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Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet–Fed Mice

Nonalcoholic fatty liver disease (NAFLD) is an emerging worldwide health concern. The disease may involve immune cells including T cells, but little is known about the role(s) of the innate-like T cells in the liver. Furthermore, the most abundant innate-like T cells in the human liver are mucosal-a...

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Autores principales: Kishi, Haruka, Usui, Isao, Jojima, Teruo, Fujisaka, Shiho, Wakamatsu, Sho, Mizunuma-Inoue, Yuiko, Niitani, Takafumi, Sakurai, Shintaro, Iijima, Toshie, Tomaru, Takuya, Tobe, Kazuyuki, Aso, Yoshimasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739562/
https://www.ncbi.nlm.nih.gov/pubmed/36499635
http://dx.doi.org/10.3390/ijms232315309
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author Kishi, Haruka
Usui, Isao
Jojima, Teruo
Fujisaka, Shiho
Wakamatsu, Sho
Mizunuma-Inoue, Yuiko
Niitani, Takafumi
Sakurai, Shintaro
Iijima, Toshie
Tomaru, Takuya
Tobe, Kazuyuki
Aso, Yoshimasa
author_facet Kishi, Haruka
Usui, Isao
Jojima, Teruo
Fujisaka, Shiho
Wakamatsu, Sho
Mizunuma-Inoue, Yuiko
Niitani, Takafumi
Sakurai, Shintaro
Iijima, Toshie
Tomaru, Takuya
Tobe, Kazuyuki
Aso, Yoshimasa
author_sort Kishi, Haruka
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) is an emerging worldwide health concern. The disease may involve immune cells including T cells, but little is known about the role(s) of the innate-like T cells in the liver. Furthermore, the most abundant innate-like T cells in the human liver are mucosal-associated invariant T (MAIT) cells, but the involvement of MAIT cells in NAFLD remains largely unexplored because of their paucity in mice. In this study, we used a novel mouse line, Vα19, in which the number of MAIT cells is equivalent to or greater than that in humans. Compared with the control mice, Vα19 mice fed a high-fat diet (HFD) exhibited a reduction in lipid accumulation, NAFLD activity score, and transcripts relevant to lipogenesis. In addition, serum triglyceride and non-esterified fatty acids were lower in Vα19 mice fed normal chow or HFD. In contrast, the Vα19 mice showed little or no change in glucose tolerance, insulin sensitivity, inflammation in adipose tissues, or intestinal permeability compared with the controls, irrespective of diet. These results suggest that the presence of MAIT cells is associated with reduced lipogenesis and lipid accumulation in the liver; however, further studies are needed to clarify the role of MAIT cells in hepatic lipid metabolism.
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spelling pubmed-97395622022-12-11 Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet–Fed Mice Kishi, Haruka Usui, Isao Jojima, Teruo Fujisaka, Shiho Wakamatsu, Sho Mizunuma-Inoue, Yuiko Niitani, Takafumi Sakurai, Shintaro Iijima, Toshie Tomaru, Takuya Tobe, Kazuyuki Aso, Yoshimasa Int J Mol Sci Article Nonalcoholic fatty liver disease (NAFLD) is an emerging worldwide health concern. The disease may involve immune cells including T cells, but little is known about the role(s) of the innate-like T cells in the liver. Furthermore, the most abundant innate-like T cells in the human liver are mucosal-associated invariant T (MAIT) cells, but the involvement of MAIT cells in NAFLD remains largely unexplored because of their paucity in mice. In this study, we used a novel mouse line, Vα19, in which the number of MAIT cells is equivalent to or greater than that in humans. Compared with the control mice, Vα19 mice fed a high-fat diet (HFD) exhibited a reduction in lipid accumulation, NAFLD activity score, and transcripts relevant to lipogenesis. In addition, serum triglyceride and non-esterified fatty acids were lower in Vα19 mice fed normal chow or HFD. In contrast, the Vα19 mice showed little or no change in glucose tolerance, insulin sensitivity, inflammation in adipose tissues, or intestinal permeability compared with the controls, irrespective of diet. These results suggest that the presence of MAIT cells is associated with reduced lipogenesis and lipid accumulation in the liver; however, further studies are needed to clarify the role of MAIT cells in hepatic lipid metabolism. MDPI 2022-12-04 /pmc/articles/PMC9739562/ /pubmed/36499635 http://dx.doi.org/10.3390/ijms232315309 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kishi, Haruka
Usui, Isao
Jojima, Teruo
Fujisaka, Shiho
Wakamatsu, Sho
Mizunuma-Inoue, Yuiko
Niitani, Takafumi
Sakurai, Shintaro
Iijima, Toshie
Tomaru, Takuya
Tobe, Kazuyuki
Aso, Yoshimasa
Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet–Fed Mice
title Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet–Fed Mice
title_full Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet–Fed Mice
title_fullStr Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet–Fed Mice
title_full_unstemmed Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet–Fed Mice
title_short Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet–Fed Mice
title_sort increased number of mucosal-associated invariant t cells is associated with the inhibition of nonalcoholic fatty liver disease in high fat diet–fed mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739562/
https://www.ncbi.nlm.nih.gov/pubmed/36499635
http://dx.doi.org/10.3390/ijms232315309
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