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Discovery of a Flavonoid FM04 as a Potent Inhibitor to Reverse P-Glycoprotein-Mediated Drug Resistance in Xenografts and Improve Oral Bioavailability of Paclitaxel
Biotransformation of flavonoid dimer FD18 resulted in an active metabolite FM04. It was more druggable because of its improved physicochemical properties. FM04 (EC(50) = 83 nM) was 1.8-fold more potent than FD18 in reversing P-glycoprotein (P-gp)-mediated paclitaxel (PTX) resistance in vitro. Simila...
Autores principales: | Kan, Jason W. Y., Yan, Clare S. W., Wong, Iris L. K., Su, Xiaochun, Liu, Zhen, Chan, Tak Hang, Chow, Larry M. C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739180/ https://www.ncbi.nlm.nih.gov/pubmed/36499627 http://dx.doi.org/10.3390/ijms232315299 |
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