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The Presence of Ankylosing Spondylitis and the Incidence of Subsequent External Eye Diseases: A Population-Based Cohort Study
We aimed to survey the risk of external eye diseases in those with ankylosing spondylitis (AS) via the National Health Insurance Research Database (NHIRD) in Taiwan. We conducted a retrospective cohort study, and subjects diagnosed with AS were selected from the NHIRD. Then, the AS patients were mat...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739666/ https://www.ncbi.nlm.nih.gov/pubmed/36498369 http://dx.doi.org/10.3390/ijerph192316296 |
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author | Lee, Chia-Yi Chen, Hung-Chi Huang, Jing-Yang Yen, Chieh-Hung Hwang, Yih-Shiou Chang, Chao-Kai Yang, Shun-Fa |
author_facet | Lee, Chia-Yi Chen, Hung-Chi Huang, Jing-Yang Yen, Chieh-Hung Hwang, Yih-Shiou Chang, Chao-Kai Yang, Shun-Fa |
author_sort | Lee, Chia-Yi |
collection | PubMed |
description | We aimed to survey the risk of external eye diseases in those with ankylosing spondylitis (AS) via the National Health Insurance Research Database (NHIRD) in Taiwan. We conducted a retrospective cohort study, and subjects diagnosed with AS were selected from the NHIRD. Then, the AS patients were matched 1:1 by propensity-score matching (PSM) to non-AS patients, and a total of 6754 participants were included in the AS and non-AS groups. The main outcomes were regarded as the occurrence of dry eye disease (DED), superficial keratopathy and corneal ulcers. We used Cox proportional hazard regression to yield the adjusted hazard ratios (AHR) with 95% confidence intervals (CI) between the AS and non-AS groups. There were 709 and 408 external eye disease events that occurred in the AS and non-AS groups after a tracking interval of up to 17 years. The incidence of all external eye diseases was significantly higher in the AS group than the non-AS group (AHR: 1.826, 95% CI: 1.616–2.063, p < 0.0001). Additionally, the rates of DED (AHR: 1.973, 95% CI: 1.701–2.290, p < 0.0001) and superficial keratopathy (AHR: 1.593, 95% CI: 1.347–1.883, p < 0.0001) were significantly higher in the AS group than the non-AS group. In the sub-group analyses, the possibility of any external eye disease (p = 0.0030) and DED (p = 0.0386) was decreased in the older age group compared to those in the middle-aged group. In conclusion, AS is significantly correlated to subsequent external eye diseases, mainly the DED and superficial keratopathy. |
format | Online Article Text |
id | pubmed-9739666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97396662022-12-11 The Presence of Ankylosing Spondylitis and the Incidence of Subsequent External Eye Diseases: A Population-Based Cohort Study Lee, Chia-Yi Chen, Hung-Chi Huang, Jing-Yang Yen, Chieh-Hung Hwang, Yih-Shiou Chang, Chao-Kai Yang, Shun-Fa Int J Environ Res Public Health Article We aimed to survey the risk of external eye diseases in those with ankylosing spondylitis (AS) via the National Health Insurance Research Database (NHIRD) in Taiwan. We conducted a retrospective cohort study, and subjects diagnosed with AS were selected from the NHIRD. Then, the AS patients were matched 1:1 by propensity-score matching (PSM) to non-AS patients, and a total of 6754 participants were included in the AS and non-AS groups. The main outcomes were regarded as the occurrence of dry eye disease (DED), superficial keratopathy and corneal ulcers. We used Cox proportional hazard regression to yield the adjusted hazard ratios (AHR) with 95% confidence intervals (CI) between the AS and non-AS groups. There were 709 and 408 external eye disease events that occurred in the AS and non-AS groups after a tracking interval of up to 17 years. The incidence of all external eye diseases was significantly higher in the AS group than the non-AS group (AHR: 1.826, 95% CI: 1.616–2.063, p < 0.0001). Additionally, the rates of DED (AHR: 1.973, 95% CI: 1.701–2.290, p < 0.0001) and superficial keratopathy (AHR: 1.593, 95% CI: 1.347–1.883, p < 0.0001) were significantly higher in the AS group than the non-AS group. In the sub-group analyses, the possibility of any external eye disease (p = 0.0030) and DED (p = 0.0386) was decreased in the older age group compared to those in the middle-aged group. In conclusion, AS is significantly correlated to subsequent external eye diseases, mainly the DED and superficial keratopathy. MDPI 2022-12-05 /pmc/articles/PMC9739666/ /pubmed/36498369 http://dx.doi.org/10.3390/ijerph192316296 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Chia-Yi Chen, Hung-Chi Huang, Jing-Yang Yen, Chieh-Hung Hwang, Yih-Shiou Chang, Chao-Kai Yang, Shun-Fa The Presence of Ankylosing Spondylitis and the Incidence of Subsequent External Eye Diseases: A Population-Based Cohort Study |
title | The Presence of Ankylosing Spondylitis and the Incidence of Subsequent External Eye Diseases: A Population-Based Cohort Study |
title_full | The Presence of Ankylosing Spondylitis and the Incidence of Subsequent External Eye Diseases: A Population-Based Cohort Study |
title_fullStr | The Presence of Ankylosing Spondylitis and the Incidence of Subsequent External Eye Diseases: A Population-Based Cohort Study |
title_full_unstemmed | The Presence of Ankylosing Spondylitis and the Incidence of Subsequent External Eye Diseases: A Population-Based Cohort Study |
title_short | The Presence of Ankylosing Spondylitis and the Incidence of Subsequent External Eye Diseases: A Population-Based Cohort Study |
title_sort | presence of ankylosing spondylitis and the incidence of subsequent external eye diseases: a population-based cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739666/ https://www.ncbi.nlm.nih.gov/pubmed/36498369 http://dx.doi.org/10.3390/ijerph192316296 |
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