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Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet–Fed Mice
Nonalcoholic fatty liver disease (NAFLD) is an emerging worldwide health concern. The disease may involve immune cells including T cells, but little is known about the role(s) of the innate-like T cells in the liver. Furthermore, the most abundant innate-like T cells in the human liver are mucosal-a...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739562/ https://www.ncbi.nlm.nih.gov/pubmed/36499635 http://dx.doi.org/10.3390/ijms232315309 |
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author | Kishi, Haruka Usui, Isao Jojima, Teruo Fujisaka, Shiho Wakamatsu, Sho Mizunuma-Inoue, Yuiko Niitani, Takafumi Sakurai, Shintaro Iijima, Toshie Tomaru, Takuya Tobe, Kazuyuki Aso, Yoshimasa |
author_facet | Kishi, Haruka Usui, Isao Jojima, Teruo Fujisaka, Shiho Wakamatsu, Sho Mizunuma-Inoue, Yuiko Niitani, Takafumi Sakurai, Shintaro Iijima, Toshie Tomaru, Takuya Tobe, Kazuyuki Aso, Yoshimasa |
author_sort | Kishi, Haruka |
collection | PubMed |
description | Nonalcoholic fatty liver disease (NAFLD) is an emerging worldwide health concern. The disease may involve immune cells including T cells, but little is known about the role(s) of the innate-like T cells in the liver. Furthermore, the most abundant innate-like T cells in the human liver are mucosal-associated invariant T (MAIT) cells, but the involvement of MAIT cells in NAFLD remains largely unexplored because of their paucity in mice. In this study, we used a novel mouse line, Vα19, in which the number of MAIT cells is equivalent to or greater than that in humans. Compared with the control mice, Vα19 mice fed a high-fat diet (HFD) exhibited a reduction in lipid accumulation, NAFLD activity score, and transcripts relevant to lipogenesis. In addition, serum triglyceride and non-esterified fatty acids were lower in Vα19 mice fed normal chow or HFD. In contrast, the Vα19 mice showed little or no change in glucose tolerance, insulin sensitivity, inflammation in adipose tissues, or intestinal permeability compared with the controls, irrespective of diet. These results suggest that the presence of MAIT cells is associated with reduced lipogenesis and lipid accumulation in the liver; however, further studies are needed to clarify the role of MAIT cells in hepatic lipid metabolism. |
format | Online Article Text |
id | pubmed-9739562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97395622022-12-11 Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet–Fed Mice Kishi, Haruka Usui, Isao Jojima, Teruo Fujisaka, Shiho Wakamatsu, Sho Mizunuma-Inoue, Yuiko Niitani, Takafumi Sakurai, Shintaro Iijima, Toshie Tomaru, Takuya Tobe, Kazuyuki Aso, Yoshimasa Int J Mol Sci Article Nonalcoholic fatty liver disease (NAFLD) is an emerging worldwide health concern. The disease may involve immune cells including T cells, but little is known about the role(s) of the innate-like T cells in the liver. Furthermore, the most abundant innate-like T cells in the human liver are mucosal-associated invariant T (MAIT) cells, but the involvement of MAIT cells in NAFLD remains largely unexplored because of their paucity in mice. In this study, we used a novel mouse line, Vα19, in which the number of MAIT cells is equivalent to or greater than that in humans. Compared with the control mice, Vα19 mice fed a high-fat diet (HFD) exhibited a reduction in lipid accumulation, NAFLD activity score, and transcripts relevant to lipogenesis. In addition, serum triglyceride and non-esterified fatty acids were lower in Vα19 mice fed normal chow or HFD. In contrast, the Vα19 mice showed little or no change in glucose tolerance, insulin sensitivity, inflammation in adipose tissues, or intestinal permeability compared with the controls, irrespective of diet. These results suggest that the presence of MAIT cells is associated with reduced lipogenesis and lipid accumulation in the liver; however, further studies are needed to clarify the role of MAIT cells in hepatic lipid metabolism. MDPI 2022-12-04 /pmc/articles/PMC9739562/ /pubmed/36499635 http://dx.doi.org/10.3390/ijms232315309 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kishi, Haruka Usui, Isao Jojima, Teruo Fujisaka, Shiho Wakamatsu, Sho Mizunuma-Inoue, Yuiko Niitani, Takafumi Sakurai, Shintaro Iijima, Toshie Tomaru, Takuya Tobe, Kazuyuki Aso, Yoshimasa Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet–Fed Mice |
title | Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet–Fed Mice |
title_full | Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet–Fed Mice |
title_fullStr | Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet–Fed Mice |
title_full_unstemmed | Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet–Fed Mice |
title_short | Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet–Fed Mice |
title_sort | increased number of mucosal-associated invariant t cells is associated with the inhibition of nonalcoholic fatty liver disease in high fat diet–fed mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739562/ https://www.ncbi.nlm.nih.gov/pubmed/36499635 http://dx.doi.org/10.3390/ijms232315309 |
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