Cargando…

A Review of the Effects of Puerarin on Glucose and Lipid Metabolism in Metabolic Syndrome: Mechanisms and Opportunities

Chronic diseases, including metabolic syndrome related to sugar and lipid metabolic disorders, are the leading causes of premature death around the world. Novel treatment strategies without undesirable effects are urgently needed. As a natural functional ingredient, puerarin is a promising alternati...

Descripción completa

Detalles Bibliográficos
Autores principales: Jing, Xiaoxuan, Zhou, Jingxuan, Zhang, Nanhai, Zhao, Liang, Wang, Shiran, Zhang, Liebing, Zhou, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739247/
https://www.ncbi.nlm.nih.gov/pubmed/36496749
http://dx.doi.org/10.3390/foods11233941
_version_ 1784847757930921984
author Jing, Xiaoxuan
Zhou, Jingxuan
Zhang, Nanhai
Zhao, Liang
Wang, Shiran
Zhang, Liebing
Zhou, Feng
author_facet Jing, Xiaoxuan
Zhou, Jingxuan
Zhang, Nanhai
Zhao, Liang
Wang, Shiran
Zhang, Liebing
Zhou, Feng
author_sort Jing, Xiaoxuan
collection PubMed
description Chronic diseases, including metabolic syndrome related to sugar and lipid metabolic disorders, are the leading causes of premature death around the world. Novel treatment strategies without undesirable effects are urgently needed. As a natural functional ingredient, puerarin is a promising alternative for the treatment of sugar and lipid metabolic disorders. However, the applications of puerarin are limited due to its poor solubility and short half-life. Various drug delivery systems have been investigated to improve the bioavailability of puerarin. This review summarizes the mechanisms involved in the beneficial action of puerarin: suppressing the release of glucose and FFA; regulating the transport of glucose and fatty acids; acting on the PI3K–Akt and AMPK signaling pathways to decrease the synthesis of glucose and fatty acids; acting on the PPAR signaling pathway to promote β-oxidation; and improving insulin secretion and sensitivity. In addition, the preparation technologies used to improve the bioavailability of puerarin are also summarized in this review, in the hope of helping to promote the application of puerarin.
format Online
Article
Text
id pubmed-9739247
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97392472022-12-11 A Review of the Effects of Puerarin on Glucose and Lipid Metabolism in Metabolic Syndrome: Mechanisms and Opportunities Jing, Xiaoxuan Zhou, Jingxuan Zhang, Nanhai Zhao, Liang Wang, Shiran Zhang, Liebing Zhou, Feng Foods Review Chronic diseases, including metabolic syndrome related to sugar and lipid metabolic disorders, are the leading causes of premature death around the world. Novel treatment strategies without undesirable effects are urgently needed. As a natural functional ingredient, puerarin is a promising alternative for the treatment of sugar and lipid metabolic disorders. However, the applications of puerarin are limited due to its poor solubility and short half-life. Various drug delivery systems have been investigated to improve the bioavailability of puerarin. This review summarizes the mechanisms involved in the beneficial action of puerarin: suppressing the release of glucose and FFA; regulating the transport of glucose and fatty acids; acting on the PI3K–Akt and AMPK signaling pathways to decrease the synthesis of glucose and fatty acids; acting on the PPAR signaling pathway to promote β-oxidation; and improving insulin secretion and sensitivity. In addition, the preparation technologies used to improve the bioavailability of puerarin are also summarized in this review, in the hope of helping to promote the application of puerarin. MDPI 2022-12-06 /pmc/articles/PMC9739247/ /pubmed/36496749 http://dx.doi.org/10.3390/foods11233941 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jing, Xiaoxuan
Zhou, Jingxuan
Zhang, Nanhai
Zhao, Liang
Wang, Shiran
Zhang, Liebing
Zhou, Feng
A Review of the Effects of Puerarin on Glucose and Lipid Metabolism in Metabolic Syndrome: Mechanisms and Opportunities
title A Review of the Effects of Puerarin on Glucose and Lipid Metabolism in Metabolic Syndrome: Mechanisms and Opportunities
title_full A Review of the Effects of Puerarin on Glucose and Lipid Metabolism in Metabolic Syndrome: Mechanisms and Opportunities
title_fullStr A Review of the Effects of Puerarin on Glucose and Lipid Metabolism in Metabolic Syndrome: Mechanisms and Opportunities
title_full_unstemmed A Review of the Effects of Puerarin on Glucose and Lipid Metabolism in Metabolic Syndrome: Mechanisms and Opportunities
title_short A Review of the Effects of Puerarin on Glucose and Lipid Metabolism in Metabolic Syndrome: Mechanisms and Opportunities
title_sort review of the effects of puerarin on glucose and lipid metabolism in metabolic syndrome: mechanisms and opportunities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739247/
https://www.ncbi.nlm.nih.gov/pubmed/36496749
http://dx.doi.org/10.3390/foods11233941
work_keys_str_mv AT jingxiaoxuan areviewoftheeffectsofpuerarinonglucoseandlipidmetabolisminmetabolicsyndromemechanismsandopportunities
AT zhoujingxuan areviewoftheeffectsofpuerarinonglucoseandlipidmetabolisminmetabolicsyndromemechanismsandopportunities
AT zhangnanhai areviewoftheeffectsofpuerarinonglucoseandlipidmetabolisminmetabolicsyndromemechanismsandopportunities
AT zhaoliang areviewoftheeffectsofpuerarinonglucoseandlipidmetabolisminmetabolicsyndromemechanismsandopportunities
AT wangshiran areviewoftheeffectsofpuerarinonglucoseandlipidmetabolisminmetabolicsyndromemechanismsandopportunities
AT zhangliebing areviewoftheeffectsofpuerarinonglucoseandlipidmetabolisminmetabolicsyndromemechanismsandopportunities
AT zhoufeng areviewoftheeffectsofpuerarinonglucoseandlipidmetabolisminmetabolicsyndromemechanismsandopportunities
AT jingxiaoxuan reviewoftheeffectsofpuerarinonglucoseandlipidmetabolisminmetabolicsyndromemechanismsandopportunities
AT zhoujingxuan reviewoftheeffectsofpuerarinonglucoseandlipidmetabolisminmetabolicsyndromemechanismsandopportunities
AT zhangnanhai reviewoftheeffectsofpuerarinonglucoseandlipidmetabolisminmetabolicsyndromemechanismsandopportunities
AT zhaoliang reviewoftheeffectsofpuerarinonglucoseandlipidmetabolisminmetabolicsyndromemechanismsandopportunities
AT wangshiran reviewoftheeffectsofpuerarinonglucoseandlipidmetabolisminmetabolicsyndromemechanismsandopportunities
AT zhangliebing reviewoftheeffectsofpuerarinonglucoseandlipidmetabolisminmetabolicsyndromemechanismsandopportunities
AT zhoufeng reviewoftheeffectsofpuerarinonglucoseandlipidmetabolisminmetabolicsyndromemechanismsandopportunities