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Comprehensive Multimorbidity Patterns in Older Patients Are Associated with Quality Indicators of Medication—MoPIM Cohort Study

Multimorbidity is increasing and poses a challenge to the clinical management of patients with multiple conditions and drug prescriptions. The objectives of this work are to evaluate if multimorbidity patterns are associated with quality indicators of medication: potentially inappropriate prescribin...

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Autores principales: Lleal, Marina, Baré, Marisa, Ortonobes, Sara, Sevilla-Sánchez, Daniel, Jordana, Rosa, Herranz, Susana, Gorgas, Maria Queralt, Espaulella-Ferrer, Mariona, Arellano, Marta, de Antonio, Marta, Nazco, Gloria Julia, Hernández-Luis, Rubén
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739326/
https://www.ncbi.nlm.nih.gov/pubmed/36497976
http://dx.doi.org/10.3390/ijerph192315902
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author Lleal, Marina
Baré, Marisa
Ortonobes, Sara
Sevilla-Sánchez, Daniel
Jordana, Rosa
Herranz, Susana
Gorgas, Maria Queralt
Espaulella-Ferrer, Mariona
Arellano, Marta
de Antonio, Marta
Nazco, Gloria Julia
Hernández-Luis, Rubén
author_facet Lleal, Marina
Baré, Marisa
Ortonobes, Sara
Sevilla-Sánchez, Daniel
Jordana, Rosa
Herranz, Susana
Gorgas, Maria Queralt
Espaulella-Ferrer, Mariona
Arellano, Marta
de Antonio, Marta
Nazco, Gloria Julia
Hernández-Luis, Rubén
author_sort Lleal, Marina
collection PubMed
description Multimorbidity is increasing and poses a challenge to the clinical management of patients with multiple conditions and drug prescriptions. The objectives of this work are to evaluate if multimorbidity patterns are associated with quality indicators of medication: potentially inappropriate prescribing (PIP) or adverse drug reactions (ADRs). A multicentre prospective cohort study was conducted including 740 older (≥65 years) patients hospitalised due to chronic pathology exacerbation. Sociodemographic, clinical and medication related variables (polypharmacy, PIP according to STOPP/START criteria, ADRs) were collected. Bivariate analyses were performed comparing previously identified multimorbidity clusters (osteoarticular, psychogeriatric, minor chronic disease, cardiorespiratory) to presence, number or specific types of PIP or ADRs. Significant associations were found in all clusters. The osteoarticular cluster presented the highest prevalence of PIP (94.9%) and ADRs (48.2%), mostly related to anxiolytics and antihypertensives, followed by the minor chronic disease cluster, associated with ADRs caused by antihypertensives and insulin. The psychogeriatric cluster presented PIP and ADRs of neuroleptics and the cardiorespiratory cluster indicators were better overall. In conclusion, the associations that were found reinforce the existence of multimorbidity patterns and support specific medication review actions according to each patient profile. Thus, determining the relationship between multimorbidity profiles and quality indicators of medication could help optimise healthcare processes. Trial registration number: NCT02830425.
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spelling pubmed-97393262022-12-11 Comprehensive Multimorbidity Patterns in Older Patients Are Associated with Quality Indicators of Medication—MoPIM Cohort Study Lleal, Marina Baré, Marisa Ortonobes, Sara Sevilla-Sánchez, Daniel Jordana, Rosa Herranz, Susana Gorgas, Maria Queralt Espaulella-Ferrer, Mariona Arellano, Marta de Antonio, Marta Nazco, Gloria Julia Hernández-Luis, Rubén Int J Environ Res Public Health Article Multimorbidity is increasing and poses a challenge to the clinical management of patients with multiple conditions and drug prescriptions. The objectives of this work are to evaluate if multimorbidity patterns are associated with quality indicators of medication: potentially inappropriate prescribing (PIP) or adverse drug reactions (ADRs). A multicentre prospective cohort study was conducted including 740 older (≥65 years) patients hospitalised due to chronic pathology exacerbation. Sociodemographic, clinical and medication related variables (polypharmacy, PIP according to STOPP/START criteria, ADRs) were collected. Bivariate analyses were performed comparing previously identified multimorbidity clusters (osteoarticular, psychogeriatric, minor chronic disease, cardiorespiratory) to presence, number or specific types of PIP or ADRs. Significant associations were found in all clusters. The osteoarticular cluster presented the highest prevalence of PIP (94.9%) and ADRs (48.2%), mostly related to anxiolytics and antihypertensives, followed by the minor chronic disease cluster, associated with ADRs caused by antihypertensives and insulin. The psychogeriatric cluster presented PIP and ADRs of neuroleptics and the cardiorespiratory cluster indicators were better overall. In conclusion, the associations that were found reinforce the existence of multimorbidity patterns and support specific medication review actions according to each patient profile. Thus, determining the relationship between multimorbidity profiles and quality indicators of medication could help optimise healthcare processes. Trial registration number: NCT02830425. MDPI 2022-11-29 /pmc/articles/PMC9739326/ /pubmed/36497976 http://dx.doi.org/10.3390/ijerph192315902 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lleal, Marina
Baré, Marisa
Ortonobes, Sara
Sevilla-Sánchez, Daniel
Jordana, Rosa
Herranz, Susana
Gorgas, Maria Queralt
Espaulella-Ferrer, Mariona
Arellano, Marta
de Antonio, Marta
Nazco, Gloria Julia
Hernández-Luis, Rubén
Comprehensive Multimorbidity Patterns in Older Patients Are Associated with Quality Indicators of Medication—MoPIM Cohort Study
title Comprehensive Multimorbidity Patterns in Older Patients Are Associated with Quality Indicators of Medication—MoPIM Cohort Study
title_full Comprehensive Multimorbidity Patterns in Older Patients Are Associated with Quality Indicators of Medication—MoPIM Cohort Study
title_fullStr Comprehensive Multimorbidity Patterns in Older Patients Are Associated with Quality Indicators of Medication—MoPIM Cohort Study
title_full_unstemmed Comprehensive Multimorbidity Patterns in Older Patients Are Associated with Quality Indicators of Medication—MoPIM Cohort Study
title_short Comprehensive Multimorbidity Patterns in Older Patients Are Associated with Quality Indicators of Medication—MoPIM Cohort Study
title_sort comprehensive multimorbidity patterns in older patients are associated with quality indicators of medication—mopim cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739326/
https://www.ncbi.nlm.nih.gov/pubmed/36497976
http://dx.doi.org/10.3390/ijerph192315902
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