A Single Chain Fragment Variant Binding Misfolded Alpha-Synuclein Exhibits Neuroprotective and Antigen-Specific Anti-Inflammatory Properties

Introduction. Alpha synuclein (αSyn) misfolding plays a requisite role in the pathogenesis of synucleinopathies. Direct toxicity to neurons, triggering neuroinflammation as well as the spreading and seeding of αSyn pathology are essential pathogenetic underlying mechanisms. Immunotherapy in experime...

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Detalles Bibliográficos
Autores principales: Fassler, Michael, Benaim, Clara, George, Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739179/
https://www.ncbi.nlm.nih.gov/pubmed/36497081
http://dx.doi.org/10.3390/cells11233822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739179/
https://www.ncbi.nlm.nih.gov/pubmed/36497081
http://dx.doi.org/10.3390/cells11233822

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