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VDR Regulates BNP Promoting Neurite Growth and Survival of Cochlear Spiral Ganglion Neurons through cGMP-PKG Signaling Pathway

Spiral ganglion neurons (SGNs) are important for hearing, and their peripheral and central processes connect sensory cells of the Corti organ to the central nervous system. The resulting network forms a point-to-point auditory conduction. As a cardiac hormone, brain natriuretic peptide (BNP) binds t...

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Autores principales: Zhang, Xinyu, Zhou, Ke, Tian, Keyong, Zhu, Qingwen, Liu, Wei, Liu, Zhenzhen, An, Xiaogang, Tian, Chaoyong, Li, Yao, Lu, Fei, Sun, Fei, Zha, Dingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739822/
https://www.ncbi.nlm.nih.gov/pubmed/36497006
http://dx.doi.org/10.3390/cells11233746
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author Zhang, Xinyu
Zhou, Ke
Tian, Keyong
Zhu, Qingwen
Liu, Wei
Liu, Zhenzhen
An, Xiaogang
Tian, Chaoyong
Li, Yao
Lu, Fei
Sun, Fei
Zha, Dingjun
author_facet Zhang, Xinyu
Zhou, Ke
Tian, Keyong
Zhu, Qingwen
Liu, Wei
Liu, Zhenzhen
An, Xiaogang
Tian, Chaoyong
Li, Yao
Lu, Fei
Sun, Fei
Zha, Dingjun
author_sort Zhang, Xinyu
collection PubMed
description Spiral ganglion neurons (SGNs) are important for hearing, and their peripheral and central processes connect sensory cells of the Corti organ to the central nervous system. The resulting network forms a point-to-point auditory conduction. As a cardiac hormone, brain natriuretic peptide (BNP) binds to natriuretic peptide receptor type A leading to diuresis, vasodilatation, inhibition of renin and aldosterone production, and cardiac and vascular myocyte growth. This study primarily aimed to explore the expression and function of BNP in the rat’s inner ear and elucidate its regulatory mechanism. We determined the expression and function of BNP and found that the vitamin D receptor (VDR) could upregulate the expression of BNP and enhance its function. In SGNs of the rat inner ear, BNP promotes neuron survival and prolongs neurite length through the cGMP-PKG signaling pathway, which could be regulated by VDR and provide a novel approach for neuronal regeneration therapy. To the best of our knowledge, this is the first study to report this potential transcriptional regulatory relationship and will act as a reference for research on neuronal regeneration therapy for SGNs injury.
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spelling pubmed-97398222022-12-11 VDR Regulates BNP Promoting Neurite Growth and Survival of Cochlear Spiral Ganglion Neurons through cGMP-PKG Signaling Pathway Zhang, Xinyu Zhou, Ke Tian, Keyong Zhu, Qingwen Liu, Wei Liu, Zhenzhen An, Xiaogang Tian, Chaoyong Li, Yao Lu, Fei Sun, Fei Zha, Dingjun Cells Article Spiral ganglion neurons (SGNs) are important for hearing, and their peripheral and central processes connect sensory cells of the Corti organ to the central nervous system. The resulting network forms a point-to-point auditory conduction. As a cardiac hormone, brain natriuretic peptide (BNP) binds to natriuretic peptide receptor type A leading to diuresis, vasodilatation, inhibition of renin and aldosterone production, and cardiac and vascular myocyte growth. This study primarily aimed to explore the expression and function of BNP in the rat’s inner ear and elucidate its regulatory mechanism. We determined the expression and function of BNP and found that the vitamin D receptor (VDR) could upregulate the expression of BNP and enhance its function. In SGNs of the rat inner ear, BNP promotes neuron survival and prolongs neurite length through the cGMP-PKG signaling pathway, which could be regulated by VDR and provide a novel approach for neuronal regeneration therapy. To the best of our knowledge, this is the first study to report this potential transcriptional regulatory relationship and will act as a reference for research on neuronal regeneration therapy for SGNs injury. MDPI 2022-11-23 /pmc/articles/PMC9739822/ /pubmed/36497006 http://dx.doi.org/10.3390/cells11233746 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Xinyu
Zhou, Ke
Tian, Keyong
Zhu, Qingwen
Liu, Wei
Liu, Zhenzhen
An, Xiaogang
Tian, Chaoyong
Li, Yao
Lu, Fei
Sun, Fei
Zha, Dingjun
VDR Regulates BNP Promoting Neurite Growth and Survival of Cochlear Spiral Ganglion Neurons through cGMP-PKG Signaling Pathway
title VDR Regulates BNP Promoting Neurite Growth and Survival of Cochlear Spiral Ganglion Neurons through cGMP-PKG Signaling Pathway
title_full VDR Regulates BNP Promoting Neurite Growth and Survival of Cochlear Spiral Ganglion Neurons through cGMP-PKG Signaling Pathway
title_fullStr VDR Regulates BNP Promoting Neurite Growth and Survival of Cochlear Spiral Ganglion Neurons through cGMP-PKG Signaling Pathway
title_full_unstemmed VDR Regulates BNP Promoting Neurite Growth and Survival of Cochlear Spiral Ganglion Neurons through cGMP-PKG Signaling Pathway
title_short VDR Regulates BNP Promoting Neurite Growth and Survival of Cochlear Spiral Ganglion Neurons through cGMP-PKG Signaling Pathway
title_sort vdr regulates bnp promoting neurite growth and survival of cochlear spiral ganglion neurons through cgmp-pkg signaling pathway
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739822/
https://www.ncbi.nlm.nih.gov/pubmed/36497006
http://dx.doi.org/10.3390/cells11233746
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