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Post-Transplant Lymphoproliferative Disorder: A Rare Case of CNS Involvement following Renal Transplant
Background: Post-transplant lymphoproliferative disorders (PTLD) are rare immunosuppression complications affecting 5% of transplant patients. Isolated central nervous system (CNS)-PTLD without nodal or extra-nodal organ involvement is rarely reported and is difficult to diagnose due to the non-spec...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739215/ https://www.ncbi.nlm.nih.gov/pubmed/36498633 http://dx.doi.org/10.3390/jcm11237058 |
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author | Feindt, Austin Lara-Velazquez, Montserrat Alkhasawneh, Ahmad Rao, Dinesh Makary, Raafat Dombrowski, Keith Tavanaiepour, Daryoush Rahmathulla, Gazanfar |
author_facet | Feindt, Austin Lara-Velazquez, Montserrat Alkhasawneh, Ahmad Rao, Dinesh Makary, Raafat Dombrowski, Keith Tavanaiepour, Daryoush Rahmathulla, Gazanfar |
author_sort | Feindt, Austin |
collection | PubMed |
description | Background: Post-transplant lymphoproliferative disorders (PTLD) are rare immunosuppression complications affecting 5% of transplant patients. Isolated central nervous system (CNS)-PTLD without nodal or extra-nodal organ involvement is rarely reported and is difficult to diagnose due to the non-specific clinical manifestations and imaging features overlapping with other common CNS lesions. Case presentation: We present a case of a 72-year-old female subjected to a renal transplant 11 years ago with progressively worsening headaches and confusion. Imaging revealed vasogenic edema in the left frontal and bilateral temporal lobes. She was subjected to a craniotomy and excisional biopsy to obtain tissue for diagnostic and therapeutic interventions. Pathology examination showed atypical EBV-positive lymphoplasmacytic infiltrate, consistent with Polymorphic type PTLD. Conclusions: Patients diagnosed with PTLD need to have close monitoring of immunosuppressive medications while in the hospital. Early diagnosis is essential for patient survival with PTLD, as their health can deteriorate fast. |
format | Online Article Text |
id | pubmed-9739215 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97392152022-12-11 Post-Transplant Lymphoproliferative Disorder: A Rare Case of CNS Involvement following Renal Transplant Feindt, Austin Lara-Velazquez, Montserrat Alkhasawneh, Ahmad Rao, Dinesh Makary, Raafat Dombrowski, Keith Tavanaiepour, Daryoush Rahmathulla, Gazanfar J Clin Med Brief Report Background: Post-transplant lymphoproliferative disorders (PTLD) are rare immunosuppression complications affecting 5% of transplant patients. Isolated central nervous system (CNS)-PTLD without nodal or extra-nodal organ involvement is rarely reported and is difficult to diagnose due to the non-specific clinical manifestations and imaging features overlapping with other common CNS lesions. Case presentation: We present a case of a 72-year-old female subjected to a renal transplant 11 years ago with progressively worsening headaches and confusion. Imaging revealed vasogenic edema in the left frontal and bilateral temporal lobes. She was subjected to a craniotomy and excisional biopsy to obtain tissue for diagnostic and therapeutic interventions. Pathology examination showed atypical EBV-positive lymphoplasmacytic infiltrate, consistent with Polymorphic type PTLD. Conclusions: Patients diagnosed with PTLD need to have close monitoring of immunosuppressive medications while in the hospital. Early diagnosis is essential for patient survival with PTLD, as their health can deteriorate fast. MDPI 2022-11-29 /pmc/articles/PMC9739215/ /pubmed/36498633 http://dx.doi.org/10.3390/jcm11237058 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Feindt, Austin Lara-Velazquez, Montserrat Alkhasawneh, Ahmad Rao, Dinesh Makary, Raafat Dombrowski, Keith Tavanaiepour, Daryoush Rahmathulla, Gazanfar Post-Transplant Lymphoproliferative Disorder: A Rare Case of CNS Involvement following Renal Transplant |
title | Post-Transplant Lymphoproliferative Disorder: A Rare Case of CNS Involvement following Renal Transplant |
title_full | Post-Transplant Lymphoproliferative Disorder: A Rare Case of CNS Involvement following Renal Transplant |
title_fullStr | Post-Transplant Lymphoproliferative Disorder: A Rare Case of CNS Involvement following Renal Transplant |
title_full_unstemmed | Post-Transplant Lymphoproliferative Disorder: A Rare Case of CNS Involvement following Renal Transplant |
title_short | Post-Transplant Lymphoproliferative Disorder: A Rare Case of CNS Involvement following Renal Transplant |
title_sort | post-transplant lymphoproliferative disorder: a rare case of cns involvement following renal transplant |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739215/ https://www.ncbi.nlm.nih.gov/pubmed/36498633 http://dx.doi.org/10.3390/jcm11237058 |
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