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NLRP3 and Gut Microbiota Homeostasis: Progress in Research
The inflammasome is a platform for inflammatory signaling, and the NLRP3 inflammasome recognizes stimuli in vitro and in vivo, and releases inflammatory cytokines that trigger inflammation and pyroptosis. In the gut, the NLRP3 inflammasome is a key sensor for protecting the body from damage and exog...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739202/ https://www.ncbi.nlm.nih.gov/pubmed/36497018 http://dx.doi.org/10.3390/cells11233758 |
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author | Pan, Hongming Jian, Yuting Wang, Feijie Yu, Shaokun Guo, Jiannan Kan, Juntao Guo, Wei |
author_facet | Pan, Hongming Jian, Yuting Wang, Feijie Yu, Shaokun Guo, Jiannan Kan, Juntao Guo, Wei |
author_sort | Pan, Hongming |
collection | PubMed |
description | The inflammasome is a platform for inflammatory signaling, and the NLRP3 inflammasome recognizes stimuli in vitro and in vivo, and releases inflammatory cytokines that trigger inflammation and pyroptosis. In the gut, the NLRP3 inflammasome is a key sensor for protecting the body from damage and exogenous pathogens. It plays a fundamental role in maintaining the stability of the gut’s immune system. We focus on the role of NLRP3 as a key node in maintaining the homeostasis of gut microbiota which has not been fully highlighted in the past; gut microbiota and innate immunity, as well as the NLRP3 inflammasome, are discussed in this article. |
format | Online Article Text |
id | pubmed-9739202 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97392022022-12-11 NLRP3 and Gut Microbiota Homeostasis: Progress in Research Pan, Hongming Jian, Yuting Wang, Feijie Yu, Shaokun Guo, Jiannan Kan, Juntao Guo, Wei Cells Commentary The inflammasome is a platform for inflammatory signaling, and the NLRP3 inflammasome recognizes stimuli in vitro and in vivo, and releases inflammatory cytokines that trigger inflammation and pyroptosis. In the gut, the NLRP3 inflammasome is a key sensor for protecting the body from damage and exogenous pathogens. It plays a fundamental role in maintaining the stability of the gut’s immune system. We focus on the role of NLRP3 as a key node in maintaining the homeostasis of gut microbiota which has not been fully highlighted in the past; gut microbiota and innate immunity, as well as the NLRP3 inflammasome, are discussed in this article. MDPI 2022-11-24 /pmc/articles/PMC9739202/ /pubmed/36497018 http://dx.doi.org/10.3390/cells11233758 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Commentary Pan, Hongming Jian, Yuting Wang, Feijie Yu, Shaokun Guo, Jiannan Kan, Juntao Guo, Wei NLRP3 and Gut Microbiota Homeostasis: Progress in Research |
title | NLRP3 and Gut Microbiota Homeostasis: Progress in Research |
title_full | NLRP3 and Gut Microbiota Homeostasis: Progress in Research |
title_fullStr | NLRP3 and Gut Microbiota Homeostasis: Progress in Research |
title_full_unstemmed | NLRP3 and Gut Microbiota Homeostasis: Progress in Research |
title_short | NLRP3 and Gut Microbiota Homeostasis: Progress in Research |
title_sort | nlrp3 and gut microbiota homeostasis: progress in research |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739202/ https://www.ncbi.nlm.nih.gov/pubmed/36497018 http://dx.doi.org/10.3390/cells11233758 |
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