Divergent Molecular and Cellular Responses to Low and High-Dose Ionizing Radiation

Cancer risk after ionizing radiation (IR) is assumed to be linear with the dose; however, for low doses, definite evidence is lacking. Here, using temporal multi-omic systems analyses after a low (LD; 0.1 Gy) or a high (HD; 1 Gy) dose of X-rays, we show that, although the DNA damage response (DDR) d...

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Detalles Bibliográficos
Autores principales: Sampadi, Bharath, Vermeulen, Sylvia, Mišovic, Branislav, Boei, Jan J., Batth, Tanveer S., Chang, Jer-Gung, Paulsen, Michelle T., Magnuson, Brian, Schimmel, Joost, Kool, Hanneke, Olie, Cyriel S., Everts, Bart, Vertegaal, Alfred C. O., Olsen, Jesper V., Ljungman, Mats, Jeggo, Penny A., Mullenders, Leon H. F., Vrieling, Harry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739411/
https://www.ncbi.nlm.nih.gov/pubmed/36497055
http://dx.doi.org/10.3390/cells11233794

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