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Evaluation of a Dietary Supplementation Combining Protein and a Pomegranate Extract in Older People: A Safety Study

Malnutrition is a highly prevalent condition in older adults. It is associated with low muscle mass and function and increased occurrence of health problems. Maintaining an adequate nutritional status as well as a sufficient nutrient intake in older people is therefore essential to address this publ...

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Autores principales: Dormal, Valérie, Pachikian, Barbara, Debock, Elena, Buchet, Marine, Copine, Sylvie, Deldicque, Louise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739468/
https://www.ncbi.nlm.nih.gov/pubmed/36501211
http://dx.doi.org/10.3390/nu14235182
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author Dormal, Valérie
Pachikian, Barbara
Debock, Elena
Buchet, Marine
Copine, Sylvie
Deldicque, Louise
author_facet Dormal, Valérie
Pachikian, Barbara
Debock, Elena
Buchet, Marine
Copine, Sylvie
Deldicque, Louise
author_sort Dormal, Valérie
collection PubMed
description Malnutrition is a highly prevalent condition in older adults. It is associated with low muscle mass and function and increased occurrence of health problems. Maintaining an adequate nutritional status as well as a sufficient nutrient intake in older people is therefore essential to address this public health problem. For this purpose, protein supplementation is known to prevent the loss of muscle mass during aging, and the consumption of various pomegranate extracts induces numerous health benefits, mainly through their antioxidant properties. However, to our knowledge, no study has to date investigated the impact of their combination on the level of malnutrition in older people. The objective of this preliminary study was thus to evaluate the safety of a combination of protein and a pomegranate extract in healthy subjects aged 65 years or more during a 21-day supplementation period. Thirty older participants were randomly assigned to receive protein and a pomegranate extract (Test group) or protein and maltodextrin (Control group) during a 21-day intervention period. The primary outcomes were the safety and tolerability of the supplementation defined as the occurrence of adverse events, and additional secondary outcomes included physical examination and hematological and biochemical parameters. No serious adverse events were reported in any group. Changes in physical, hematological, and biochemical parameters between the initial screening and the end of the study were equivalent in both groups, except for glutamate-pyruvate transaminase (GPT) and prealbumin, for which a decrease was observed only in the Test group. Our initial findings support the safety of the combination of protein and a pomegranate extract in healthy elderly people. Future clinical trials on a larger sample and a longer period are needed to determine the efficacy of this combination.
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spelling pubmed-97394682022-12-11 Evaluation of a Dietary Supplementation Combining Protein and a Pomegranate Extract in Older People: A Safety Study Dormal, Valérie Pachikian, Barbara Debock, Elena Buchet, Marine Copine, Sylvie Deldicque, Louise Nutrients Article Malnutrition is a highly prevalent condition in older adults. It is associated with low muscle mass and function and increased occurrence of health problems. Maintaining an adequate nutritional status as well as a sufficient nutrient intake in older people is therefore essential to address this public health problem. For this purpose, protein supplementation is known to prevent the loss of muscle mass during aging, and the consumption of various pomegranate extracts induces numerous health benefits, mainly through their antioxidant properties. However, to our knowledge, no study has to date investigated the impact of their combination on the level of malnutrition in older people. The objective of this preliminary study was thus to evaluate the safety of a combination of protein and a pomegranate extract in healthy subjects aged 65 years or more during a 21-day supplementation period. Thirty older participants were randomly assigned to receive protein and a pomegranate extract (Test group) or protein and maltodextrin (Control group) during a 21-day intervention period. The primary outcomes were the safety and tolerability of the supplementation defined as the occurrence of adverse events, and additional secondary outcomes included physical examination and hematological and biochemical parameters. No serious adverse events were reported in any group. Changes in physical, hematological, and biochemical parameters between the initial screening and the end of the study were equivalent in both groups, except for glutamate-pyruvate transaminase (GPT) and prealbumin, for which a decrease was observed only in the Test group. Our initial findings support the safety of the combination of protein and a pomegranate extract in healthy elderly people. Future clinical trials on a larger sample and a longer period are needed to determine the efficacy of this combination. MDPI 2022-12-06 /pmc/articles/PMC9739468/ /pubmed/36501211 http://dx.doi.org/10.3390/nu14235182 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dormal, Valérie
Pachikian, Barbara
Debock, Elena
Buchet, Marine
Copine, Sylvie
Deldicque, Louise
Evaluation of a Dietary Supplementation Combining Protein and a Pomegranate Extract in Older People: A Safety Study
title Evaluation of a Dietary Supplementation Combining Protein and a Pomegranate Extract in Older People: A Safety Study
title_full Evaluation of a Dietary Supplementation Combining Protein and a Pomegranate Extract in Older People: A Safety Study
title_fullStr Evaluation of a Dietary Supplementation Combining Protein and a Pomegranate Extract in Older People: A Safety Study
title_full_unstemmed Evaluation of a Dietary Supplementation Combining Protein and a Pomegranate Extract in Older People: A Safety Study
title_short Evaluation of a Dietary Supplementation Combining Protein and a Pomegranate Extract in Older People: A Safety Study
title_sort evaluation of a dietary supplementation combining protein and a pomegranate extract in older people: a safety study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739468/
https://www.ncbi.nlm.nih.gov/pubmed/36501211
http://dx.doi.org/10.3390/nu14235182
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