Cargando…

Outcomes and Complications of Pelvic Chondrosarcomas Treated Using Navigation Guidance and Multidisciplinary Approach: Is the Tumor Volume a Prognostic Factor?

(1) Background: Pelvic Chondrosarcomas (CS) have a poor prognosis. The grade is the most important survival predictor; other factors are periacetabular location and Dedifferentiated CS subtype. The aim of the study is to investigate a series of CS of the pelvis, to analyze the prognostic factors tha...

Descripción completa

Detalles Bibliográficos
Autores principales: Crimì, Alberto, Binitie, Odion T., Crimì, Filippo, Letson, G. Douglas, Joyce, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740033/
https://www.ncbi.nlm.nih.gov/pubmed/36498687
http://dx.doi.org/10.3390/jcm11237111
_version_ 1784847957884928000
author Crimì, Alberto
Binitie, Odion T.
Crimì, Filippo
Letson, G. Douglas
Joyce, David M.
author_facet Crimì, Alberto
Binitie, Odion T.
Crimì, Filippo
Letson, G. Douglas
Joyce, David M.
author_sort Crimì, Alberto
collection PubMed
description (1) Background: Pelvic Chondrosarcomas (CS) have a poor prognosis. The grade is the most important survival predictor; other factors are periacetabular location and Dedifferentiated CS subtype. The aim of the study is to investigate a series of CS of the pelvis, to analyze the prognostic factors that affect outcomes and to demonstrate how the use of intraoperative navigation can reduce the complications without worse outcomes. (2) Methods: Retrospective study on 35 patients (21 M, 14 F), median age at surgery 54 years (IQR 41–65), with pelvic CS, treated with hemipelvectomy under navigation guidance. (3) Results: 30 high-grade CS and 5 low-grade CS; mean follow-up 51.4 months. There was a positive linear correlation between the tumor volume and the presence of local recurrence at follow-up. The mean survival time of patients with larger chondrosarcoma volume was lower, but not significantly so. Lower MSTS score was associated with significantly lower survival time (p < 0.001). (4) Conclusion: in this series overall survival, LR and distant metastasis were comparable with recent literature, while complication rate was lower compared to similar series without the use of navigation. There was a correlation between tumor volume and local recurrence rate but not with the presence of metastasis at follow up.
format Online
Article
Text
id pubmed-9740033
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97400332022-12-11 Outcomes and Complications of Pelvic Chondrosarcomas Treated Using Navigation Guidance and Multidisciplinary Approach: Is the Tumor Volume a Prognostic Factor? Crimì, Alberto Binitie, Odion T. Crimì, Filippo Letson, G. Douglas Joyce, David M. J Clin Med Article (1) Background: Pelvic Chondrosarcomas (CS) have a poor prognosis. The grade is the most important survival predictor; other factors are periacetabular location and Dedifferentiated CS subtype. The aim of the study is to investigate a series of CS of the pelvis, to analyze the prognostic factors that affect outcomes and to demonstrate how the use of intraoperative navigation can reduce the complications without worse outcomes. (2) Methods: Retrospective study on 35 patients (21 M, 14 F), median age at surgery 54 years (IQR 41–65), with pelvic CS, treated with hemipelvectomy under navigation guidance. (3) Results: 30 high-grade CS and 5 low-grade CS; mean follow-up 51.4 months. There was a positive linear correlation between the tumor volume and the presence of local recurrence at follow-up. The mean survival time of patients with larger chondrosarcoma volume was lower, but not significantly so. Lower MSTS score was associated with significantly lower survival time (p < 0.001). (4) Conclusion: in this series overall survival, LR and distant metastasis were comparable with recent literature, while complication rate was lower compared to similar series without the use of navigation. There was a correlation between tumor volume and local recurrence rate but not with the presence of metastasis at follow up. MDPI 2022-11-30 /pmc/articles/PMC9740033/ /pubmed/36498687 http://dx.doi.org/10.3390/jcm11237111 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Crimì, Alberto
Binitie, Odion T.
Crimì, Filippo
Letson, G. Douglas
Joyce, David M.
Outcomes and Complications of Pelvic Chondrosarcomas Treated Using Navigation Guidance and Multidisciplinary Approach: Is the Tumor Volume a Prognostic Factor?
title Outcomes and Complications of Pelvic Chondrosarcomas Treated Using Navigation Guidance and Multidisciplinary Approach: Is the Tumor Volume a Prognostic Factor?
title_full Outcomes and Complications of Pelvic Chondrosarcomas Treated Using Navigation Guidance and Multidisciplinary Approach: Is the Tumor Volume a Prognostic Factor?
title_fullStr Outcomes and Complications of Pelvic Chondrosarcomas Treated Using Navigation Guidance and Multidisciplinary Approach: Is the Tumor Volume a Prognostic Factor?
title_full_unstemmed Outcomes and Complications of Pelvic Chondrosarcomas Treated Using Navigation Guidance and Multidisciplinary Approach: Is the Tumor Volume a Prognostic Factor?
title_short Outcomes and Complications of Pelvic Chondrosarcomas Treated Using Navigation Guidance and Multidisciplinary Approach: Is the Tumor Volume a Prognostic Factor?
title_sort outcomes and complications of pelvic chondrosarcomas treated using navigation guidance and multidisciplinary approach: is the tumor volume a prognostic factor?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740033/
https://www.ncbi.nlm.nih.gov/pubmed/36498687
http://dx.doi.org/10.3390/jcm11237111
work_keys_str_mv AT crimialberto outcomesandcomplicationsofpelvicchondrosarcomastreatedusingnavigationguidanceandmultidisciplinaryapproachisthetumorvolumeaprognosticfactor
AT binitieodiont outcomesandcomplicationsofpelvicchondrosarcomastreatedusingnavigationguidanceandmultidisciplinaryapproachisthetumorvolumeaprognosticfactor
AT crimifilippo outcomesandcomplicationsofpelvicchondrosarcomastreatedusingnavigationguidanceandmultidisciplinaryapproachisthetumorvolumeaprognosticfactor
AT letsongdouglas outcomesandcomplicationsofpelvicchondrosarcomastreatedusingnavigationguidanceandmultidisciplinaryapproachisthetumorvolumeaprognosticfactor
AT joycedavidm outcomesandcomplicationsofpelvicchondrosarcomastreatedusingnavigationguidanceandmultidisciplinaryapproachisthetumorvolumeaprognosticfactor