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In Vitro Anti-Influenza A Virus H1N1 Effect of Sesquiterpene-Rich Extracts of Carpesium abrotanoides

Due to a high content of sesquiterpenes, Carpesium abrotanoides has been investigated to fully explore its health-promoting properties. Therefore, this work aimed to assess, for the first time, the anti-influenza A virus H1N1 potential of sesquiterpene-targeted fractions of the herb derived from C....

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Autores principales: Li, Li, Yang, Shenghui, Chen, Dilu, Wu, Zhihuang, Zhang, Meijun, Yang, Fang, Qin, Li, Zhou, Xiaojiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739900/
https://www.ncbi.nlm.nih.gov/pubmed/36500406
http://dx.doi.org/10.3390/molecules27238313
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author Li, Li
Yang, Shenghui
Chen, Dilu
Wu, Zhihuang
Zhang, Meijun
Yang, Fang
Qin, Li
Zhou, Xiaojiang
author_facet Li, Li
Yang, Shenghui
Chen, Dilu
Wu, Zhihuang
Zhang, Meijun
Yang, Fang
Qin, Li
Zhou, Xiaojiang
author_sort Li, Li
collection PubMed
description Due to a high content of sesquiterpenes, Carpesium abrotanoides has been investigated to fully explore its health-promoting properties. Therefore, this work aimed to assess, for the first time, the anti-influenza A virus H1N1 potential of sesquiterpene-targeted fractions of the herb derived from C. abrotanoides. Five compounds, including four sesquiterpenes and one aldehyde, were isolated and identified from the sesquiterpene-rich extracts of C. abrotanoides (SECA), and the contents of three main sesquiterpenes in the SECA were determined. Furthermore, SECA showed a significant protective effect in the MDCK cells infected with influenza A virus (H1N1) in three different conditions: premixed administration, prophylactic administration, and therapeutic administration. SECA can significantly decrease the mRNA expressions of TLR4, MyD88, NF-κB, TNF-α, and IL-6, as well as the protein expressions of TLR4, MyD88, and NF-κB. This result suggests that SECA can resist the influenza A virus H1N1 through the TLR4/MyD88/NF-κB signal pathway.
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spelling pubmed-97399002022-12-11 In Vitro Anti-Influenza A Virus H1N1 Effect of Sesquiterpene-Rich Extracts of Carpesium abrotanoides Li, Li Yang, Shenghui Chen, Dilu Wu, Zhihuang Zhang, Meijun Yang, Fang Qin, Li Zhou, Xiaojiang Molecules Article Due to a high content of sesquiterpenes, Carpesium abrotanoides has been investigated to fully explore its health-promoting properties. Therefore, this work aimed to assess, for the first time, the anti-influenza A virus H1N1 potential of sesquiterpene-targeted fractions of the herb derived from C. abrotanoides. Five compounds, including four sesquiterpenes and one aldehyde, were isolated and identified from the sesquiterpene-rich extracts of C. abrotanoides (SECA), and the contents of three main sesquiterpenes in the SECA were determined. Furthermore, SECA showed a significant protective effect in the MDCK cells infected with influenza A virus (H1N1) in three different conditions: premixed administration, prophylactic administration, and therapeutic administration. SECA can significantly decrease the mRNA expressions of TLR4, MyD88, NF-κB, TNF-α, and IL-6, as well as the protein expressions of TLR4, MyD88, and NF-κB. This result suggests that SECA can resist the influenza A virus H1N1 through the TLR4/MyD88/NF-κB signal pathway. MDPI 2022-11-29 /pmc/articles/PMC9739900/ /pubmed/36500406 http://dx.doi.org/10.3390/molecules27238313 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Li
Yang, Shenghui
Chen, Dilu
Wu, Zhihuang
Zhang, Meijun
Yang, Fang
Qin, Li
Zhou, Xiaojiang
In Vitro Anti-Influenza A Virus H1N1 Effect of Sesquiterpene-Rich Extracts of Carpesium abrotanoides
title In Vitro Anti-Influenza A Virus H1N1 Effect of Sesquiterpene-Rich Extracts of Carpesium abrotanoides
title_full In Vitro Anti-Influenza A Virus H1N1 Effect of Sesquiterpene-Rich Extracts of Carpesium abrotanoides
title_fullStr In Vitro Anti-Influenza A Virus H1N1 Effect of Sesquiterpene-Rich Extracts of Carpesium abrotanoides
title_full_unstemmed In Vitro Anti-Influenza A Virus H1N1 Effect of Sesquiterpene-Rich Extracts of Carpesium abrotanoides
title_short In Vitro Anti-Influenza A Virus H1N1 Effect of Sesquiterpene-Rich Extracts of Carpesium abrotanoides
title_sort in vitro anti-influenza a virus h1n1 effect of sesquiterpene-rich extracts of carpesium abrotanoides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739900/
https://www.ncbi.nlm.nih.gov/pubmed/36500406
http://dx.doi.org/10.3390/molecules27238313
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