tissue specimens might be clinically useful for the diagnosis and prognosis of some hormone-related tumors, including BC, OV, and TGCT, as well as other cancer types such as ESCA and STAD. Moreover, our study revealed the potential of LINC01087 (and perhaps other lncRNAs) to regulate neuroactive molecules in cancer.
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spelling pubmed-97387972022-12-11 Systematic Investigation of the Diagnostic and Prognostic Impact of LINC01087 in Human Cancers De Palma, Fatima Domenica Elisa Carbonnier, Vincent Salvatore, Francesco Kroemer, Guido Pol, Jonathan G. Maiuri, Maria Chiara Cancers (Basel) Article SIMPLE SUMMARY: LINC01087 is a recently described long non-coding RNA. Its potential implication within oncology is being increasingly acknowledged. Here, we explored the clinical interest of LINC01087 in the diagnosis and prognostication of multiple cancer types. A series of in-depth in silico analyses revealed LINC01087 as a potential diagnostic indicator of some hormone-related tumors, including breast cancer (BC), ovarian carcinoma, and testicular germ cell tumors, as well as other cancer histotypes, such as esophageal and stomach cancers. Moreover, LINC01087 appears as a prognostic indicator in BC and renal papillary cell carcinoma. Therefore, the quantitation of LINC01087 in tissue specimens might have a clinical utility to improve the management of these pathologies in the future. ABSTRACT: (1) Background: Long non-coding RNAs may constitute epigenetic biomarkers for the diagnosis, prognosis, and therapeutic response of a variety of tumors. In this context, we aimed at assessing the diagnostic and prognostic value of the recently described long intergenic non-coding RNA 01087 (LINC01087) in human cancers. (2) Methods: We studied the expression of LINC01087 across 30 oncological indications by interrogating public resources. Data extracted from the TCGA and GTEx databases were exploited to plot receiver operating characteristic curves (ROC) and determine the diagnostic performance of LINC01087. Survival data from TCGA and KM-Plotter directories allowed us to graph Kaplan–Meier curves and evaluate the prognostic value of LINC01087. To investigate the function of LINC01087, gene ontology (GO) annotation and Kyoto Encyclopedia of Gene and Genomes (KEGG) enrichment analyses were performed. Furthermore, interactions between LINC01087 and both miRNA and mRNA were studied by means of bioinformatics tools. (3) Results: LINC01087 was significantly deregulated in 7 out of 30 cancers, showing a predominant upregulation. Notably, it was overexpressed in breast (BC), esophageal (ESCA), and ovarian (OV) cancers, as well as lung squamous cell carcinoma (LUSC), stomach adenocarcinoma (STAD), and uterine carcinosarcoma (UCS). By contrast, LINC01087 displayed downregulation in testicular germ cell tumors (TGCT). ROC curve analyses identified LINC01087 as a potential diagnostic indicator in BC, ESCA, OV, STAD, and TGCT. Moreover, high and low expression of LINC01087 predicted a favorable prognosis in BC and papillary cell carcinoma, respectively. In silico analyses indicated that deregulation of LINC01087 in cancer was associated with a modulation of genes related to ion channel, transporter, and peptide receptor activity. (4) Conclusions: the quantification of an altered abundance of LINC01087 in tissue specimens might be clinically useful for the diagnosis and prognosis of some hormone-related tumors, including BC, OV, and TGCT, as well as other cancer types such as ESCA and STAD. Moreover, our study revealed the potential of LINC01087 (and perhaps other lncRNAs) to regulate neuroactive molecules in cancer. MDPI 2022-12-03 /pmc/articles/PMC9738797/ /pubmed/36497462 http://dx.doi.org/10.3390/cancers14235980 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
De Palma, Fatima Domenica Elisa
Carbonnier, Vincent
Salvatore, Francesco
Kroemer, Guido
Pol, Jonathan G.
Maiuri, Maria Chiara
Systematic Investigation of the Diagnostic and Prognostic Impact of LINC01087 in Human Cancers
title Systematic Investigation of the Diagnostic and Prognostic Impact of LINC01087 in Human Cancers
title_full Systematic Investigation of the Diagnostic and Prognostic Impact of LINC01087 in Human Cancers
title_fullStr Systematic Investigation of the Diagnostic and Prognostic Impact of LINC01087 in Human Cancers
title_full_unstemmed Systematic Investigation of the Diagnostic and Prognostic Impact of LINC01087 in Human Cancers
title_short Systematic Investigation of the Diagnostic and Prognostic Impact of LINC01087 in Human Cancers
title_sort systematic investigation of the diagnostic and prognostic impact of linc01087 in human cancers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738797/
https://www.ncbi.nlm.nih.gov/pubmed/36497462
http://dx.doi.org/10.3390/cancers14235980
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