Cargando…

The Presence of Ankylosing Spondylitis and the Incidence of Subsequent External Eye Diseases: A Population-Based Cohort Study

We aimed to survey the risk of external eye diseases in those with ankylosing spondylitis (AS) via the National Health Insurance Research Database (NHIRD) in Taiwan. We conducted a retrospective cohort study, and subjects diagnosed with AS were selected from the NHIRD. Then, the AS patients were mat...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Chia-Yi, Chen, Hung-Chi, Huang, Jing-Yang, Yen, Chieh-Hung, Hwang, Yih-Shiou, Chang, Chao-Kai, Yang, Shun-Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739666/
https://www.ncbi.nlm.nih.gov/pubmed/36498369
http://dx.doi.org/10.3390/ijerph192316296
_version_ 1784847864573198336
author Lee, Chia-Yi
Chen, Hung-Chi
Huang, Jing-Yang
Yen, Chieh-Hung
Hwang, Yih-Shiou
Chang, Chao-Kai
Yang, Shun-Fa
author_facet Lee, Chia-Yi
Chen, Hung-Chi
Huang, Jing-Yang
Yen, Chieh-Hung
Hwang, Yih-Shiou
Chang, Chao-Kai
Yang, Shun-Fa
author_sort Lee, Chia-Yi
collection PubMed
description We aimed to survey the risk of external eye diseases in those with ankylosing spondylitis (AS) via the National Health Insurance Research Database (NHIRD) in Taiwan. We conducted a retrospective cohort study, and subjects diagnosed with AS were selected from the NHIRD. Then, the AS patients were matched 1:1 by propensity-score matching (PSM) to non-AS patients, and a total of 6754 participants were included in the AS and non-AS groups. The main outcomes were regarded as the occurrence of dry eye disease (DED), superficial keratopathy and corneal ulcers. We used Cox proportional hazard regression to yield the adjusted hazard ratios (AHR) with 95% confidence intervals (CI) between the AS and non-AS groups. There were 709 and 408 external eye disease events that occurred in the AS and non-AS groups after a tracking interval of up to 17 years. The incidence of all external eye diseases was significantly higher in the AS group than the non-AS group (AHR: 1.826, 95% CI: 1.616–2.063, p < 0.0001). Additionally, the rates of DED (AHR: 1.973, 95% CI: 1.701–2.290, p < 0.0001) and superficial keratopathy (AHR: 1.593, 95% CI: 1.347–1.883, p < 0.0001) were significantly higher in the AS group than the non-AS group. In the sub-group analyses, the possibility of any external eye disease (p = 0.0030) and DED (p = 0.0386) was decreased in the older age group compared to those in the middle-aged group. In conclusion, AS is significantly correlated to subsequent external eye diseases, mainly the DED and superficial keratopathy.
format Online
Article
Text
id pubmed-9739666
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97396662022-12-11 The Presence of Ankylosing Spondylitis and the Incidence of Subsequent External Eye Diseases: A Population-Based Cohort Study Lee, Chia-Yi Chen, Hung-Chi Huang, Jing-Yang Yen, Chieh-Hung Hwang, Yih-Shiou Chang, Chao-Kai Yang, Shun-Fa Int J Environ Res Public Health Article We aimed to survey the risk of external eye diseases in those with ankylosing spondylitis (AS) via the National Health Insurance Research Database (NHIRD) in Taiwan. We conducted a retrospective cohort study, and subjects diagnosed with AS were selected from the NHIRD. Then, the AS patients were matched 1:1 by propensity-score matching (PSM) to non-AS patients, and a total of 6754 participants were included in the AS and non-AS groups. The main outcomes were regarded as the occurrence of dry eye disease (DED), superficial keratopathy and corneal ulcers. We used Cox proportional hazard regression to yield the adjusted hazard ratios (AHR) with 95% confidence intervals (CI) between the AS and non-AS groups. There were 709 and 408 external eye disease events that occurred in the AS and non-AS groups after a tracking interval of up to 17 years. The incidence of all external eye diseases was significantly higher in the AS group than the non-AS group (AHR: 1.826, 95% CI: 1.616–2.063, p < 0.0001). Additionally, the rates of DED (AHR: 1.973, 95% CI: 1.701–2.290, p < 0.0001) and superficial keratopathy (AHR: 1.593, 95% CI: 1.347–1.883, p < 0.0001) were significantly higher in the AS group than the non-AS group. In the sub-group analyses, the possibility of any external eye disease (p = 0.0030) and DED (p = 0.0386) was decreased in the older age group compared to those in the middle-aged group. In conclusion, AS is significantly correlated to subsequent external eye diseases, mainly the DED and superficial keratopathy. MDPI 2022-12-05 /pmc/articles/PMC9739666/ /pubmed/36498369 http://dx.doi.org/10.3390/ijerph192316296 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Chia-Yi
Chen, Hung-Chi
Huang, Jing-Yang
Yen, Chieh-Hung
Hwang, Yih-Shiou
Chang, Chao-Kai
Yang, Shun-Fa
The Presence of Ankylosing Spondylitis and the Incidence of Subsequent External Eye Diseases: A Population-Based Cohort Study
title The Presence of Ankylosing Spondylitis and the Incidence of Subsequent External Eye Diseases: A Population-Based Cohort Study
title_full The Presence of Ankylosing Spondylitis and the Incidence of Subsequent External Eye Diseases: A Population-Based Cohort Study
title_fullStr The Presence of Ankylosing Spondylitis and the Incidence of Subsequent External Eye Diseases: A Population-Based Cohort Study
title_full_unstemmed The Presence of Ankylosing Spondylitis and the Incidence of Subsequent External Eye Diseases: A Population-Based Cohort Study
title_short The Presence of Ankylosing Spondylitis and the Incidence of Subsequent External Eye Diseases: A Population-Based Cohort Study
title_sort presence of ankylosing spondylitis and the incidence of subsequent external eye diseases: a population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739666/
https://www.ncbi.nlm.nih.gov/pubmed/36498369
http://dx.doi.org/10.3390/ijerph192316296
work_keys_str_mv AT leechiayi thepresenceofankylosingspondylitisandtheincidenceofsubsequentexternaleyediseasesapopulationbasedcohortstudy
AT chenhungchi thepresenceofankylosingspondylitisandtheincidenceofsubsequentexternaleyediseasesapopulationbasedcohortstudy
AT huangjingyang thepresenceofankylosingspondylitisandtheincidenceofsubsequentexternaleyediseasesapopulationbasedcohortstudy
AT yenchiehhung thepresenceofankylosingspondylitisandtheincidenceofsubsequentexternaleyediseasesapopulationbasedcohortstudy
AT hwangyihshiou thepresenceofankylosingspondylitisandtheincidenceofsubsequentexternaleyediseasesapopulationbasedcohortstudy
AT changchaokai thepresenceofankylosingspondylitisandtheincidenceofsubsequentexternaleyediseasesapopulationbasedcohortstudy
AT yangshunfa thepresenceofankylosingspondylitisandtheincidenceofsubsequentexternaleyediseasesapopulationbasedcohortstudy
AT leechiayi presenceofankylosingspondylitisandtheincidenceofsubsequentexternaleyediseasesapopulationbasedcohortstudy
AT chenhungchi presenceofankylosingspondylitisandtheincidenceofsubsequentexternaleyediseasesapopulationbasedcohortstudy
AT huangjingyang presenceofankylosingspondylitisandtheincidenceofsubsequentexternaleyediseasesapopulationbasedcohortstudy
AT yenchiehhung presenceofankylosingspondylitisandtheincidenceofsubsequentexternaleyediseasesapopulationbasedcohortstudy
AT hwangyihshiou presenceofankylosingspondylitisandtheincidenceofsubsequentexternaleyediseasesapopulationbasedcohortstudy
AT changchaokai presenceofankylosingspondylitisandtheincidenceofsubsequentexternaleyediseasesapopulationbasedcohortstudy
AT yangshunfa presenceofankylosingspondylitisandtheincidenceofsubsequentexternaleyediseasesapopulationbasedcohortstudy