Cargando…

Substrate Specificity of GSDA Revealed by Cocrystal Structures and Binding Studies

In plants, guanosine deaminase (GSDA) catalyzes the deamination of guanosine for nitrogen recycling and re-utilization. We previously solved crystal structures of GSDA from Arabidopsis thaliana (AtGSDA) and identified several novel substrates for this enzyme, but the structural basis of the enzyme a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jia, Qian, Zhang, Jinbing, Zeng, Hui, Tang, Jing, Xiao, Nan, Gao, Shangfang, Li, Huanxi, Xie, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739398/ https://www.ncbi.nlm.nih.gov/pubmed/36499303 http://dx.doi.org/10.3390/ijms232314976

Ejemplares similares

Binding asymmetry and conformational studies of the AtGSDA dimer
por: Jia, Qian, et al.
Publicado: (2023)

The Crystal Structure of the Spodoptera litura Chemosensory Protein CSP8
por: Jia, Qian, et al.
Publicado: (2021)

Gene-set distance analysis (GSDA): a powerful tool for gene-set association analysis
por: Cao, Xueyuan, et al.
Publicado: (2021)

GSDA: Generative adversarial network-based semi-supervised data augmentation for ultrasound image classification
por: Liu, Zhaoshan, et al.
Publicado: (2023)

Recent Advances in Pharmaceutical Cocrystals: A Focused Review of Flavonoid Cocrystals
por: Xu, Jia, et al.
Publicado: (2023)

Characterizations and Assays of α-Glucosidase Inhibition Activity on Gallic Acid Cocrystals: Can the Cocrystals be Defined as a New Chemical Entity During Binding with the α-Glucosidase?
por: Xue, Na, et al.
Publicado: (2020)

Nonisothermal decomposition and safety parameters of HNIW/TNT cocrystal
por: Zhang, Jiao-Qiang, et al.
Publicado: (2018)

Insights into the Mechanism of Deubiquitination by JAMM Deubiquitinases from Cocrystal Structures of the Enzyme with the Substrate and Product
por: Shrestha, Rashmi K., et al.
Publicado: (2014)

Mechanosynthesis of Higher‐Order Cocrystals: Tuning Order, Functionality and Size in Cocrystal Design
por: Ng, Zi Xuan, et al.
Publicado: (2021)

Urea as a Cocrystal Former—Study of 3 Urea Based Pharmaceutical Cocrystals
por: Leng, Fucheng, et al.
Publicado: (2021)

Drug-drug cocrystals: Opportunities and challenges
por: Wang, Xiaojuan, et al.
Publicado: (2021)

Pharmaceutical Cocrystals and Their Physicochemical Properties
por: Schultheiss, Nate, et al.
Publicado: (2009)

Cocrystal Applications in Drug Delivery
por: Erxleben, Andrea
Publicado: (2020)

Imaging supermolecular interactions of the pharmaceutical-cocrystal of apigenin-nicotinamide binding with serum albumin
por: SUN, Yuting, et al.
Publicado: (2023)

Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate–peptide complex structures
por: Zoll, Sebastian, et al.
Publicado: (2014)

Improving the Physicochemical and Biopharmaceutical Properties of Active Pharmaceutical Ingredients Derived from Traditional Chinese Medicine through Cocrystal Engineering
por: Guan, Danyingzi, et al.
Publicado: (2021)

Preparation and Characterization of Carbamazepine Cocrystal in Polymer Solution
por: Zhang, Hao, et al.
Publicado: (2017)

Investigation of the solid–liquid ternary phase diagrams of 2HNIW·HMX cocrystal
por: Jia, Qian, et al.
Publicado: (2021)

Intermolecular Vibration Energy Transfer Process in Two CL-20-Based Cocrystals Theoretically Revealed by Two-Dimensional Infrared Spectra
por: Ren, Hai-Chao, et al.
Publicado: (2022)

Non-Covalent Derivatives: Cocrystals and Eutectics
por: Stoler, Emily, et al.
Publicado: (2015)

Uracil Derivatives for Halogen-Bonded Cocrystals
por: Benito, Mónica, et al.
Publicado: (2021)

Preparation and physicochemical characterization of sildenafil cocrystals
por: Sawatdee, Somchai, et al.
Publicado: (2021)

Dehydroepiandrosterone Cocrystals with Improved Solubility and Bioavailability
por: Jiang, Yihua, et al.
Publicado: (2022)

Conformational Trimorphism in an Ionic Cocrystal of Hesperetin
por: Jin, Shasha, et al.
Publicado: (2022)

The Cocrystal of Ubiquinol: Improved Stability and Bioavailability
por: Zhang, Qi, et al.
Publicado: (2023)

Pharmaceutical Cocrystal of Piroxicam: Design, Formulation and Evaluation
por: Panzade, Prabhakar, et al.
Publicado: (2017)

Evaluating the Energetic Driving Force for Cocrystal Formation
por: Taylor, Christopher R., et al.
Publicado: (2017)

Cobaloximes as Building Blocks in Halogen-Bonded Cocrystals
por: Bedeković, Nikola, et al.
Publicado: (2020)

Isonicotinamide-Based Compounds: From Cocrystal to Polymer
por: Sánchez-Férez, Francisco, et al.
Publicado: (2019)

Two models to estimate the density of organic cocrystals
por: Zhou, Jun-Hong, et al.
Publicado: (2021)

Isostructural cocrystals of metaxalone with improved dissolution characteristics
por: Gohel, Sunil Kumar, et al.
Publicado: (2021)

Cocrystal of phloretin with isoniazid: preparation, characterization, and evaluation
por: Lu, Zhongyu, et al.
Publicado: (2023)

Cocrystals Enhance Biopharmaceutical and Antimicrobial Properties of Norfloxacin
por: Gomes, Samantha Nascimento, et al.
Publicado: (2023)

Insight into the Formation of Cocrystal and Salt of Tenoxicam from the Isomer and Conformation
por: Xie, Yifei, et al.
Publicado: (2022)

Preparation of quercetin–nicotinamide cocrystals and their evaluation under in vivo and in vitro conditions
por: Wu, Na, et al.
Publicado: (2020)

Molecular Cocrystals with Hydrogen-Bonded Polymeric Structures and Polarized Luminescence
por: Zhao, Jing-Yi, et al.
Publicado: (2022)

Cocrystal Prediction of Bexarotene by Graph Convolution Network and Bioavailability Improvement
por: Xiao, Fu, et al.
Publicado: (2022)

Investigation of possible solubility and dissolution advantages of cocrystals, I: Aqueous solubility and dissolution rates of ketoconazole and its cocrystals as functions of pH
por: Vasoya, Jaydip M., et al.
Publicado: (2019)

Selecting for Altered Substrate Specificity Reveals the Evolutionary Flexibilityof ATP-Binding Cassette Transporters
por: Srikant, Sriram, et al.
Publicado: (2020)

Continuous engineering of nano-cocrystals for medical and energetic applications
por: Spitzer, D., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_4dbnb6eiuhn4i77rot8qvie9q3