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Post-Transplant Lymphoproliferative Disorder: A Rare Case of CNS Involvement following Renal Transplant

Background: Post-transplant lymphoproliferative disorders (PTLD) are rare immunosuppression complications affecting 5% of transplant patients. Isolated central nervous system (CNS)-PTLD without nodal or extra-nodal organ involvement is rarely reported and is difficult to diagnose due to the non-spec...

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Autores principales: Feindt, Austin, Lara-Velazquez, Montserrat, Alkhasawneh, Ahmad, Rao, Dinesh, Makary, Raafat, Dombrowski, Keith, Tavanaiepour, Daryoush, Rahmathulla, Gazanfar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739215/
https://www.ncbi.nlm.nih.gov/pubmed/36498633
http://dx.doi.org/10.3390/jcm11237058
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author Feindt, Austin
Lara-Velazquez, Montserrat
Alkhasawneh, Ahmad
Rao, Dinesh
Makary, Raafat
Dombrowski, Keith
Tavanaiepour, Daryoush
Rahmathulla, Gazanfar
author_facet Feindt, Austin
Lara-Velazquez, Montserrat
Alkhasawneh, Ahmad
Rao, Dinesh
Makary, Raafat
Dombrowski, Keith
Tavanaiepour, Daryoush
Rahmathulla, Gazanfar
author_sort Feindt, Austin
collection PubMed
description Background: Post-transplant lymphoproliferative disorders (PTLD) are rare immunosuppression complications affecting 5% of transplant patients. Isolated central nervous system (CNS)-PTLD without nodal or extra-nodal organ involvement is rarely reported and is difficult to diagnose due to the non-specific clinical manifestations and imaging features overlapping with other common CNS lesions. Case presentation: We present a case of a 72-year-old female subjected to a renal transplant 11 years ago with progressively worsening headaches and confusion. Imaging revealed vasogenic edema in the left frontal and bilateral temporal lobes. She was subjected to a craniotomy and excisional biopsy to obtain tissue for diagnostic and therapeutic interventions. Pathology examination showed atypical EBV-positive lymphoplasmacytic infiltrate, consistent with Polymorphic type PTLD. Conclusions: Patients diagnosed with PTLD need to have close monitoring of immunosuppressive medications while in the hospital. Early diagnosis is essential for patient survival with PTLD, as their health can deteriorate fast.
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spelling pubmed-97392152022-12-11 Post-Transplant Lymphoproliferative Disorder: A Rare Case of CNS Involvement following Renal Transplant Feindt, Austin Lara-Velazquez, Montserrat Alkhasawneh, Ahmad Rao, Dinesh Makary, Raafat Dombrowski, Keith Tavanaiepour, Daryoush Rahmathulla, Gazanfar J Clin Med Brief Report Background: Post-transplant lymphoproliferative disorders (PTLD) are rare immunosuppression complications affecting 5% of transplant patients. Isolated central nervous system (CNS)-PTLD without nodal or extra-nodal organ involvement is rarely reported and is difficult to diagnose due to the non-specific clinical manifestations and imaging features overlapping with other common CNS lesions. Case presentation: We present a case of a 72-year-old female subjected to a renal transplant 11 years ago with progressively worsening headaches and confusion. Imaging revealed vasogenic edema in the left frontal and bilateral temporal lobes. She was subjected to a craniotomy and excisional biopsy to obtain tissue for diagnostic and therapeutic interventions. Pathology examination showed atypical EBV-positive lymphoplasmacytic infiltrate, consistent with Polymorphic type PTLD. Conclusions: Patients diagnosed with PTLD need to have close monitoring of immunosuppressive medications while in the hospital. Early diagnosis is essential for patient survival with PTLD, as their health can deteriorate fast. MDPI 2022-11-29 /pmc/articles/PMC9739215/ /pubmed/36498633 http://dx.doi.org/10.3390/jcm11237058 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Feindt, Austin
Lara-Velazquez, Montserrat
Alkhasawneh, Ahmad
Rao, Dinesh
Makary, Raafat
Dombrowski, Keith
Tavanaiepour, Daryoush
Rahmathulla, Gazanfar
Post-Transplant Lymphoproliferative Disorder: A Rare Case of CNS Involvement following Renal Transplant
title Post-Transplant Lymphoproliferative Disorder: A Rare Case of CNS Involvement following Renal Transplant
title_full Post-Transplant Lymphoproliferative Disorder: A Rare Case of CNS Involvement following Renal Transplant
title_fullStr Post-Transplant Lymphoproliferative Disorder: A Rare Case of CNS Involvement following Renal Transplant
title_full_unstemmed Post-Transplant Lymphoproliferative Disorder: A Rare Case of CNS Involvement following Renal Transplant
title_short Post-Transplant Lymphoproliferative Disorder: A Rare Case of CNS Involvement following Renal Transplant
title_sort post-transplant lymphoproliferative disorder: a rare case of cns involvement following renal transplant
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739215/
https://www.ncbi.nlm.nih.gov/pubmed/36498633
http://dx.doi.org/10.3390/jcm11237058
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